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ivermectin

The effect of ivermectin® on fertility, fecundity and mortality of Anopheles arabiensis fed on treated men in Ethiopia

November 11, 2019 - 16:16 -- Open Access
Author(s): 
Wondemeneh Mekuriaw, Meshesha Balkew, Louisa A. Messenger, Delenasaw Yewhalaw, Adugna Woyessa and Fekadu Massebo
Reference: 
Malaria Journal 2019 18:357, 8 November 2019

Insecticide resistance is a growing threat to malaria vector control. Ivermectin, either administered to humans or animals, may represent an alternate strategy to reduce resistant mosquito populations. The aim of this study was to assess the residual or delayed effect of administering a single oral dose of ivermectin to humans on the survival, fecundity and fertility of Anopheles arabiensis in Ethiopia.

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Not Open Access | Characterization of the target of ivermectin, the glutamate-gated chloride channel, from Anopheles gambiae

May 23, 2015 - 11:05 -- NOT Open Access
Author(s): 
Jacob I. Meyers, Meg Gray, Wojtek Kuklinski, Lucas B. Johnson, Christopher D. Snow, William C. Black IV, Kathryn M. Partin and Brian D. Foy
Reference: 
J Exp Biol 218, 1478-1486, May 15, 2015

In summary, we have characterized the first GluCl from a mosquito, A. gambiae, and described its unique activity and expression with respect to it as the target of the insecticide IVM.

Research: Duration of the mosquitocidal effect of ivermectin

October 23, 2012 - 15:43 -- Bart G.J. Knols
Author(s): 
Guido J.H. Bastiaens, Geert-Jan van Gemert, Jo Hooghof, Steve W. Lindsay, Chris Drakeley, Thomas S. Churcher, Jan Peter Verhave, Clemens H.M. Kocken, Robert W. Sauerwein, Teun Bousema
Reference: 
MWJ 2012, 3, 10

Ivermectin (IVM) reduces the lifespan of malaria-transmitting mosquitoes after feeding on humans treated with IVM but limited data are available on the exact duration of the mosquitocidal effect of IVM. Daily mosquito feeding assays were conducted to determine this. Mosquito mortality was 70-100% when mosquitoes fed on mice, rats, or cynomolgus monkeys 1-2 days after the last IVM administration. The findings reported here, of a pronounced but short-lived mosquitocidal effect, makes the timing of IVM administration crucial to form a useful addition to anti-malarial drugs.

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