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cerebral malaria

Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria

May 11, 2016 - 16:14 -- Open Access
Neda Moradin, Sabrina Torre, Susan Gauthier, Mifong Tam, Jalal Hawari, Kirsten Vandercruyssen, Bart De Spiegeleer, Anny Fortin, Mary M. Stevenson and Philippe Gros
Malaria Journal 2016 15:260, 6 May 2016

These findings indicate that inclusion of Cys in current formulations of ACT, or its use as adjunct therapy could improve the anti-plasmodial activity of artemisinin, decrease mortality in cerebral malaria patients, and prevent or delay the development and spread of artemisinin resistance.

Medical Treatment: 

Early prediction of cerebral malaria by 1H NMR based metabolomics

April 12, 2016 - 16:56 -- Open Access
Soumita Ghosh, Arjun Sengupta, Shobhona Sharma and Haripalsingh M. Sonawat
Malaria Journal 2016 15:198, 12 April 2016

This study clearly demonstrates the possibility of differentiating and identifying animals with CM at an early, pre-clinical stage.

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

April 2, 2016 - 16:55 -- Open Access
Brandi D. Freeman, Yuri C. Martins, Oscar B. Akide-Ndunge, Fernando P. Bruno, Hua Wang, Herbert B. Tanowitz, David C. Spray, Mahalia S. Desruisseaux
PLoS Pathog 12(3): e1005477

Plasmodium falciparum infection causes a wide spectrum of diseases, including cerebral malaria, a potentially life-threatening encephalopathy.

Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort

April 2, 2016 - 16:19 -- Open Access
Richard Idro, Angelina Kakooza-Mwesige, Joyce Nalugya, et al.
Malaria Journal 2016 15:184, 31 March 2016

Cerebral malaria may predispose children to mental health disorders, possibly as a consequence of ischaemic neural injury.

NOT Open Access | New pentasubstituted pyrrole hybrid atorvastatin–quinoline derivatives with antiplasmodial activity

March 29, 2016 - 17:53 -- NOT Open Access
Rita C.C. Carvalho, Wagner A. Martins, Tayara P. Silva, Carlos R. Kaiser, Mônica M. Bastos, Luiz C.S. Pinheiro, Antoniana U. Krettli, Núbia Boechat
Bioorganic & Medicinal Chemistry Letters Volume 26, Issue 8, 15 April 2016, Pages 1881–1884

Cerebral malaria is caused by Plasmodium falciparum. Atorvastatin (AVA) is a pentasubstituted pyrrole, which has been tested as an adjuvant in the treatment of cerebral malaria.

NOT Open Access | Plasmodium vivax Malaria Presenting with Multifocal Hemorrhagic Brain Infarcts in a School-going Child

March 19, 2016 - 18:42 -- NOT Open Access
Santosh Kumar Rathia, Jhuma Sankar, Devasenathipathy Kandasamy, and Rakesh Lodha
J Trop Pediatr March 10, 2016

Cerebral malaria is a well-known complication of Plasmodium falciparum malaria.

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

March 9, 2016 - 09:16 -- Open Access
Catherine Manix Feintuch, Alex Saidi, Johanna P. Daily, et al.
mBio vol. 7 no. 1 e01300-15

Most patients with cerebral malaria (CM) sustain cerebral microvascular sequestration of Plasmodium falciparum-infected red blood cells (iRBCs).


A Single Human Cerebral Malaria Histopathologic Study Can Be Worth a Thousand Experiments

January 20, 2016 - 15:03 -- Open Access
David J. Sullivan, Jr.
mBio vol. 6 no. 6, 17 November 2015 , e01818-15

Severe malaria is a density-dependent disease that comprises infected-erythrocyte sequestration, with or without monocytic infiltration, as seen in renal, placental, and lung tissues from severe malaria patients.

Lipid metabolites of the phospholipase A 2 pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

December 29, 2015 - 16:07 -- Open Access
Vasiliki Pappa, Karl Seydel, Johanna Daily, et al.
Malaria Journal 2015, 14:513 (21 December 2015)

Taken together, paediatric CM brain volume was associated with products of the PLA 2 pathway and inflammatory cytokines.

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

November 19, 2015 - 06:32 -- Open Access
Tovah N. Shaw, Phillip J. Stewart-Hutchinson, Michael L. Dustin, et al.
PLoS Pathog 11(11): e1005210

There is significant evidence that brain-infiltrating CD8+ T cells play a central role in the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice


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