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cerebral malaria

A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration

November 14, 2017 - 15:53 -- Open Access
Pedro Mejia, J. Humberto Treviño-Villarreal, Justin S. Reynolds, Mariana De Niz, Andrew Thompson, Matthias Marti and James R. Mitchell
Malaria Journal 2017 16:455, 9 November 2017

Rapamycin exerts pleotropic effects on host immunity, vascular activation and parasite sequestration that rescue mice from ECM, and thus support the potential clinical use of rapamycin as an adjunctive therapy in CM.

Cerebral malaria induces electrophysiological and neurochemical impairment in mice retinal tissue: possible effect on glutathione and glutamatergic system

November 2, 2017 - 15:52 -- Open Access
Karen R. H. M. Oliveira, Nayara Kauffmann, Luana K. R. Leão, Adelaide C. F. Passos, Fernando A. F. Rocha, Anderson M. Herculano and José L. M. do Nascimento
Malaria Journal 2017 16:440, 2 November 2017

In summary, these findings indicate for the first time that CM induces neurochemical and electrophysiological impairment in the mice retinal tissue, in a TNF-independent manner.

Cerebrospinal fluid kynurenine and kynurenic acid concentrations are associated with coma duration and long-term neurocognitive impairment in Ugandan children with cerebral malaria

August 2, 2017 - 17:01 -- Open Access
Dag Holmberg, Elisabeth Franzén-Röhl, Chandy C. John, et al.
Malaria Journal 2017 16:303, 28 July 2017

CSF KYNA and kynurenine are elevated in children with CM, indicating an inhibition of glutamatergic and cholinergic signaling.

Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model

July 5, 2017 - 14:14 -- Open Access
Onyango C. Odhiambo, Hannah N. Wamakima, Gabriel N. Magoma, Peter G. Kirira, Bonface J. Malala, Francis T. Kimani and Francis W. Muregi
Malaria Journal 2017 16:268, 3 July 2017

Covalent bitherapy proves to be a viable source of urgently needed new anti-malarials for management of cerebral malaria, and this polypharmacology approach could be a potential strategy to protect artesunate from parasite resistance and in potentially improving clinical outcomes in severe forms of malaria infections.

NOT Open Access | Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

June 21, 2017 - 15:38 -- NOT Open Access
E. Shabani, B. J. Ouma, R. Idro, P. Bangirana, R. O. Opoka, G. S. Park, A. L. Conroy and C. C. John
Parasite Immunology, Volume 39, Issue 7, July 2017 e12438

Systemic tumour necrosis factor-α (TNF-α) may contribute to the pathogenesis of cerebral malaria (CM) by promoting endothelial activation and parasite sequestration.

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria

May 10, 2017 - 15:27 -- Open Access
Flora Reverchon, Stéphane Mortaud, Valérie F. J. Quesniaux, et al.
PLoS Pathog 13(4): e1006322

Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors.

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

December 22, 2016 - 12:38 -- Open Access
Phillip A. Swanson II, Geoffrey T. Hart, Dorian B. McGavern, et al.
PLoS Pathog 12(12): e1006022

Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection that results in thousands of deaths each year, mostly in African children.


NOT Open Access | Role of TGF-β and IL-6 in dendritic cells, Treg and Th17 mediated immune response during experimental cerebral malaria

November 2, 2016 - 08:06 -- NOT Open Access
Tarun Keswani, Samrat Sarkar, Anirban Sengupta, Arindam Bhattacharyya
Cytokine, Volume 88, December 2016, Pages 154–166

The role of cytokines in Plasmodium infection have been extensively investigated, but pro and anti inflammatory cytokines mediated imbalance during malaria immune-pathogenesis is still unrevealed.

NOT Open Access | Cerebral malaria in a man with Plasmodium vivax mono-infection: a case report

October 6, 2016 - 17:25 -- NOT Open Access
Himanshu Gupta, Pushwinder Dhunputh, Ankita N Bhatt, Kapaettu Satyamoorthy, and Shashikiran Umakanth
Trop Doct October 2016 vol. 46 no. 4 241-245

Cerebral malaria (CM) is a diffuse encephalopathy associated with coma and seizures commonly caused by Plasmodium falciparum (P. falciparum) in children with severe malaria.

Glucagon-like peptide-1 analogue, liraglutide, in experimental cerebral malaria: implications for the role of oxidative stress in cerebral malaria

August 26, 2016 - 17:57 -- Open Access
Brian DellaValle, Casper Hempel, Trine Staalsoe, Flemming Fryd Johansen and Jørgen Anders Lindholm Kurtzhals
Malaria Journal 2016 15:427, 24 August 2016

Despite the breadth of models where GLP-1 is neuroprotective, ECM was not affected by liraglutide providing important insight into the pathogenesis of ECM.


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