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cerebral malaria

Lipid metabolites of the phospholipase A 2 pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

December 29, 2015 - 16:07 -- Open Access
Author(s): 
Vasiliki Pappa, Karl Seydel, Johanna Daily, et al.
Reference: 
Malaria Journal 2015, 14:513 (21 December 2015)

Taken together, paediatric CM brain volume was associated with products of the PLA 2 pathway and inflammatory cytokines.

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

November 19, 2015 - 06:32 -- Open Access
Author(s): 
Tovah N. Shaw, Phillip J. Stewart-Hutchinson, Michael L. Dustin, et al.
Reference: 
PLoS Pathog 11(11): e1005210

There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice

Nitrite therapy for cerebral malaria

November 12, 2015 - 08:34 -- Pierre Lutgen

A paper published twenty years ago should have attracted more attention (NM Anstey et al., J Exp Med 1996, 184, 557-567) : the suppression of NO synthesis in cerebral malaria appears to enhance pathogenesis and increased NO synthesis protects against clinical disease. The work was based on in vivo results obtained in Tanzanian children. Already five years earlier the killing of Plasmodium falciparum in vitro by nitric oxide derivatives (NO, nitrite, nitrate) had been demonstrated (KA Rockett et al., Infection and Immunity, 1991, 59, 3280-3283).

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

November 10, 2015 - 05:26 -- Open Access
Author(s): 
Sarah E. Hochman, Theresa F. Madaline, Kami Kim, et al.
Reference: 
mBio.01390-15, 22 September 2015 mBio vol. 6 no. 5 e01390-15

Cerebral malaria (CM) is a major contributor to malaria deaths, but its pathophysiology is not well understood.

NOT Open Access | Investigating proteasome inhibitors as potential adjunct therapies for experimental cerebral malaria

October 28, 2015 - 06:06 -- NOT Open Access
Author(s): 
S. W. Howland, G. X. P. Ng, S. K. Chia and L. Rénia
Reference: 
Parasite Immunology, Volume 37, Issue 11, pages 599–604, November 2015

Aside from antimalarials, there is currently no treatment for cerebral malaria, a fulminant neurological complication of P. falciparum infection that is a leading cause of death in African children.

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Not Open Access | Targeting glutamine metabolism rescues mice from late-stage cerebral malaria

October 27, 2015 - 07:25 -- NOT Open Access
Author(s): 
Emile B. Gordon, Geoffrey T. Hart, Susan K. Pierce, et al.
Reference: 
PNAS October 20, 2015 vol. 112 no. 42 13075-13080

The most deadly complication of Plasmodium falciparum infection is cerebral malaria (CM) with a case fatality rate of 15–25% in African children despite effective antimalarial chemotherapy.

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Plant Hormone Salicylic Acid Produced by a Malaria Parasite Controls Host Immunity and Cerebral Malaria Outcome

October 20, 2015 - 08:05 -- Open Access
Author(s): 
Ryuma Matsubara, Hiroka Aonuma, Mikiko Kojima, Michiru Tahara, Syed Bilal Ahmad Andrabi, Hitoshi Sakakibara, Kisaburo Nagamune
Reference: 
PLoS ONE 10(10): e0140559

The apicomplexan parasite Toxoplasma gondii produces the plant hormone abscisic acid, but it is unclear if phytohormones are produced by the malaria parasite Plasmodium spp., the most important parasite of this phylum.

The evidence for a role of vasospasm in the pathogenesis of cerebral malaria

October 14, 2015 - 10:58 -- Open Access
Author(s): 
Michael Eisenhut
Reference: 
Malaria Journal 2015, 14:405 (13 October 2015)

Due to delay in treatment, cerebral malaria (CM) remains a significant complication of Plasmodium falciparum infection and is a common cause of death from malaria.

Not Open Access | Artemisinin production by plant hairy root cultures in gas- and liquid-phase bioreactors

October 7, 2015 - 14:40 -- NOT Open Access
Author(s): 
Nivedita Patra, Ashok K. Srivastava
Reference: 
Plant Cell Reports

This study featured investigation of growth and artemisinin production by A. annua hairy roots (induced by Agrobacterium rhizogenes-mediated genetic transformation of explants) in three bioreactor configurations—bubble column reactor, NMB and modified NMB particularly to establish their suitability for commercial production.

NOT Open Access | Phenylhydrazine administration accelerates the development of experimental cerebral malaria

September 3, 2015 - 05:16 -- NOT Open Access
Author(s): 
Xiaotong Zhu, Jun Liu, Yonghui Feng, Wei Pang, Zanmei Qi, Yongjun Jiang, Hong Shang, Yaming Cao
Reference: 
Experimental Parasitology, Volume 156, September 2015, Pages 1–11

Phenylhydrazine (PHZ) treatment is generally used to enhance parasitemia in infected mice models.

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