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cerebral malaria

Not Open Access | Cerebral malaria: susceptibility weighted MRI

January 28, 2015 - 14:48 -- NOT Open Access
Vinit Baliyan, Jeyaseelan Nadarajah, Atin Kumar, Zohra Ahmad
Asian Pacific Journal of Tropical Disease, Volume 5, Issue 3, March 2015, Pages 239-241

Histopathological studies in cerebral malaria have revealed microbleeds in brain parenchyma secondary to microangiopathy. Susceptibility weighted imaging, being exquisitely sensitive to microbleeds may provide additional information and improve the diagnostic accuracy of MRI in cerebral malaria.

Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier

December 29, 2014 - 13:24 -- Open Access
Adéla Nacer, Alexandru Movila, Fabien Sohet, Natasha M. Girgis, Uma Mahesh Gundra, P'ng Loke, Richard Daneman, Ute Frevert
PLoS Pathog 10(12): e1004528

Cerebral malaria claims the lives of over 600,000 African children every year.

Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria

September 4, 2014 - 11:52 -- Open Access
Almelli T, Ndam NT, Ezimegnon S, Alao MJ, Ahouansou C, Sagbo G, Amoussou A, Deloron P, Tahar R
Malaria Journal 2014, 13 :333 (25 August 2014)

CM isolates bind significantly more to CD36 than to ICAM-1, which was correlated with high transcription level of group B var genes, supporting their implication in malaria pathogenesis.

Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-Like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model

August 19, 2014 - 14:07 -- Open Access
Johan Normark, Maria Nelson, Patrik Engström, Marie Andersson, Rafael Björk, Thomas Moritz, Anna Fahlgren, Sven Bergström
PLoS ONE 9(7): e103295

In the Plasmodium infected host, a balance between pro- and anti-inflammatory responses is required to clear the parasites without inducing major host pathology.

Not Open Access | Targeting the olfactory bulb during experimental cerebral malaria

July 31, 2014 - 16:02 -- NOT Open Access
Laurent Rénia, Shanshan Wu Howland
Trends in Parasitology, Volume 30, Issue 8, August 2014, Pages 375-376

In a new study, Coban and colleagues provide new clues on the involvement of the olfactory bulb during experimental cerebral malaria in mice that open the way to testable hypotheses and potentially earlier intervention in humans.

NOT Open Access | Vitamin D Inhibits the Occurrence of Experimental Cerebral Malaria in Mice by Suppressing the Host Inflammatory Response

July 22, 2014 - 09:34 -- NOT Open Access
Xiyue He, Juan Yan, Xiaotong Zhu, Qinghui Wang, Wei Pang, Zanmei Qi, Meilian Wang, Enjie Luo, Daniel M. Parker, Margherita T. Cantorna, Liwang Cui, and Yaming Cao
The Journal of Immunology August 1, 2014 vol. 193 no. 3 1314-1323

In animal models of experimental cerebral malaria (ECM), neuropathology is associated with an overwhelming inflammatory response and sequestration of leukocytes and parasite-infected RBCs in the brain.

Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis

July 21, 2014 - 16:37 -- Open Access
Saparna Pai, Jim Qin, Lois Cavanagh, Andrew Mitchell, Fatima El-Assaad, Rohit Jain, Valery Combes, Nicholas H. Hunt, Georges E. R. Grau, Wolfgang Weninger
PLoS Pathog 10(7): e1004236

During experimental cerebral malaria (ECM) mice develop a lethal neuropathological syndrome associated with microcirculatory dysfunction and intravascular leukocyte sequestration.

Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria

May 1, 2014 - 07:48 -- Open Access
Julie Bachmann, Florence Burté, Peter Nilsson, et al.
PLoS Pathog 10(4): e1004038

Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria.

Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei

April 11, 2014 - 18:54 -- Open Access
Wang M, Feng Y, Pang W, Qi Z, Zhang Y, Guo Y, Luo E, Cao Y
Malaria Journal 2014, 13 :116 (26 March 2014)

This study demonstrates that protection for ECM depends on the numbers of the parasites, S. japonicum and P. berghei, during co-infection. Alterations in the regulatory response appear to play a key role in this adaptation.


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