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cerebral malaria

Production, Fate and Pathogenicity of Plasma Microparticles in Murine Cerebral Malaria

March 27, 2014 - 12:13 -- Open Access
Author(s): 
Fatima El-Assaad, Julie Wheway, Nicholas H. Hunt, Georges E. R. Grau, Valery Combe
Reference: 
PLoS Pathog 10(3): e1003839

In patients with cerebral malaria (CM), higher levels of cell-specific microparticles (MP) correlate with the presence of neurological symptoms.

Do you see patients with cerebral malaria? ...Or know someone who does?

March 21, 2014 - 11:16 -- Lakshmi Swamy

If you care for patients with cerebral malaria or know someone who does, then we would appreciate your help in distributing this short survey.
Please use the following link to complete the survey: Cerebral Malaria Diagnosis Survey

I am an ophthalmologist with a background in malaria biology, and I am leading a survey study to understand how clinicians diagnose cerebral malaria.

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

March 12, 2014 - 12:58 -- Open Access
Author(s): 
Lena Serghides, Chloe R. McDonald, Ziyue Lu, Miriam Friedel, Cheryl Cui, Keith T. Ho, Howard T. J. Mount, John G. Sled, Kevin C. Kain
Reference: 
PLoS Pathog 10(3): e1003980

Cerebral malaria (CM) is associated with a high mortality rate, and long-term neurocognitive impairment in approximately one third of survivors.

Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: modelling sustainability of health benefits from mosquito nets, depending on case management

November 13, 2013 - 14:12 -- Open Access
Author(s): 
Briët OJ, Penny MA
Reference: 
Malaria Journal 2013, 12 :401 (7 November 2013)
MalariaWorld

This study reaffirms the importance of context specific intervention planning.

Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria

November 7, 2013 - 10:27 -- Open Access
Author(s): 
Miranda AS, Brant F, Rocha NP, Cisalpino D, Rodrigues DH, Souza DG, Machado FS, Rachid MA, Teixeira Jr AL, Campos AC
Reference: 
Malaria Journal 2013, 12 :388 (2 November 2013)
MalariaWorld

In summary, the current study provided further evidence that CM affects key brain areas related to cognition process.

Plasma and Cerebrospinal Proteomes From Children With Cerebral Malaria Differ From Those of Children With Other Encephalopathies

October 3, 2013 - 18:00 -- Open Access
Author(s): 
Evelyn N. Gitau, Gilbert O. Kokwaro, Henry Karanja, Charles R. J. C. Newton and Stephen A. Ward
Reference: 
J Infect Dis. (2013) 208 (9): 1494-1503.
MalariaWorld

In particular, we report the expression of 2 spectrin proteins that have known Plasmodium falciparum–binding partners involved in the stability of the infected red blood cell, suppressing further invasion and possibly enhancing the red blood cell's ability to sequester in microvasculature.

Person: 

Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model

September 4, 2013 - 11:29 -- Open Access
Author(s): 
Dormoi J, Briolant S, Pascual A, Desgrouas C, Travaillé C, Pradines B
Reference: 
Malaria Journal 2013, 12:302 (30 August 2013)
MalariaWorld

The combination of DHA and AVA seems to be effective as a therapeutic scheme for improving mouse survival but less effective for cytokine modulation, which is associated with protection against CM.

Azadirachta indica ethanolic extract protects neurons from apoptosis and mitigates brain swelling in experimental cerebral malaria

September 4, 2013 - 11:24 -- Open Access
Author(s): 
Bedri S, Khalil EA, Khalid SA, Alzohairy MA, Mohieldein A, Aldebasi YH, Seke Etet PF, Farahna M
Reference: 
Malaria Journal 2013, 12:298 (29 August 2013)
MalariaWorld

The present findings suggest that Azadirachta indica ethanolic extract has protective effects on neuronal populations in the inflamed central nervous system, and justify at least in part its use in African and Asian folk medicine and practices.

Glucocorticosteroids in Nano-Sterically Stabilized Liposomes Are Efficacious for Elimination of the Acute Symptoms of Experimental Cerebral Malaria

September 4, 2013 - 09:10 -- Open Access
Author(s): 
Judith H. Waknine-Grinberg, Simcha Even-Chen, Jasmine Avichzer, Keren Turjeman, Annael Bentura-Marciano, Richard K. Haynes, Lola Weiss, Nahum Allon, Haim Ovadia, Jacob Golenser, Yechezkel Barenholz
Reference: 
PLoS ONE 8(8): e72722
MalariaWorld

Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in malaria-endemic areas

Medical Treatment: 

NOT Open Access | The C-Type Lectin Receptor DCIR Is Crucial for the Development of Experimental Cerebral Malaria

August 22, 2013 - 10:39 -- NOT Open Access
Author(s): 
Maha Maglinao, Robert Klopfleisch, Peter H. Seeberger, and Bernd Lepenies
Reference: 
The Journal of Immunology September 1, 2013 vol. 191 no. 5 2551-2559
MalariaWorld

Cerebral malaria (CM) is the most severe complication of malaria.

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