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cerebral malaria

Plasma and Cerebrospinal Proteomes From Children With Cerebral Malaria Differ From Those of Children With Other Encephalopathies

October 3, 2013 - 18:00 -- Open Access
Author(s): 
Evelyn N. Gitau, Gilbert O. Kokwaro, Henry Karanja, Charles R. J. C. Newton and Stephen A. Ward
Reference: 
J Infect Dis. (2013) 208 (9): 1494-1503.
MalariaWorld

In particular, we report the expression of 2 spectrin proteins that have known Plasmodium falciparum–binding partners involved in the stability of the infected red blood cell, suppressing further invasion and possibly enhancing the red blood cell's ability to sequester in microvasculature.

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Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model

September 4, 2013 - 11:29 -- Open Access
Author(s): 
Dormoi J, Briolant S, Pascual A, Desgrouas C, Travaillé C, Pradines B
Reference: 
Malaria Journal 2013, 12:302 (30 August 2013)
MalariaWorld

The combination of DHA and AVA seems to be effective as a therapeutic scheme for improving mouse survival but less effective for cytokine modulation, which is associated with protection against CM.

Azadirachta indica ethanolic extract protects neurons from apoptosis and mitigates brain swelling in experimental cerebral malaria

September 4, 2013 - 11:24 -- Open Access
Author(s): 
Bedri S, Khalil EA, Khalid SA, Alzohairy MA, Mohieldein A, Aldebasi YH, Seke Etet PF, Farahna M
Reference: 
Malaria Journal 2013, 12:298 (29 August 2013)
MalariaWorld

The present findings suggest that Azadirachta indica ethanolic extract has protective effects on neuronal populations in the inflamed central nervous system, and justify at least in part its use in African and Asian folk medicine and practices.

Glucocorticosteroids in Nano-Sterically Stabilized Liposomes Are Efficacious for Elimination of the Acute Symptoms of Experimental Cerebral Malaria

September 4, 2013 - 09:10 -- Open Access
Author(s): 
Judith H. Waknine-Grinberg, Simcha Even-Chen, Jasmine Avichzer, Keren Turjeman, Annael Bentura-Marciano, Richard K. Haynes, Lola Weiss, Nahum Allon, Haim Ovadia, Jacob Golenser, Yechezkel Barenholz
Reference: 
PLoS ONE 8(8): e72722
MalariaWorld

Cerebral malaria is the most severe complication of Plasmodium falciparum infection, and a leading cause of death in children under the age of five in malaria-endemic areas

Medical Treatment: 

NOT Open Access | The C-Type Lectin Receptor DCIR Is Crucial for the Development of Experimental Cerebral Malaria

August 22, 2013 - 10:39 -- NOT Open Access
Author(s): 
Maha Maglinao, Robert Klopfleisch, Peter H. Seeberger, and Bernd Lepenies
Reference: 
The Journal of Immunology September 1, 2013 vol. 191 no. 5 2551-2559
MalariaWorld

Cerebral malaria (CM) is the most severe complication of malaria.

Nuclear factor kappa B modulates apoptosis in the brain endothelial cells and intravascular leukocytes of fatal cerebral malaria

August 12, 2013 - 07:45 -- Open Access
Author(s): 
Punsawad C, Maneerat Y, Chaisri U, Nantavisai K, Viriyavejakul P
Reference: 
Malaria Journal 2013, 12:260 (26 July 2013)
MalariaWorld

This study documented that NF-?B p65 is one of the signaling factors that modulates apoptosis in the brain ECs and intravascular leukocytes of fatal CM.

Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria

July 17, 2013 - 13:03 -- Open Access
Author(s): 
Joanne Berghout, David Langlais, Irena Radovanovic, Mifong Tam, John D. MacMicking, Mary M. Stevenson, Philippe Gros
Reference: 
PLoS Pathog 9(7): e1003491
MalariaWorld

Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells.

Nitric Oxide Synthase Dysfunction Contributes to Impaired Cerebroarteriolar Reactivity in Experimental Cerebral Malaria

June 26, 2013 - 09:28 -- Open Access
Author(s): 
Peng Kai Ong, Benoît Melchior, Yuri C. Martins, Anthony Hofer, Pamela Orjuela-Sánchez, Pedro Cabrales, Graziela M. Zanini, John A. Frangos, Leonardo J. M. Carvalho
Reference: 
PLoS Pathog 9(6): e1003444
MalariaWorld

Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage results in impaired perfusion and reduced cerebral blood flow and oxygenation, and has been linked to low nitric oxide (NO) bioavailability.

NOT Open Access | Efficacy of Proveblue (Methylene Blue) in an Experimental Cerebral Malaria Murine Model

June 15, 2013 - 12:06 -- NOT Open Access
Author(s): 
Jérome Dormoi, Sébastien Briolant, Camille Desgrouas, and Bruno Pradines
Reference: 
Antimicrob. Agents Chemother. July 2013 vol. 57 no. 7 3412-3414
MalariaWorld

Although 100% of untreated mice infected with Plasmodium berghei died with specific signs of cerebral malaria and 100% of mice treated with 3 mg/kg dihydroartemisinin

The Impact of Genetic Susceptibility to Systemic Lupus Erythematosus on Placental Malaria in Mice

May 22, 2013 - 06:59 -- Open Access
Author(s): 
Michael Waisberg, Christina K. Lin, Chiung-Yu Huang, Mirna Pena, Marlene Orandle, Silvia Bolland, Susan K. Pierce
Reference: 
PLoS ONE 8(5): e62820
MalariaWorld

Severe malaria, including cerebral malaria (CM) and placental malaria (PM), have been recognized to have many of the features of uncontrolled inflammation.

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