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cerebral malaria

NOT Open Access | Association of TNF level with production of circulating cellular microparticles during clinical manifestation of human cerebral malaria

May 7, 2013 - 13:22 -- NOT Open Access
Author(s): 
Upasana Sahu, Prakash K. Sahoo, Shantanu K. Kar, Biranchi N. Mohapatra, Manoranjan Ranjit
Reference: 
Human Immunology, Volume 74, Issue 6, June 2013, Pages 713–721
MalariaWorld

Microparticles (MPs) resulting from vesiculation of different cell types in Plasmodium falciparum infection correlate with the level of proinflammatory cytokine TNF that may thereby determine the disease severity.

Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria

April 25, 2013 - 08:08 -- Open Access
Author(s): 
Martins YC, Clemmer L, Orjuela-Sánchez P, Zanini GM, Ong PK, Frangos JA, Carvalho LJ
Reference: 
Malaria Journal 2013, 12:138 (24 April 2013)
MalariaWorld

These data show that slow and continuous delivery of lower doses of nimodipine improves survival of mice with ECM in rescue therapy with artesunate while showing a safer profile in terms of cardiovascular effects.

NOT Open Access | The specific, reversible JNK inhibitor SP600125 improves survivability and attenuates neuronal cell death in experimental cerebral malaria (ECM)

April 18, 2013 - 07:40 -- NOT Open Access
Author(s): 
Sripada Santosh Anand, Mulaka Maruthi & Phanithi Prakash Babu
Reference: 
Parasitology Research, May 2013, Volume 112, Issue 5, pp 1959-1966
MalariaWorld

Cerebral malaria (CM) is the most severe complication of Plasmodium falciparum in humans and major cause of death.

NOT Open Access | Platelet Induction of the Acute-Phase Response Is Protective in Murine Experimental Cerebral Malaria

April 2, 2013 - 14:03 -- NOT Open Access
Author(s): 
Angela A. Aggrey, Kalyan Srivastava, Sara Ture, David J. Field, and Craig N. Morrell
Reference: 
The Journal of Immunology March 27, 2013
MalariaWorld

Our data now suggest that platelets have a complex role in ECM pathogenesis: platelets help limit parasite growth early postinfection, but with continued platelet activation as the disease progresses, platelets contribute to ECM-associated inflammation.

NOT Open Access | Protective role of brain water channel AQP4 in murine cerebral malaria

January 17, 2013 - 12:54 -- NOT Open Access
Author(s): 
Dominique Promeneur, Lisa Kristina Lunde, Mahmood Amiry-Moghaddam, and Peter Agre
Reference: 
PNAS January 15, 2013 vol. 110 no. 3 1035-1040
MalariaWorld

Tragically common among children in sub-Saharan Africa, cerebral malaria is characterized by rapid progression to coma and death.

Severe Childhood Malaria Syndromes Defined by Plasma Proteome Profiles

December 17, 2012 - 14:02 -- Open Access
Author(s): 
Florence Burté, Biobele J. Brown, Delmiro Fernandez-Reyes, et al.
Reference: 
PLoS ONE 7(12): e49778
MalariaWorld

We report that an accurate definition of the major childhood malaria syndromes can be achieved using plasma proteome-patterns.

Not Open Access | Brain mitochondrial function in a murine model of cerebral malaria and the therapeutic effects of rhEPO

December 13, 2012 - 15:02 -- NOT Open Access
Author(s): 
Michael Karlsson, Casper Hempel, Fredrik Sjövall, Magnus J. Hansson, Jørgen A.L. Kurtzhals, Eskil Elmér
Reference: 
The International Journal of Biochemistry & Cell Biology, Volume 45, Issue 1, January 2013, Pages 151-155
MalariaWorld

The animals were divided into four groups; infected injected with saline or with rhEPO, non-infected injected with saline or with rhEPO. Infected mice developed CM and treatment with rhEPO attenuated clinical signs of disease.

Psychology Unveils Pathways To Better Cerebral Malaria Therapy

August 22, 2012 - 08:33 -- Bart G.J. Knols

The article below was contributed by journalist Ntaryike Divine Jr. (Douala, Cameroon) as part of the SjCOOP project in collaboration with MalariaWorld.

Over the years malaria has remained unwavering in its ravages, killing hundreds of thousands worldwide yearly, defying drugs and sapping household coffers of hard-earned income.
 
The disease, prevalent in the tropics is transmitted via bites of female bloodsucking anopheles mosquitoes infected with parasites of the genus Plasmodium.  Of the five plasmodium species, research has proven that P. falciparum is particularly dangerous.

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