The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10204 malaria professionals are enjoying the free benefits of MalariaWorld today

cerebral malaria

Not Open Access | Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

July 14, 2018 - 15:27 -- NOT Open Access
Author(s): 
Patrick Strangward, Michael J. Haley, Kevin N. Couper, et al.
Reference: 
PNAS June 28, 2018. 201801737

Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

May 22, 2018 - 14:14 -- Open Access
Author(s): 
Douglas G. Postels, Xiaoting Wu, Gretchen L. Birbeck, et al.
Reference: 
Malaria Journal 2018 17:208, 22 May 2018

Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.

Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria

May 15, 2018 - 14:35 -- Open Access
Author(s): 
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E. R. Grau and Valery Combes
Reference: 
Malaria Journal 2018 17:192, 11 May 2018

These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.

NOT Open Access | Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

April 19, 2018 - 15:34 -- NOT Open Access
Author(s): 
Kristina S. Burrack, Matthew A. Huggins, Sara E. Hamilton, et al.
Reference: 
Immunity Volume 48, Issue 4, 17 April 2018, Pages 760-772.e4

Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells.

Cerebrospinal fluid Plasmodium falciparum histidine-rich protein-2 in pediatric cerebral malaria

March 27, 2018 - 15:47 -- Open Access
Author(s): 
Kiran T. Thakur, Jimmy Vareta, Karl B. Seydel, et al.
Reference: 
Malaria Journal 2018 17:125, 23 March 2018

Elevation of CSF, but not plasma PfHRP-2, is associated with death in this paediatric CM cohort. PfHRP-2 egress into the CSF may represent alteration of blood brain barrier permeability related to the sequestration of parasitized erythrocytes in the cerebral microvasculature.

NOT Open Access | Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis

February 1, 2018 - 16:15 -- NOT Open Access
Author(s): 
J. Palomo, V. F. J. Quesniaux, D. Togbe, F. Reverchon and B. Ryffel
Reference: 
Parasite Immunology, Volume 40, Issue 2, February 2018

Cerebral malaria (CM) is one complication of Plasmodium parasite infection that can lead to strong inflammatory immune responses in the central nervous system (CNS), accompanied by lung inflammation and anaemia.

Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65

January 10, 2018 - 15:38 -- Open Access
Author(s): 
Diletta Scaccabarozzi, Katrien Deroost, Yolanda Corbett, Natacha Lays, Paola Corsetto, Fausta Omodeo Salè, Philippe E. Van den Steen and Donatella Taramelli
Reference: 
Malaria Journal 2018 17:18, 9 January 2018

This study demonstrates that in C57BL/6J mice, depending on the parasite species, malaria-induced liver pathology results in different manifestations, which may contribute to the different outcomes.

Medical Condition: 

Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

November 15, 2017 - 16:08 -- Open Access
Author(s): 
Valerie M. Crowley, Kodjo Ayi, Ziyue Lu, Karen T. Liby, Michael Sporn and Kevin C. Kain
Reference: 
Malaria Journal 2017 16:463, 14 November 2017

These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.

Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria

November 15, 2017 - 16:02 -- Open Access
Author(s): 
Anne Kessler, Selasi Dankwa, Kami Kim, et al.
Reference: 
Cell Host & Microbe Volume 22, Issue 5, 8 November 2017, Pages 601-614.e5

Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM).

Pages

Subscribe to RSS - cerebral malaria