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Behavioural plasticity of Anopheles coluzzii and Anopheles arabiensis undermines LLIN community protective effect in a Sudanese-savannah village in Burkina Faso

June 3, 2020 - 15:33 -- Open Access
Perugini E, Guelbeogo WM, Calzetta M, Manzi S, Virgillito C, Caputo B, Pichler V, Ranson H, Sagnon N, Della Torre A, Pombi M
Parasit Vectors. 2020 Jun 1; 13(1):277

Despite the overall major impact of long-lasting insecticide treated nets (LLINs) in eliciting individual and collective protection to malaria infections, some sub-Saharan countries, including Burkina Faso, still carry a disproportionately high share of the global malaria burden. This study aims to analyse the possible entomological bases of LLIN limited impact, focusing on a LLIN-protected village in the Plateau Central region of Burkina Faso.

Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign

April 20, 2020 - 09:38 -- Open Access
Staedke SG, Gonahasa S, Donnelly MJ, et al.
Lancet. 2020 Apr 18;395(10232):1292-1303

Long-lasting insecticidal nets (LLINs) are the primary malaria prevention tool, but their effectiveness is threatened by pyrethroid resistance. We embedded a pragmatic cluster-randomised trial into Uganda’s national LLIN campaign to compare conventional LLINs with those containing piperonyl butoxide (PBO), a synergist that can partially restore pyrethroid susceptibility in mosquito vectors.

Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania

April 20, 2020 - 09:04 -- Open Access
Joshua Yukich, Logan Stuck, Hannah Koenker, et al.
Malaria Journal 2020 19:158, 17 April 2020

Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation of the Tanzania National Voucher Scheme in 2004 and mass-distribution campaigns in 2009–2011 and 2015–2016, Tanzania has been committed to finding new and innovative ways of achieving and maintaining universal bed net coverage.

Use of alternative bioassays to explore the impact of pyrethroid resistance on LLIN efficacy

April 10, 2020 - 17:18 -- Open Access
Grossman MK, Oliver SV, Brooke BD, Thomas MB
Parasit Vectors. 2020 Apr 7;13(1):179

There is substantial concern that the spread of insecticide resistance will render long-lasting insecticide-treated nets (LLINs) ineffective. However, there is limited evidence supporting a clear association between insecticide resistance and malaria incidence or prevalence in the field. We suggest that one reason for this disconnect is that the standard WHO assays used in surveillance to classify mosquito populations as resistant are not designed to determine how resistance might impact LLIN efficacy. The standard assays expose young, unfed female mosquitoes to a diagnostic insecticide dose in a single, forced exposure, whereas in the field, mosquitoes vary in their age, blood-feeding status, and the frequency or intensity of LLIN exposure. These more realistic conditions could ultimately impact the capacity of “resistant” mosquitoes to transmit malaria.

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