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Not Open Access | Characterization of the target of ivermectin, the glutamate-gated chloride channel, from Anopheles gambiae

May 23, 2015 - 11:05 -- NOT Open Access
Jacob I. Meyers, Meg Gray, Wojtek Kuklinski, Lucas B. Johnson, Christopher D. Snow, William C. Black IV, Kathryn M. Partin and Brian D. Foy
J Exp Biol 218, 1478-1486, May 15, 2015

In summary, we have characterized the first GluCl from a mosquito, A. gambiae, and described its unique activity and expression with respect to it as the target of the insecticide IVM.

Research: Duration of the mosquitocidal effect of ivermectin

October 23, 2012 - 15:43 -- Bart G.J. Knols
Guido J.H. Bastiaens, Geert-Jan van Gemert, Jo Hooghof, Steve W. Lindsay, Chris Drakeley, Thomas S. Churcher, Jan Peter Verhave, Clemens H.M. Kocken, Robert W. Sauerwein, Teun Bousema
MWJ 2012, 3, 10

Ivermectin (IVM) reduces the lifespan of malaria-transmitting mosquitoes after feeding on humans treated with IVM but limited data are available on the exact duration of the mosquitocidal effect of IVM. Daily mosquito feeding assays were conducted to determine this. Mosquito mortality was 70-100% when mosquitoes fed on mice, rats, or cynomolgus monkeys 1-2 days after the last IVM administration. The findings reported here, of a pronounced but short-lived mosquitocidal effect, makes the timing of IVM administration crucial to form a useful addition to anti-malarial drugs.

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