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NOT Open Access | High genetic complexity but low relatedness in Plasmodium falciparum infections from Western Savannah Highlands and coastal equatorial Lowlands of Cameroon

July 28, 2021 - 14:12 -- NOT Open Access
Atuh NI, Anong DN, Jerome FC, Oriero E, Mohammed NI, D'Alessandro U, Amambua-Ngwa A
Pathog Glob Health. 2021 Jul 26:1-10

To determine the diversity and connectivity of infections in Northwestern and Southwestern Cameroon, 232 Plasmodium falciparum infections, collected in 2018 from the Ndop Health District (NHD) in the western savannah highlands in the Northwest and the Limbe Health District (LHD) in the coastal lowland forests in the Southwest of Cameroon were genotyped for nine neutral microsatellite markers.

Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction

June 16, 2021 - 13:17 -- Open Access
Eimear Cleary, Manuel W. Hetzel, Paul Siba, Colleen L. Lau and Archie C. A. Clements
Malaria Journal 2021 20:269, 13 June 2021

Considerable progress towards controlling malaria has been made in Papua New Guinea through the national malaria control programme’s free distribution of long-lasting insecticidal nets, improved diagnosis with rapid diagnostic tests and improved access to artemisinin combination therapy. Predictive prevalence maps can help to inform targeted interventions and monitor changes in malaria epidemiology over time as control efforts continue. This study aims to compare the predictive performance of prevalence maps generated using Bayesian decision network (BDN) models and multilevel logistic regression models (a type of generalized linear model, GLM) in terms of malaria spatial risk prediction accuracy.

Impact of Community-Based Mass Testing and Treatment on Malaria Infection Prevalence in a High-Transmission Area of Western Kenya: A Cluster Randomized Controlled Trial

June 8, 2021 - 10:49 -- Open Access
Samuels AM, Odero NA, Desai MR, et al.
Clin Infect Dis. 2021 Jun 1;72(11):1927-1935 

Global gains toward malaria elimination have been heterogeneous and have recently stalled. Interventions targeting afebrile malaria infections may be needed to address residual transmission. We studied the efficacy of repeated rounds of community-based mass testing and treatment (MTaT) on malaria infection prevalence in western Kenya.

Fine-scale variation in malaria prevalence across ecological regions in Madagascar: a cross-sectional study

June 1, 2021 - 15:27 -- Open Access
Rice BL, Golden CD, Hartl DL, et al.
BMC Public Health. 2021 May 29;21(1):1018

Large-scale variation in ecological parameters across Madagascar is hypothesized to drive varying spatial patterns of malaria infection. However, to date, few studies of parasite prevalence with resolution at finer, sub-regional spatial scales are available. As a result, there is a poor understanding of how Madagascar’s diverse local ecologies link with variation in the distribution of infections at the community and household level. Efforts to preserve Madagascar’s ecological diversity often focus on improving livelihoods in rural communities near remaining forested areas but are limited by a lack of data on their infectious disease burden.

Prevalence of clinical malaria and household characteristics of patients in tribal districts of Pakistan

May 5, 2021 - 11:32 -- Open Access
Karim AM, Yasir M, Ali T, Malik SK, Ullah I, Qureshi NA, Yuanting H, Azhar EI, Jin HJ
PLoS Negl Trop Dis. 2021 May 3;15(5):e0009371

Malaria, disproportionately affects poor people more than any other disease of public health concern in developing countries. In resource-constrained environments, monitoring the occurrence of malaria is essential for the success of national malaria control programs. Militancy and military conflicts have been a major challenge in monitoring the incidence and controlling malaria and other emerging infectious diseases. The conflicts and instability in Afghanistan have resulted in the migration of refugees into the war-torn tribal districts of Pakistan’s Khyber Pakhtunkhwa (KPK) province and the possible introduction of many contagious epidemics. Although malaria is very common in all tribal districts, molecular, clinical and epidemiological data are scarce in these high-burden districts. Therefore, for the proper surveillance, detection, and control of malaria, obtaining and analyzing reliable data in these districts is essential.

NOT Open Access | Prevalence of Cardiovascular Complications in Malaria: A Systematic Review and Meta-Analysis

March 17, 2021 - 17:03 -- NOT Open Access
Holm AE, Gomes LC, Farias Marinho CR, Silvestre OM, Vestergaard LS, Biering-Sørensen T, Brainin P
Am J Trop Med Hyg. 2021 Mar 15:tpmd201414

Recent studies have suggested that malaria may affect the cardiovascular system. The aim of this systematic review and meta-analysis was to determine the prevalence of cardiovascular complications in symptomatic malaria patients. We searched databases such as Pubmed, Embase, Cochrane, and Web of Science (January 1950-April 2020) for studies reporting on cardiovascular complications in adults and children with malaria.

NOT Open Access | Prevalence and association of malaria with ABO blood group and hemoglobin level in individuals visiting Mekaneeyesus Primary Hospital, Estie District, northwest Ethiopia: a cross-sectional study

March 4, 2021 - 11:11 -- NOT Open Access
Tazebew B, Munshea A, Nibret E
Parasitol Res. 2021 Mar 3

Malaria is a serious and sometimes fatal mosquito-borne disease caused by protozoan parasite of the genus Plasmodium. ABO blood group antigens represent polymorphic traits inherited among individuals and populations. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. This study was undertaken to determine the prevalence of malaria and its possible association with ABO blood group and hemoglobin level among individuals attending Mekaneeyesus Primary Hospital, Estie District, northwestern Ethiopia.

Prevalence of malaria and associated factors among under-five children in Sherkole refugee camp, Benishangul-Gumuz region, Ethiopia. A cross-sectional study

February 23, 2021 - 14:03 -- Open Access
Ahmed A, Mulatu K, Elfu B
PLoS One. 2021 Feb 19;16(2):e0246895

Under-five year children are the most vulnerable group affected by malaria, they accounted for 61% of all malaria deaths worldwide. Sherkole refugee camp is stratified under high risk for malaria. Knowledge on malaria prevalence and associated factors among under-five children in Sherkole refugee camp is lacking.

Multi-Indicator and Multistep Assessment of Malaria Transmission Risks in Western Kenya

February 10, 2021 - 09:41 -- Open Access
Zhou G, Zhong D, Lee MC, Wang X, Atieli HE, Githure JI, Githeko AK, Kazura J, Yan G
Am J Trop Med Hyg. 2021 Feb 8:tpmd201211

Malaria risk factor assessment is a critical step in determining cost-effective intervention strategies and operational plans in a regional setting. We develop a multi-indicator multistep approach to model the malaria risks at the population level in western Kenya. We used a combination of cross-sectional seasonal malaria infection prevalence, vector density, and cohort surveillance of malaria incidence at the village level to classify villages into malaria risk groups through unsupervised classification. Generalized boosted multinomial logistics regression analysis was performed to determine village-level risk factors using environmental, biological, socioeconomic, and climatic features.

Molecular characterization of G6PD mutations reveals the high frequency of G6PD Aures in the Lao Theung population

January 13, 2021 - 09:57 -- Open Access
Amkha Sanephonasa, Chalisa Louicharoen Cheepsunthorn, Naly Khaminsou, Onekham Savongsy, Issarang Nuchprayoon and Kamonlak Leecharoenkiat
Malaria Journal 2021 20:30, 7 January 2021

The prevalence and genotypes of G6PD deficiency vary worldwide, with higher prevalence in malaria endemic areas. The first-time assessment of G6PD deficiency prevalence and molecular characterization of G6PD mutations in the Lao Theung population were performed in this study.


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