Not Open Access | Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria
Reference:
PNAS June 28, 2018. 201801737
Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.
cerebral malaria
Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes
Tags:
Reference:
Malaria Journal 2018 17:208, 22 May 2018
Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.
Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria
Tags:
Reference:
Malaria Journal 2018 17:192, 11 May 2018
These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.
NOT Open Access | Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells
Tags:
Reference:
Immunity Volume 48, Issue 4, 17 April 2018, Pages 760-772.e4
Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells.
Cerebrospinal fluid Plasmodium falciparum histidine-rich protein-2 in pediatric cerebral malaria
Tags:
Reference:
Malaria Journal 2018 17:125, 23 March 2018
Elevation of CSF, but not plasma PfHRP-2, is associated with death in this paediatric CM cohort. PfHRP-2 egress into the CSF may represent alteration of blood brain barrier permeability related to the sequestration of parasitized erythrocytes in the cerebral microvasculature.
Organization:
NOT Open Access | Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis
Tags:
Reference:
Parasite Immunology, Volume 40, Issue 2, February 2018
Cerebral malaria (CM) is one complication of Plasmodium parasite infection that can lead to strong inflammatory immune responses in the central nervous system (CNS), accompanied by lung inflammation and anaemia.
Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65
Reference:
Malaria Journal 2018 17:18, 9 January 2018
This study demonstrates that in C57BL/6J mice, depending on the parasite species, malaria-induced liver pathology results in different manifestations, which may contribute to the different outcomes.
Medical Condition:
Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria
Reference:
Malaria Journal 2017 16:463, 14 November 2017
These results indicate that SO are a new class of immunomodulatory drugs and support further studies investigating this class of agents as potential adjunctive therapy for severe malaria.
Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria
Tags:
Reference:
Cell Host & Microbe Volume 22, Issue 5, 8 November 2017, Pages 601-614.e5
Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM).
Getting Your Head around Cerebral Malaria
Tags:
Reference:
Cell Host & Microbe, Volume 22, Issue 5, 8 November 2017, Pages 586-588
Cerebral malaria is one of the most severe complications of human infection by the Plasmodium falciparum parasite.
Pages
