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prevalence

Use of real-time multiplex PCR, malaria rapid diagnostic test and microscopy to investigate the prevalence of Plasmodium species among febrile hospital patients in Sierra Leone

February 25, 2020 - 15:56 -- Open Access
Author(s): 
Tomasz A. Leski, Chris Rowe Taitt, David A. Stenger, et al.
Reference: 
Malaria Journal 2020 19:84, 21 February 2020

Malaria continues to affect over 200 million individuals every year, especially children in Africa. Rapid and sensitive detection and identification of Plasmodium parasites is crucial for treating patients and monitoring of control efforts. Compared to traditional diagnostic methods such as microscopy and rapid diagnostic tests (RDTs), DNA based methods, such as polymerase chain reaction (PCR) offer significantly higher sensitivity, definitive discrimination of Plasmodium species, and detection of mixed infections. While PCR is not currently optimized for routine diagnostics, its role in epidemiological studies is increasing as the world moves closer toward regional and eventually global malaria elimination. This study demonstrates the field use of a novel, ambient temperature-stabilized, multiplexed PCR assay in a small hospital setting in Sierra Leone.

Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic review and meta-analysis

February 3, 2020 - 16:36 -- Open Access
Author(s): 
Loick P. Kojom and Vineeta Singh
Reference: 
Malaria Journal 2020 19:46, 28 January 2020

In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. However, the chances of RDT-oriented successful treatment are increasingly jeopardized by the appearance of mutants with deletions in pfhrp2 and pfhrp3 genes. This systematic review and meta-analysis determines the prevalence of field P. falciparum isolates with deletion in pfhrp2 and/or pfhrp3 genes and their proportion among false-negative results in the PfHRP2-based RDTs in SSA and India.

Prevalence of malaria and its risk factors in Sabah Malaysia

December 2, 2019 - 15:00 -- Open Access
Author(s): 
Abdul Rahman R, Aniza I, Zetty Sofia MZ
Reference: 
International Journal of Infectious Diseases 2019 Nov 27. pii: S1201-9712(19)30466-7.

This study aims to determine the prevalence of malaria in Sabah and its potential risk factors.

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Prevalence of Plasmodium spp. in the Amazonian Border Context (French Guiana-Brazil): Associated Factors and Spatial Distribution

November 27, 2019 - 16:08 -- Open Access
Author(s): 
Mosnier E, Roux E, Musset L, et al.
Reference: 
Am. J. Trop. Med. Hyg., 00(0), 2019, pp. 1–12

To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l’Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR).

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Prevalence and distribution of G6PD deficiency: implication for the use of primaquine in malaria treatment in Ethiopia

October 8, 2019 - 14:57 -- Open Access
Author(s): 
Eugenia Lo, Daibin Zhong, Beka Raya, Kareen Pestana, Cristian Koepfli, Ming-Chieh Lee, Delenasaw Yewhalaw and Guiyun Yan
Reference: 
Malaria Journal 2019 18:340, 7 October 2019

G6PD enzyme deficiency is a common enzymatic X-linked disorder. Deficiency of the G6PD enzyme can cause free radical-mediated oxidative damage to red blood cells, leading to premature haemolysis. Treatment of Plasmodium vivax malaria with primaquine poses a potential risk of mild to severe acute haemolytic anaemia in G6PD deficient people. In this study, the prevalence and distribution of G6PD mutations were investigated across broad areas of Ethiopia, and tested the association between G6PD genotype and phenotype with the goal to provide additional information relevant to the use of primaquine in malaria treatment.

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WHO should measure the prevalence of malaria in Africa

March 8, 2012 - 19:56 -- Bart G.J. Knols

The article below was written by Dr. Bill Jobin and first posted as a comment under the most recent poll. I elevated it to a Guest editorial.

 

It is unfortunate that we have recently seen a great deal of confusion about the amount of malaria in Africa.  The confusion arises because most of the people making the estimates are not scientists but artists; computer artists.  It would be better if we relied on scientists.  Computer artists, using their own data and their own inspirations, get varying answers and generate conflicting maps and graphs.  But scientists, using standardized techniques and randomized sampling, get the same answers, no matter who is doing the work.  We urgently need accurate numbers on malaria...

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