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cerebral malaria

Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria

November 15, 2017 - 16:02 -- Open Access
Author(s): 
Anne Kessler, Selasi Dankwa, Kami Kim, et al.
Reference: 
Cell Host & Microbe Volume 22, Issue 5, 8 November 2017, Pages 601-614.e5

Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM).

A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration

November 14, 2017 - 15:53 -- Open Access
Author(s): 
Pedro Mejia, J. Humberto Treviño-Villarreal, Justin S. Reynolds, Mariana De Niz, Andrew Thompson, Matthias Marti and James R. Mitchell
Reference: 
Malaria Journal 2017 16:455, 9 November 2017

Rapamycin exerts pleotropic effects on host immunity, vascular activation and parasite sequestration that rescue mice from ECM, and thus support the potential clinical use of rapamycin as an adjunctive therapy in CM.

Cerebral malaria induces electrophysiological and neurochemical impairment in mice retinal tissue: possible effect on glutathione and glutamatergic system

November 2, 2017 - 15:52 -- Open Access
Author(s): 
Karen R. H. M. Oliveira, Nayara Kauffmann, Luana K. R. Leão, Adelaide C. F. Passos, Fernando A. F. Rocha, Anderson M. Herculano and José L. M. do Nascimento
Reference: 
Malaria Journal 2017 16:440, 2 November 2017

In summary, these findings indicate for the first time that CM induces neurochemical and electrophysiological impairment in the mice retinal tissue, in a TNF-independent manner.

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

August 2, 2017 - 17:01 -- Open Access
Author(s): 
Dag Holmberg, Elisabeth Franzén-Röhl, Chandy C. John, et al.
Reference: 
Malaria Journal 2017 16:303, 28 July 2017

CSF KYNA and kynurenine are elevated in children with CM, indicating an inhibition of glutamatergic and cholinergic signaling.

Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model

July 5, 2017 - 14:14 -- Open Access
Author(s): 
Onyango C. Odhiambo, Hannah N. Wamakima, Gabriel N. Magoma, Peter G. Kirira, Bonface J. Malala, Francis T. Kimani and Francis W. Muregi
Reference: 
Malaria Journal 2017 16:268, 3 July 2017

Covalent bitherapy proves to be a viable source of urgently needed new anti-malarials for management of cerebral malaria, and this polypharmacology approach could be a potential strategy to protect artesunate from parasite resistance and in potentially improving clinical outcomes in severe forms of malaria infections.

NOT Open Access | Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

June 21, 2017 - 15:38 -- NOT Open Access
Author(s): 
E. Shabani, B. J. Ouma, R. Idro, P. Bangirana, R. O. Opoka, G. S. Park, A. L. Conroy and C. C. John
Reference: 
Parasite Immunology, Volume 39, Issue 7, July 2017 e12438

Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration.

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria

May 10, 2017 - 15:27 -- Open Access
Author(s): 
Flora Reverchon, Stéphane Mortaud, Valérie F. J. Quesniaux, et al.
Reference: 
PLoS Pathog 13(4): e1006322

Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors.

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

December 22, 2016 - 12:38 -- Open Access
Author(s): 
Phillip A. Swanson II, Geoffrey T. Hart, Dorian B. McGavern, et al.
Reference: 
PLoS Pathog 12(12): e1006022

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children.

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NOT Open Access | Role of TGF-β and IL-6 in dendritic cells, Treg and Th17 mediated immune response during experimental cerebral malaria

November 2, 2016 - 08:06 -- NOT Open Access
Author(s): 
Tarun Keswani, Samrat Sarkar, Anirban Sengupta, Arindam Bhattacharyya
Reference: 
Cytokine, Volume 88, December 2016, Pages 154–166

The role of cytokines in Plasmodium infection have been extensively investigated, but pro and anti inflammatory cytokines mediated imbalance during malaria immune-pathogenesis is still unrevealed.

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