Not Open Access | γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection
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PNAS May 14, 2019 116 (20) 9979-9988
Cerebral malaria (CM) is a major cause of death due to Plasmodium infection.
cerebral malaria
Not Open Access | MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice
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PNAS December 18, 2018 115 (51) E12024-E12033
The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy.
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Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria
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Reference:
Malaria Journal 2018 17:435, 26 November 2018
Severe brain swelling in paediatric CM was independent of tested blood pro-inflammatory and anti-inflammatory cytokines which are markers of systemic inflammation.
Not Open Access | Glucose metabolism mediates disease tolerance in cerebral malaria
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Reference:
PNAS October 23, 2018 115 (43) 11042-1104
Sickness behaviors are a conserved set of stereotypic responses to inflammatory diseases.
NOT Open Access | α-Tocopheryl succinate-suppressed development of cerebral malaria in mice
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Reference:
Parasitology Research, October 2018, Volume 117, Issue 10, pp 3177–3182
α-Tocopheryl succinate (α-TOS), a derivative of vitamin E, is synthesized by esterification of α-tocopherol.
Proteomic profiling of the plasma of Gambian children with cerebral malaria
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Malaria Journal 2018 17:337, 24 September 2018
The results indicate that increased tissue damage and hypercoagulability may play an important role in fatal CM.
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Not Open Access | Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria
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PNAS June 28, 2018. 201801737
Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.
Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes
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Reference:
Malaria Journal 2018 17:208, 22 May 2018
Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.
Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria
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Reference:
Malaria Journal 2018 17:192, 11 May 2018
These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.
NOT Open Access | Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells
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Reference:
Immunity Volume 48, Issue 4, 17 April 2018, Pages 760-772.e4
Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells.
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