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cerebral malaria

Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria

August 12, 2013 - 07:45 -- Open Access
Author(s): 
Punsawad C, Maneerat Y, Chaisri U, Nantavisai K, Viriyavejakul P
Reference: 
Malaria Journal 2013, 12:260 (26 July 2013)
MalariaWorld

This study documented that NF-?B p65 is one of the signaling factors that modulates apoptosis in the brain ECs and intravascular leukocytes of fatal CM.

Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria

July 17, 2013 - 13:03 -- Open Access
Author(s): 
Joanne Berghout, David Langlais, Irena Radovanovic, Mifong Tam, John D. MacMicking, Mary M. Stevenson, Philippe Gros
Reference: 
PLoS Pathog 9(7): e1003491
MalariaWorld

Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells.

Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria

June 26, 2013 - 09:28 -- Open Access
Author(s): 
Peng Kai Ong, Benoît Melchior, Yuri C. Martins, Anthony Hofer, Pamela Orjuela-Sánchez, Pedro Cabrales, Graziela M. Zanini, John A. Frangos, Leonardo J. M. Carvalho
Reference: 
PLoS Pathog 9(6): e1003444
MalariaWorld

Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage results in impaired perfusion and reduced cerebral blood flow and oxygenation, and has been linked to low nitric oxide (NO) bioavailability.

NOT Open Access | Efficacy of Proveblue (Methylene Blue) in an Experimental Cerebral Malaria Murine Model

June 15, 2013 - 12:06 -- NOT Open Access
Author(s): 
Jérome Dormoi, Sébastien Briolant, Camille Desgrouas, and Bruno Pradines
Reference: 
Antimicrob. Agents Chemother. July 2013 vol. 57 no. 7 3412-3414
MalariaWorld

Although 100% of untreated mice infected with Plasmodium berghei died with specific signs of cerebral malaria and 100% of mice treated with 3 mg/kg dihydroartemisinin

The Impact of Genetic Susceptibility to Systemic Lupus Erythematosus on Placental Malaria in Mice

May 22, 2013 - 06:59 -- Open Access
Author(s): 
Michael Waisberg, Christina K. Lin, Chiung-Yu Huang, Mirna Pena, Marlene Orandle, Silvia Bolland, Susan K. Pierce
Reference: 
PLoS ONE 8(5): e62820
MalariaWorld

Severe malaria, including cerebral malaria (CM) and placental malaria (PM), have been recognized to have many of the features of uncontrolled inflammation.

NOT Open Access | Association of TNF level with production of circulating cellular microparticles during clinical manifestation of human cerebral malaria

May 7, 2013 - 13:22 -- NOT Open Access
Author(s): 
Upasana Sahu, Prakash K. Sahoo, Shantanu K. Kar, Biranchi N. Mohapatra, Manoranjan Ranjit
Reference: 
Human Immunology, Volume 74, Issue 6, June 2013, Pages 713–721
MalariaWorld

Microparticles (MPs) resulting from vesiculation of different cell types in Plasmodium falciparum infection correlate with the level of proinflammatory cytokine TNF that may thereby determine the disease severity.

Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria

April 25, 2013 - 08:08 -- Open Access
Author(s): 
Martins YC, Clemmer L, Orjuela-Sánchez P, Zanini GM, Ong PK, Frangos JA, Carvalho LJ
Reference: 
Malaria Journal 2013, 12:138 (24 April 2013)
MalariaWorld

These data show that slow and continuous delivery of lower doses of nimodipine improves survival of mice with ECM in rescue therapy with artesunate while showing a safer profile in terms of cardiovascular effects.

NOT Open Access | The specific, reversible JNK inhibitor SP600125 improves survivability and attenuates neuronal cell death in experimental cerebral malaria (ECM)

April 18, 2013 - 07:40 -- NOT Open Access
Author(s): 
Sripada Santosh Anand, Mulaka Maruthi & Phanithi Prakash Babu
Reference: 
Parasitology Research, May 2013, Volume 112, Issue 5, pp 1959-1966
MalariaWorld

Cerebral malaria (CM) is the most severe complication of Plasmodium falciparum in humans and major cause of death.

NOT Open Access | Platelet Induction of the Acute-Phase Response Is Protective in Murine Experimental Cerebral Malaria

April 2, 2013 - 14:03 -- NOT Open Access
Author(s): 
Angela A. Aggrey, Kalyan Srivastava, Sara Ture, David J. Field, and Craig N. Morrell
Reference: 
The Journal of Immunology March 27, 2013
MalariaWorld

Our data now suggest that platelets have a complex role in ECM pathogenesis: platelets help limit parasite growth early postinfection, but with continued platelet activation as the disease progresses, platelets contribute to ECM-associated inflammation.

NOT Open Access | Protective role of brain water channel AQP4 in murine cerebral malaria

January 17, 2013 - 12:54 -- NOT Open Access
Author(s): 
Dominique Promeneur, Lisa Kristina Lunde, Mahmood Amiry-Moghaddam, and Peter Agre
Reference: 
PNAS January 15, 2013 vol. 110 no. 3 1035-1040
MalariaWorld

Tragically common among children in sub-Saharan Africa, cerebral malaria is characterized by rapid progression to coma and death.

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