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cerebral malaria

Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria

August 12, 2015 - 13:25 -- Open Access
Cynthia H Val, Fátima Brant, Fabiana S Machado, et al.
Malaria Journal 2015, 14:311 (11 August 2015)

This study strongly suggests that the administration of A. blazei (aqueous extract or fraction C) was effective in improving the consequences of CM in mice and may provide novel therapeutic strategies.

L-arginine exacerbates experimental cerebral malaria by enhancing pro-inflammatory responses.

May 5, 2015 - 15:23 -- Open Access
Xu H, Feng Y, Chen G, Zhu X, Pang W, Du Y, Wang Q, Qi Z, Cao Y
Tohoku J Exp Med. 2015;236(1):21-31

Here, we tested effects of L-Arg treatment on the outcomes of CM using a mouse model. Experimental cerebral malaria (ECM) was induced in female C57BL/6 mice infected with Plasmodium berghei ANKA, and L-Arg was administrated either prophylactically or after parasite infection.

Not Open Access | Disruption of parasite hmgb2 gene attenuates Plasmodium berghei ANKA pathogenicity

April 28, 2015 - 16:47 -- NOT Open Access
Sylvie Briquet, Nadou Lawson-Hogban, Bertrand Boisson, Miguel P. Soares, Roger Péronet, Leanna Smith, Robert Ménard, Michel Huerre, Salah Mécheri, and Catherine Vaquero
Infect. Immun. 27 April 2015

We found that the Plasmodium genome encodes two genuine HMGB factors, Plasmodium HMGB1 and HMGB2 that encompass, as their human counterparts, a pro-inflammatory domain.

Not Open Access | High Plasma Levels of Soluble Endothelial Protein C Receptor Are Associated With Increased Mortality Among Children With Cerebral Malaria in Benin

April 11, 2015 - 11:53 -- NOT Open Access
Azizath Moussiliou, Maroufou J. Alao, Nicaise Tuikue Ndam, et al.
J Infect Dis. (2015) 211 (9): 1484-1488

In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality.

Iron Prevents the Development of Experimental Cerebral Malaria by Attenuating CXCR3-Mediated T Cell Chemotaxis

March 26, 2015 - 10:22 -- Open Access
Kristin M. Van Den Ham, Marina Tiemi Shio, Anthony Rainone, Sylvie Fournier, Connie M. Krawczyk, Martin Olivier
PLoS ONE 10(3): e0118451

Cerebral malaria is a severe neurological complication of Plasmodium falciparum infection.

Not Open Access | Cerebral malaria: susceptibility weighted MRI

January 28, 2015 - 14:48 -- NOT Open Access
Vinit Baliyan, Jeyaseelan Nadarajah, Atin Kumar, Zohra Ahmad
Asian Pacific Journal of Tropical Disease, Volume 5, Issue 3, March 2015, Pages 239-241

Histopathological studies in cerebral malaria have revealed microbleeds in brain parenchyma secondary to microangiopathy. Susceptibility weighted imaging, being exquisitely sensitive to microbleeds may provide additional information and improve the diagnostic accuracy of MRI in cerebral malaria.

Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier

December 29, 2014 - 13:24 -- Open Access
Adéla Nacer, Alexandru Movila, Fabien Sohet, Natasha M. Girgis, Uma Mahesh Gundra, P'ng Loke, Richard Daneman, Ute Frevert
PLoS Pathog 10(12): e1004528

Cerebral malaria claims the lives of over 600,000 African children every year.

Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria

September 4, 2014 - 11:52 -- Open Access
Almelli T, Ndam NT, Ezimegnon S, Alao MJ, Ahouansou C, Sagbo G, Amoussou A, Deloron P, Tahar R
Malaria Journal 2014, 13 :333 (25 August 2014)

CM isolates bind significantly more to CD36 than to ICAM-1, which was correlated with high transcription level of group B var genes, supporting their implication in malaria pathogenesis.

Maladjusted Host Immune Responses Induce Experimental Cerebral Malaria-Like Pathology in a Murine Borrelia and Plasmodium Co-Infection Model

August 19, 2014 - 14:07 -- Open Access
Johan Normark, Maria Nelson, Patrik Engström, Marie Andersson, Rafael Björk, Thomas Moritz, Anna Fahlgren, Sven Bergström
PLoS ONE 9(7): e103295

In the Plasmodium infected host, a balance between pro- and anti-inflammatory responses is required to clear the parasites without inducing major host pathology.

Not Open Access | Targeting the olfactory bulb during experimental cerebral malaria

July 31, 2014 - 16:02 -- NOT Open Access
Laurent Rénia, Shanshan Wu Howland
Trends in Parasitology, Volume 30, Issue 8, August 2014, Pages 375-376

In a new study, Coban and colleagues provide new clues on the involvement of the olfactory bulb during experimental cerebral malaria in mice that open the way to testable hypotheses and potentially earlier intervention in humans.


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