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cerebral malaria

NOT Open Access | Vitamin D Inhibits the Occurrence of Experimental Cerebral Malaria in Mice by Suppressing the Host Inflammatory Response

July 22, 2014 - 09:34 -- NOT Open Access
Xiyue He, Juan Yan, Xiaotong Zhu, Qinghui Wang, Wei Pang, Zanmei Qi, Meilian Wang, Enjie Luo, Daniel M. Parker, Margherita T. Cantorna, Liwang Cui, and Yaming Cao
The Journal of Immunology August 1, 2014 vol. 193 no. 3 1314-1323

In animal models of experimental cerebral malaria (ECM), neuropathology is associated with an overwhelming inflammatory response and sequestration of leukocytes and parasite-infected RBCs in the brain.

Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis

July 21, 2014 - 16:37 -- Open Access
Saparna Pai, Jim Qin, Lois Cavanagh, Andrew Mitchell, Fatima El-Assaad, Rohit Jain, Valery Combes, Nicholas H. Hunt, Georges E. R. Grau, Wolfgang Weninger
PLoS Pathog 10(7): e1004236

During experimental cerebral malaria (ECM) mice develop a lethal neuropathological syndrome associated with microcirculatory dysfunction and intravascular leukocyte sequestration.

Affinity Proteomics Reveals Elevated Muscle Proteins in Plasma of Children with Cerebral Malaria

May 1, 2014 - 07:48 -- Open Access
Julie Bachmann, Florence Burté, Peter Nilsson, et al.
PLoS Pathog 10(4): e1004038

Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria.

Parasite densities modulate susceptibility of mice to cerebral malaria during co-infection with Schistosoma japonicum and Plasmodium berghei

April 11, 2014 - 18:54 -- Open Access
Wang M, Feng Y, Pang W, Qi Z, Zhang Y, Guo Y, Luo E, Cao Y
Malaria Journal 2014, 13 :116 (26 March 2014)

This study demonstrates that protection for ECM depends on the numbers of the parasites, S. japonicum and P. berghei, during co-infection. Alterations in the regulatory response appear to play a key role in this adaptation.

Production, Fate and Pathogenicity of Plasma Microparticles in Murine Cerebral Malaria

March 27, 2014 - 12:13 -- Open Access
Fatima El-Assaad, Julie Wheway, Nicholas H. Hunt, Georges E. R. Grau, Valery Combe
PLoS Pathog 10(3): e1003839

In patients with cerebral malaria (CM), higher levels of cell-specific microparticles (MP) correlate with the presence of neurological symptoms.

Do you see patients with cerebral malaria? ...Or know someone who does?

March 21, 2014 - 11:16 -- Lakshmi Swamy

If you care for patients with cerebral malaria or know someone who does, then we would appreciate your help in distributing this short survey.
Please use the following link to complete the survey: Cerebral Malaria Diagnosis Survey

I am an ophthalmologist with a background in malaria biology, and I am leading a survey study to understand how clinicians diagnose cerebral malaria.

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

March 12, 2014 - 12:58 -- Open Access
Lena Serghides, Chloe R. McDonald, Ziyue Lu, Miriam Friedel, Cheryl Cui, Keith T. Ho, Howard T. J. Mount, John G. Sled, Kevin C. Kain
PLoS Pathog 10(3): e1003980

Cerebral malaria (CM) is associated with a high mortality rate, and long-term neurocognitive impairment in approximately one third of survivors.

Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: modelling sustainability of health benefits from mosquito nets, depending on case management

November 13, 2013 - 14:12 -- Open Access
Briët OJ, Penny MA
Malaria Journal 2013, 12 :401 (7 November 2013)

This study reaffirms the importance of context specific intervention planning.

Further evidence for an anti-inflammatory role of artesunate in experimental cerebral malaria

November 7, 2013 - 10:27 -- Open Access
Miranda AS, Brant F, Rocha NP, Cisalpino D, Rodrigues DH, Souza DG, Machado FS, Rachid MA, Teixeira Jr AL, Campos AC
Malaria Journal 2013, 12 :388 (2 November 2013)

In summary, the current study provided further evidence that CM affects key brain areas related to cognition process.


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