Breakdown of the blood brain barrier (BBB) is a feature of cerebral malaria (CM), a manifestation of infection with Plasmodium falciparum parasites that currently has a 20% fatality rate and disproportionately affects children under 5 years old.
Cerebral malaria (CM) is a major cause of death due to Plasmodium infection.
The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy.
Severe brain swelling in paediatric CM was independent of tested blood pro-inflammatory and anti-inflammatory cytokines which are markers of systemic inflammation.
Sickness behaviors are a conserved set of stereotypic responses to inflammatory diseases.
α-Tocopheryl succinate (α-TOS), a derivative of vitamin E, is synthesized by esterification of α-tocopherol.
The results indicate that increased tissue damage and hypercoagulability may play an important role in fatal CM.
Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.
Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.
These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.