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cerebral malaria

NOT Open Access | Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis

February 1, 2018 - 16:15 -- NOT Open Access
J. Palomo, V. F. J. Quesniaux, D. Togbe, F. Reverchon and B. Ryffel
Parasite Immunology, Volume 40, Issue 2, February 2018

Cerebral malaria (CM) is one complication of Plasmodium parasite infection that can lead to strong inflammatory immune responses in the central nervous system (CNS), accompanied by lung inflammation and anaemia.

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65

January 10, 2018 - 15:38 -- Open Access
Diletta Scaccabarozzi, Katrien Deroost, Yolanda Corbett, Natacha Lays, Paola Corsetto, Fausta Omodeo Salè, Philippe E. Van den Steen and Donatella Taramelli
Malaria Journal 2018 17:18, 9 January 2018

This study demonstrates that in C57BL/6J mice, depending on the parasite species, malaria-induced liver pathology results in different manifestations, which may contribute to the different outcomes.

Medical Condition: 

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

November 15, 2017 - 16:08 -- Open Access
Valerie M. Crowley, Kodjo Ayi, Ziyue Lu, Karen T. Liby, Michael Sporn and Kevin C. Kain
Malaria Journal 2017 16:463, 14 November 2017

These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.

Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria

November 15, 2017 - 16:02 -- Open Access
Anne Kessler, Selasi Dankwa, Kami Kim, et al.
Cell Host & Microbe Volume 22, Issue 5, 8 November 2017, Pages 601-614.e5

Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM).

A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration

November 14, 2017 - 15:53 -- Open Access
Pedro Mejia, J. Humberto Treviño-Villarreal, Justin S. Reynolds, Mariana De Niz, Andrew Thompson, Matthias Marti and James R. Mitchell
Malaria Journal 2017 16:455, 9 November 2017

Rapamycin exerts pleotropic effects on host immunity, vascular activation and parasite sequestration that rescue mice from ECM, and thus support the potential clinical use of rapamycin as an adjunctive therapy in CM.

Cerebral malaria induces electrophysiological and neurochemical impairment in mice retinal tissue: possible effect on glutathione and glutamatergic system

November 2, 2017 - 15:52 -- Open Access
Karen R. H. M. Oliveira, Nayara Kauffmann, Luana K. R. Leão, Adelaide C. F. Passos, Fernando A. F. Rocha, Anderson M. Herculano and José L. M. do Nascimento
Malaria Journal 2017 16:440, 2 November 2017

In summary, these findings indicate for the first time that CM induces neurochemical and electrophysiological impairment in the mice retinal tissue, in a TNF-independent manner.

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

August 2, 2017 - 17:01 -- Open Access
Dag Holmberg, Elisabeth Franzén-Röhl, Chandy C. John, et al.
Malaria Journal 2017 16:303, 28 July 2017

CSF KYNA and kynurenine are elevated in children with CM, indicating an inhibition of glutamatergic and cholinergic signaling.

Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model

July 5, 2017 - 14:14 -- Open Access
Onyango C. Odhiambo, Hannah N. Wamakima, Gabriel N. Magoma, Peter G. Kirira, Bonface J. Malala, Francis T. Kimani and Francis W. Muregi
Malaria Journal 2017 16:268, 3 July 2017

Covalent bitherapy proves to be a viable source of urgently needed new anti-malarials for management of cerebral malaria, and this polypharmacology approach could be a potential strategy to protect artesunate from parasite resistance and in potentially improving clinical outcomes in severe forms of malaria infections.

NOT Open Access | Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

June 21, 2017 - 15:38 -- NOT Open Access
E. Shabani, B. J. Ouma, R. Idro, P. Bangirana, R. O. Opoka, G. S. Park, A. L. Conroy and C. C. John
Parasite Immunology, Volume 39, Issue 7, July 2017 e12438

Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration.


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