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cerebral malaria

Not Open Access | γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection

May 20, 2019 - 14:31 -- NOT Open Access
Julie C. Ribot, Rita Neres, Ana Pamplona, et al.
PNAS May 14, 2019 116 (20) 9979-9988

Cerebral malaria (CM) is a major cause of death due to Plasmodium infection.

Not Open Access | MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice

December 20, 2018 - 03:27 -- NOT Open Access
Brittany A. Riggle, Sanhita Sinharay, Dima A. Hammoud, et al.
PNAS December 18, 2018 115 (51) E12024-E12033

The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy.

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Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria

November 27, 2018 - 15:33 -- Open Access
Visopo Harawa, Madi Njie, Stephen Rogerson, et al.
Malaria Journal 2018 17:435, 26 November 2018

Severe brain swelling in paediatric CM was independent of tested blood pro-inflammatory and anti-inflammatory cytokines which are markers of systemic inflammation.

Not Open Access | Glucose metabolism mediates disease tolerance in cerebral malaria

October 30, 2018 - 12:42 -- NOT Open Access
Andrew Wang, Sarah C. Huen, Harding H. Luan, Kelly Baker, Henry Rinder, Carmen J. Booth, and Ruslan Medzhitov
PNAS October 23, 2018 115 (43) 11042-1104

Sickness behaviors are a conserved set of stereotypic responses to inflammatory diseases.

NOT Open Access | α-Tocopheryl succinate-suppressed development of cerebral malaria in mice

October 2, 2018 - 16:33 -- NOT Open Access
Aiko Kume, Shunji Kasai, Hana Furuya & Hiroshi Suzuki
Parasitology Research, October 2018, Volume 117, Issue 10, pp 3177–3182

α-Tocopheryl succinate (α-TOS), a derivative of vitamin E, is synthesized by esterification of α-tocopherol.

Proteomic profiling of the plasma of Gambian children with cerebral malaria

September 25, 2018 - 15:15 -- Open Access
Ehab M. Moussa, Honglei Huang, Climent Casals-Pascual, et al.
Malaria Journal 2018 17:337, 24 September 2018

The results indicate that increased tissue damage and hypercoagulability may play an important role in fatal CM.


Not Open Access | Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

July 14, 2018 - 15:27 -- NOT Open Access
Patrick Strangward, Michael J. Haley, Kevin N. Couper, et al.
PNAS June 28, 2018. 201801737

Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

May 22, 2018 - 14:14 -- Open Access
Douglas G. Postels, Xiaoting Wu, Gretchen L. Birbeck, et al.
Malaria Journal 2018 17:208, 22 May 2018

Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.

Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria

May 15, 2018 - 14:35 -- Open Access
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E. R. Grau and Valery Combes
Malaria Journal 2018 17:192, 11 May 2018

These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.

NOT Open Access | Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

April 19, 2018 - 15:34 -- NOT Open Access
Kristina S. Burrack, Matthew A. Huggins, Sara E. Hamilton, et al.
Immunity Volume 48, Issue 4, 17 April 2018, Pages 760-772.e4

Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells.


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