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cerebral malaria

NOT Open Access | Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

June 21, 2017 - 15:38 -- NOT Open Access
Author(s): 
E. Shabani, B. J. Ouma, R. Idro, P. Bangirana, R. O. Opoka, G. S. Park, A. L. Conroy and C. C. John
Reference: 
Parasite Immunology, Volume 39, Issue 7, July 2017 e12438

Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration.

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria

May 10, 2017 - 15:27 -- Open Access
Author(s): 
Flora Reverchon, Stéphane Mortaud, Valérie F. J. Quesniaux, et al.
Reference: 
PLoS Pathog 13(4): e1006322

Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors.

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

December 22, 2016 - 12:38 -- Open Access
Author(s): 
Phillip A. Swanson II, Geoffrey T. Hart, Dorian B. McGavern, et al.
Reference: 
PLoS Pathog 12(12): e1006022

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children.

Person: 
Continent: 

NOT Open Access | Role of TGF-β and IL-6 in dendritic cells, Treg and Th17 mediated immune response during experimental cerebral malaria

November 2, 2016 - 08:06 -- NOT Open Access
Author(s): 
Tarun Keswani, Samrat Sarkar, Anirban Sengupta, Arindam Bhattacharyya
Reference: 
Cytokine, Volume 88, December 2016, Pages 154–166

The role of cytokines in Plasmodium infection have been extensively investigated, but pro and anti inflammatory cytokines mediated imbalance during malaria immune-pathogenesis is still unrevealed.

NOT Open Access | Cerebral malaria in a man with Plasmodium vivax mono-infection: a case report

October 6, 2016 - 17:25 -- NOT Open Access
Author(s): 
Himanshu Gupta, Pushwinder Dhunputh, Ankita N Bhatt, Kapaettu Satyamoorthy, and Shashikiran Umakanth
Reference: 
Trop Doct October 2016 vol. 46 no. 4 241-245

Cerebral malaria (CM) is a diffuse encephalopathy associated with coma and seizures commonly caused by Plasmodium falciparum (P. falciparum) in children with severe malaria.

Glucagon-like peptide-1 analogue, liraglutide, in experimental cerebral malaria: implications for the role of oxidative stress in cerebral malaria

August 26, 2016 - 17:57 -- Open Access
Author(s): 
Brian DellaValle, Casper Hempel, Trine Staalsoe, Flemming Fryd Johansen and Jørgen Anders Lindholm Kurtzhals
Reference: 
Malaria Journal 2016 15:427, 24 August 2016

Despite the breadth of models where GLP-1 is neuroprotective, ECM was not affected by liraglutide providing important insight into the pathogenesis of ECM.

Plasma levels of eight different mediators and their potential as biomarkers of various clinical malaria conditions in African children

July 2, 2016 - 16:13 -- Open Access
Author(s): 
Rachida Tahar, Catarina Albergaria, Neil Zeghidour, Vincent Foumane Ngane, Leonardo K. Basco and Christian Roussilhon
Reference: 
Malaria Journal 2016 15:337, 29 June 2016

The results indicate that the simultaneous evaluation of these bioactive molecules as quantifiable blood parameters may be helpful to get a better insight into the clinical syndromes in children with malaria.

Psychiatric effects of malaria and anti-malarial drugs: historical and modern perspectives

June 28, 2016 - 16:34 -- Open Access
Author(s): 
Remington L. Nevin and Ashley M. Croft
Reference: 
Malaria Journal 2016 15:332, 22 June 2016

The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment.

Medical Treatment: 

Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria

May 11, 2016 - 16:14 -- Open Access
Author(s): 
Neda Moradin, Sabrina Torre, Susan Gauthier, Mifong Tam, Jalal Hawari, Kirsten Vandercruyssen, Bart De Spiegeleer, Anny Fortin, Mary M. Stevenson and Philippe Gros
Reference: 
Malaria Journal 2016 15:260, 6 May 2016

These findings indicate that inclusion of Cys in current formulations of ACT, or its use as adjunct therapy could improve the anti-plasmodial activity of artemisinin, decrease mortality in cerebral malaria patients, and prevent or delay the development and spread of artemisinin resistance.

Medical Treatment: 

Early prediction of cerebral malaria by 1H NMR based metabolomics

April 12, 2016 - 16:56 -- Open Access
Author(s): 
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma and Haripalsingh M. Sonawat
Reference: 
Malaria Journal 2016 15:198, 12 April 2016

This study clearly demonstrates the possibility of differentiating and identifying animals with CM at an early, pre-clinical stage.

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