Microparticles (MPs) resulting from vesiculation of different cell types in Plasmodium falciparum infection correlate with the level of proinflammatory cytokine TNF that may thereby determine the disease severity.
These data show that slow and continuous delivery of lower doses of nimodipine improves survival of mice with ECM in rescue therapy with artesunate while showing a safer profile in terms of cardiovascular effects.
Cerebral malaria (CM) is the most severe complication of Plasmodium falciparum in humans and major cause of death.
Our data now suggest that platelets have a complex role in ECM pathogenesis: platelets help limit parasite growth early postinfection, but with continued platelet activation as the disease progresses, platelets contribute to ECM-associated inflammation.
Tragically common among children in sub-Saharan Africa, cerebral malaria is characterized by rapid progression to coma and death.
We report that an accurate definition of the major childhood malaria syndromes can be achieved using plasma proteome-patterns.
The animals were divided into four groups; infected injected with saline or with rhEPO, non-infected injected with saline or with rhEPO. Infected mice developed CM and treatment with rhEPO attenuated clinical signs of disease.
The article below was contributed by journalist Ntaryike Divine Jr. (Douala, Cameroon) as part of the SjCOOP project in collaboration with MalariaWorld.