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cerebral malaria

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

March 9, 2016 - 09:16 -- Open Access
Catherine Manix Feintuch, Alex Saidi, Johanna P. Daily, et al.
mBio vol. 7 no. 1 e01300-15

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparum-infected red blood cells (iRBCs).


A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments

January 20, 2016 - 15:03 -- Open Access
David J. Sullivan, Jr.
mBio vol. 6 no. 6, 17 November 2015 , e01818-15

Severe malaria is a density-dependent disease that comprises infected-erythrocyte sequestration, with or without monocytic infiltration, as seen in renal, placental, and lung tissues from severe malaria patients.

Lipid metabolites of the phospholipase A 2 pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

December 29, 2015 - 16:07 -- Open Access
Vasiliki Pappa, Karl Seydel, Johanna Daily, et al.
Malaria Journal 2015, 14:513 (21 December 2015)

Taken together, paediatric CM brain volume was associated with products of the PLA 2 pathway and inflammatory cytokines.

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

November 19, 2015 - 06:32 -- Open Access
Tovah N. Shaw, Phillip J. Stewart-Hutchinson, Michael L. Dustin, et al.
PLoS Pathog 11(11): e1005210

There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice

Nitrite therapy for cerebral malaria

November 12, 2015 - 08:34 -- Pierre Lutgen

A paper published twenty years ago should have attracted more attention (NM Anstey et al., J Exp Med 1996, 184, 557-567) : the suppression of NO synthesis in cerebral malaria appears to enhance pathogenesis and increased NO synthesis protects against clinical disease. The work was based on in vivo results obtained in Tanzanian children. Already five years earlier the killing of Plasmodium falciparum in vitro by nitric oxide derivatives (NO, nitrite, nitrate) had been demonstrated (KA Rockett et al., Infection and Immunity, 1991, 59, 3280-3283).

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

November 10, 2015 - 05:26 -- Open Access
Sarah E. Hochman, Theresa F. Madaline, Kami Kim, et al.
mBio.01390-15, 22 September 2015 mBio vol. 6 no. 5 e01390-15

Cerebral malaria (CM) is a major contributor to malaria deaths, but its pathophysiology is not well understood.

NOT Open Access | Investigating proteasome inhibitors as potential adjunct therapies for experimental cerebral malaria

October 28, 2015 - 06:06 -- NOT Open Access
S. W. Howland, G. X. P. Ng, S. K. Chia and L. Rénia
Parasite Immunology, Volume 37, Issue 11, pages 599–604, November 2015

Aside from antimalarials, there is currently no treatment for cerebral malaria, a fulminant neurological complication of P. falciparum infection that is a leading cause of death in African children.

Medical Treatment: 

Not Open Access | Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

October 27, 2015 - 07:25 -- NOT Open Access
Emile B. Gordon, Geoffrey T. Hart, Susan K. Pierce, et al.
PNAS October 20, 2015 vol. 112 no. 42 13075-13080

The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15–25% in African children despite effective antimalarial chemotherapy.


Plant Hormone Salicylic Acid Produced by a Malaria Parasite Controls Host Immunity and Cerebral Malaria Outcome

October 20, 2015 - 08:05 -- Open Access
Ryuma Matsubara, Hiroka Aonuma, Mikiko Kojima, Michiru Tahara, Syed Bilal Ahmad Andrabi, Hitoshi Sakakibara, Kisaburo Nagamune
PLoS ONE 10(10): e0140559

The apicomplexan parasite Toxoplasma gondii produces the plant hormone abscisic acid, but it is unclear if phytohormones are produced by the malaria parasite Plasmodium spp., the most important parasite of this phylum.

The evidence for a role of vasospasm in the pathogenesis of cerebral malaria

October 14, 2015 - 10:58 -- Open Access
Michael Eisenhut
Malaria Journal 2015, 14:405 (13 October 2015)

Due to delay in treatment, cerebral malaria (CM) remains a significant complication of Plasmodium falciparum infection and is a common cause of death from malaria.


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