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cerebral malaria

Blood brain barrier disruption in cerebral malaria: Beyond endothelial cell activation

July 16, 2019 - 16:18 -- Open Access
Author(s): 
Arnulfo Tunon-Ortiz, Tracey J. Lamb
Reference: 
PLoS Pathog 15(6): e1007786

Breakdown of the blood brain barrier (BBB) is a feature of cerebral malaria (CM), a manifestation of infection with Plasmodium falciparum parasites that currently has a 20% fatality rate and disproportionately affects children under 5 years old.

Not Open Access | γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection

May 20, 2019 - 14:31 -- NOT Open Access
Author(s): 
Julie C. Ribot, Rita Neres, Ana Pamplona, et al.
Reference: 
PNAS May 14, 2019 116 (20) 9979-9988

Cerebral malaria (CM) is a major cause of death due to Plasmodium infection.

Not Open Access | MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice

December 20, 2018 - 03:27 -- NOT Open Access
Author(s): 
Brittany A. Riggle, Sanhita Sinharay, Dima A. Hammoud, et al.
Reference: 
PNAS December 18, 2018 115 (51) E12024-E12033

The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy.

Medical Treatment: 

Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria

November 27, 2018 - 15:33 -- Open Access
Author(s): 
Visopo Harawa, Madi Njie, Stephen Rogerson, et al.
Reference: 
Malaria Journal 2018 17:435, 26 November 2018

Severe brain swelling in paediatric CM was independent of tested blood pro-inflammatory and anti-inflammatory cytokines which are markers of systemic inflammation.

Not Open Access | Glucose metabolism mediates disease tolerance in cerebral malaria

October 30, 2018 - 12:42 -- NOT Open Access
Author(s): 
Andrew Wang, Sarah C. Huen, Harding H. Luan, Kelly Baker, Henry Rinder, Carmen J. Booth, and Ruslan Medzhitov
Reference: 
PNAS October 23, 2018 115 (43) 11042-1104

Sickness behaviors are a conserved set of stereotypic responses to inflammatory diseases.

NOT Open Access | α-Tocopheryl succinate-suppressed development of cerebral malaria in mice

October 2, 2018 - 16:33 -- NOT Open Access
Author(s): 
Aiko Kume, Shunji Kasai, Hana Furuya & Hiroshi Suzuki
Reference: 
Parasitology Research, October 2018, Volume 117, Issue 10, pp 3177–3182

α-Tocopheryl succinate (α-TOS), a derivative of vitamin E, is synthesized by esterification of α-tocopherol.

Proteomic profiling of the plasma of Gambian children with cerebral malaria

September 25, 2018 - 15:15 -- Open Access
Author(s): 
Ehab M. Moussa, Honglei Huang, Climent Casals-Pascual, et al.
Reference: 
Malaria Journal 2018 17:337, 24 September 2018

The results indicate that increased tissue damage and hypercoagulability may play an important role in fatal CM.

Person: 

Not Open Access | Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

July 14, 2018 - 15:27 -- NOT Open Access
Author(s): 
Patrick Strangward, Michael J. Haley, Kevin N. Couper, et al.
Reference: 
PNAS June 28, 2018. 201801737

Cerebral malaria (CM) is a serious neurological complication caused by Plasmodium falciparum infection.

Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

May 22, 2018 - 14:14 -- Open Access
Author(s): 
Douglas G. Postels, Xiaoting Wu, Gretchen L. Birbeck, et al.
Reference: 
Malaria Journal 2018 17:208, 22 May 2018

Despite substantial demographic and clinical heterogeneity between subjects in Malawi and Uganda as well as different EEG readers at each site, EEG findings on admission predicted mortality and morbidity.

Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria

May 15, 2018 - 14:35 -- Open Access
Author(s): 
Amy Cohen, Anna Zinger, Natalia Tiberti, Georges E. R. Grau and Valery Combes
Reference: 
Malaria Journal 2018 17:192, 11 May 2018

These data suggest that, in the mouse model at least, miRNA may have a regulatory role in the pathogenesis of severe malaria.

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