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Malaria vector species composition and entomological indices following indoor residual spraying in regions bordering Lake Victoria, Tanzania

October 31, 2020 - 09:55 -- Open Access
Charles Kakilla, Alphaxard Manjurano, Stephen M. Magesa, et al.
Malaria Journal 2020 19:383, 28 October 2020

Vector control through long-lasting insecticidal nets (LLINs) and focal indoor residual spraying (IRS) is a major component of the Tanzania national malaria control strategy. In mainland Tanzania, IRS has been conducted annually around Lake Victoria basin since 2007. Due to pyrethroid resistance in malaria vectors, use of pyrethroids for IRS was phased out and from 2014 to 2017 pirimiphos-methyl (Actellic® 300CS) was sprayed in regions of Kagera, Geita, Mwanza, and Mara. Entomological surveillance was conducted in 10 sprayed and 4 unsprayed sites to determine the impact of IRS on entomological indices related to malaria transmission risk.

How useful are malaria risk maps at the country level? Perceptions of decision-makers in Kenya, Malawi and the Democratic Republic of Congo

October 6, 2020 - 12:47 -- Open Access
Ludovica Ghilardi, George Okello, Jayne Webster, et al.
Malaria Journal 2020 19:353, 2 October 2020

Declining malaria prevalence and pressure on external funding have increased the need for efficiency in malaria control in sub-Saharan Africa (SSA). Modelled Plasmodium falciparum parasite rate (PfPR) maps are increasingly becoming available and provide information on the epidemiological situation of countries. However, how these maps are understood or used for national malaria planning is rarely explored. In this study, the practices and perceptions of national decision-makers on the utility of malaria risk maps, showing prevalence of parasitaemia or incidence of illness, was investigated.

Emergence of behavioural avoidance strategies of malaria vectors in areas of high LLIN coverage in Tanzania

September 12, 2020 - 15:06 -- Open Access
Kreppel KS, Viana M, Main BJ, Johnson PCD, Govella NJ, Lee Y, Maliti D, Meza FC, Lanzaro GC, Ferguson HM
Sci Rep. 2020 Sep 3;10(1):14527

Despite significant reductions in malaria transmission across Africa since 2000, progress is stalling. This has been attributed to the development of insecticide resistance and behavioural adaptations in malaria vectors. Whilst insecticide resistance has been widely investigated, there is poorer understanding of the emergence, dynamics and impact of mosquito behavioural adaptations.

“After those nets are torn, most people use them for other purposes”: an examination of alternative bed net use in western Kenya

July 29, 2020 - 13:38 -- Open Access
Ellen M. Santos, Jenna E. Coalson, Stephen Munga, Maurice Agawo, Elizabeth T. Jacobs, Yann C. Klimentidis, Mary H. Hayden and Kacey C. Ernst
Malaria Journal 2020 19:272, 29 July 2020

Alternative long-lasting insecticidal net (LLIN) use for purposes other than sleeping protection from mosquitoes is widely debated as a limitation to successful malaria control efforts, yet rarely rigorously studied.

Evidence of high bed net usage from a list randomization experiments in rural Gambia

July 14, 2020 - 09:44 -- Open Access
Joe Brew, Margaret Pinder, Umberto D’Alessandro, Steven W. Lindsay, Caroline Jones and Elisa Sicuri
Malaria Journal 2020 19:248, 13 July 2020

Recording behaviours that have the potential to impact health can be doubly challenging if the behaviour takes place in private spaces that cannot be observed directly, and where respondents answer what they think the recorder may want to hear. Sleeping under a long-lasting insecticidal net (LLIN) is an important intervention for malaria prevention, yet it is difficult to gauge the extent to which coverage (how many nets are in the community) differs from usage (how many people actually sleep under a net). List randomization, a novel method which partially obscures respondents’ answers to sensitive questions, was employed to estimate LLIN usage in The Gambia.

Behavioural plasticity of Anopheles coluzzii and Anopheles arabiensis undermines LLIN community protective effect in a Sudanese-savannah village in Burkina Faso

June 3, 2020 - 15:33 -- Open Access
Perugini E, Guelbeogo WM, Calzetta M, Manzi S, Virgillito C, Caputo B, Pichler V, Ranson H, Sagnon N, Della Torre A, Pombi M
Parasit Vectors. 2020 Jun 1; 13(1):277

Despite the overall major impact of long-lasting insecticide treated nets (LLINs) in eliciting individual and collective protection to malaria infections, some sub-Saharan countries, including Burkina Faso, still carry a disproportionately high share of the global malaria burden. This study aims to analyse the possible entomological bases of LLIN limited impact, focusing on a LLIN-protected village in the Plateau Central region of Burkina Faso.

Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

April 20, 2020 - 09:38 -- Open Access
Staedke SG, Gonahasa S, Donnelly MJ, et al.
Lancet. 2020 Apr 18;395(10232):1292-1303

Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda’s national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors.

Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania

April 20, 2020 - 09:04 -- Open Access
Joshua Yukich, Logan Stuck, Hannah Koenker, et al.
Malaria Journal 2020 19:158, 17 April 2020

Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation of the Tanzania National Voucher Scheme in 2004 and mass-distribution campaigns in 2009–2011 and 2015–2016, Tanzania has been committed to finding new and innovative ways of achieving and maintaining universal bed net coverage.

Use of alternative bioassays to explore the impact of pyrethroid resistance on LLIN efficacy

April 10, 2020 - 17:18 -- Open Access
Grossman MK, Oliver SV, Brooke BD, Thomas MB
Parasit Vectors. 2020 Apr 7;13(1):179

There is substantial concern that the spread of insecticide resistance will render long-lasting insecticide-treated nets (LLINs) ineffective. However, there is limited evidence supporting a clear association between insecticide resistance and malaria incidence or prevalence in the field. We suggest that one reason for this disconnect is that the standard WHO assays used in surveillance to classify mosquito populations as resistant are not designed to determine how resistance might impact LLIN efficacy. The standard assays expose young, unfed female mosquitoes to a diagnostic insecticide dose in a single, forced exposure, whereas in the field, mosquitoes vary in their age, blood-feeding status, and the frequency or intensity of LLIN exposure. These more realistic conditions could ultimately impact the capacity of “resistant” mosquitoes to transmit malaria.

Biological larviciding against malaria vector mosquitoes with Bacillus thuringiensis israelensis (Bti) - Long term observations and assessment of repeatability during an additional intervention year of a large-scale field trial in rural Burkina Faso

January 1, 2020 - 15:56 -- Open Access
Dambach P, Winkler V, Bärnighausen T, Traoré I, Ouedraogo S, Sié A, Sauerborn R, Becker N, Louis VR
Glob Health Action. 2020 Dec 31;13(1):1829828

The first line of malaria vector control to date mainly relies on the use of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS). For integrated vector management, targeting the vector larvae with biological larvicides such as Bacillus thuringiensis israelensis (Bti) can be an effective additional mainstay. This study presents data from the second intervention year of a large-scale trial on biological larviciding with Bti that was carried out in 127 rural villages and a semi-urban town in Burkina Faso.


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