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cerebral malaria

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

April 2, 2016 - 16:55 -- Open Access
Author(s): 
Brandi D. Freeman, Yuri C. Martins, Oscar B. Akide-Ndunge, Fernando P. Bruno, Hua Wang, Herbert B. Tanowitz, David C. Spray, Mahalia S. Desruisseaux
Reference: 
PLoS Pathog 12(3): e1005477

Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy.

Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort

April 2, 2016 - 16:19 -- Open Access
Author(s): 
Richard Idro, Angelina Kakooza-Mwesige, Joyce Nalugya, et al.
Reference: 
Malaria Journal 2016 15:184, 31 March 2016

Cerebral malaria may predispose children to mental health disorders, possibly as a consequence of ischaemic neural injury.

NOT Open Access | New pentasubstituted pyrrole hybrid atorvastatin–quinoline derivatives with antiplasmodial activity

March 29, 2016 - 17:53 -- NOT Open Access
Author(s): 
Rita C.C. Carvalho, Wagner A. Martins, Tayara P. Silva, Carlos R. Kaiser, Mônica M. Bastos, Luiz C.S. Pinheiro, Antoniana U. Krettli, Núbia Boechat
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 26, Issue 8, 15 April 2016, Pages 1881–1884

Cerebral malaria is caused by Plasmodium falciparum. Atorvastatin (AVA) is a pentasubstituted pyrrole, which has been tested as an adjuvant in the treatment of cerebral malaria.

NOT Open Access | Plasmodium vivax Malaria Presenting with Multifocal Hemorrhagic Brain Infarcts in a School-going Child

March 19, 2016 - 18:42 -- NOT Open Access
Author(s): 
Santosh Kumar Rathia, Jhuma Sankar, Devasenathipathy Kandasamy, and Rakesh Lodha
Reference: 
J Trop Pediatr March 10, 2016

Cerebral malaria is a well-known complication of Plasmodium falciparum malaria.

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

March 9, 2016 - 09:16 -- Open Access
Author(s): 
Catherine Manix Feintuch, Alex Saidi, Johanna P. Daily, et al.
Reference: 
mBio vol. 7 no. 1 e01300-15

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparum-infected red blood cells (iRBCs).

Country: 

A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments

January 20, 2016 - 15:03 -- Open Access
Author(s): 
David J. Sullivan, Jr.
Reference: 
mBio vol. 6 no. 6, 17 November 2015 , e01818-15

Severe malaria is a density-dependent disease that comprises infected-erythrocyte sequestration, with or without monocytic infiltration, as seen in renal, placental, and lung tissues from severe malaria patients.

Lipid metabolites of the phospholipase A 2 pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

December 29, 2015 - 16:07 -- Open Access
Author(s): 
Vasiliki Pappa, Karl Seydel, Johanna Daily, et al.
Reference: 
Malaria Journal 2015, 14:513 (21 December 2015)

Taken together, paediatric CM brain volume was associated with products of the PLA 2 pathway and inflammatory cytokines.

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

November 19, 2015 - 06:32 -- Open Access
Author(s): 
Tovah N. Shaw, Phillip J. Stewart-Hutchinson, Michael L. Dustin, et al.
Reference: 
PLoS Pathog 11(11): e1005210

There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice

Nitrite therapy for cerebral malaria

November 12, 2015 - 08:34 -- Pierre Lutgen

A paper published twenty years ago should have attracted more attention (NM Anstey et al., J Exp Med 1996, 184, 557-567) : the suppression of NO synthesis in cerebral malaria appears to enhance pathogenesis and increased NO synthesis protects against clinical disease. The work was based on in vivo results obtained in Tanzanian children. Already five years earlier the killing of Plasmodium falciparum in vitro by nitric oxide derivatives (NO, nitrite, nitrate) had been demonstrated (KA Rockett et al., Infection and Immunity, 1991, 59, 3280-3283).

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

November 10, 2015 - 05:26 -- Open Access
Author(s): 
Sarah E. Hochman, Theresa F. Madaline, Kami Kim, et al.
Reference: 
mBio.01390-15, 22 September 2015 mBio vol. 6 no. 5 e01390-15

Cerebral malaria (CM) is a major contributor to malaria deaths, but its pathophysiology is not well understood.

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