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Molecular characterization of G6PD mutations reveals the high frequency of G6PD Aures in the Lao Theung population

January 13, 2021 - 09:57 -- Open Access
Amkha Sanephonasa, Chalisa Louicharoen Cheepsunthorn, Naly Khaminsou, Onekham Savongsy, Issarang Nuchprayoon and Kamonlak Leecharoenkiat
Malaria Journal 2021 20:30, 7 January 2021

The prevalence and genotypes of G6PD deficiency vary worldwide, with higher prevalence in malaria endemic areas. The first-time assessment of G6PD deficiency prevalence and molecular characterization of G6PD mutations in the Lao Theung population were performed in this study.

Is the source of domestic water associated with the risk of malaria infection? Spatial variability and a mixed-effects multilevel analysis

December 29, 2020 - 15:41 -- Open Access
Shayo FK, Nakamura K, Saber AS, Seino K
Int J Infect Dis. 2020 Dec 23:S1201-9712(20)32585-6

There is a dearth of information about the influence of sources of domestic water and malaria infection in endemic regions such as Tanzania. This study examined geospatial variability and association between the source of domestic water and the malaria prevalence in Tanzania.

NOT Open Access | Diarrhea in Children with Plasmodium falciparum Malaria: A Case-Control Study on the Prevalence and Response to Antimalarial Treatment

December 16, 2020 - 10:10 -- NOT Open Access
Lo Vecchio A, Basile FW, Bruzzese D, Di Dato F, Aol P, Omona V, Smarrazzo A, Guarino A
Am J Trop Med Hyg. 2020 Dec 14

The role of Plasmodium in the etiology of acute diarrhea in developing countries remains controversial, and gastrointestinal (GI) symptoms are inconsistently reported in malaria. In this observational case-control study, we investigated the prevalence and risk factors for GI symptoms in hospitalized malarious children aged 1 month to 5 years in northern Uganda. Children with a diagnosis of Plasmodium falciparum malaria were enrolled as cases, and feverish children in whom malaria was excluded were enrolled as controls.

Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda

November 12, 2020 - 15:47 -- Open Access
Orishaba P, Kalyango JN, Nankabirwa JI, et al.
PLoS One. 2020 Nov 11;15(11):e0240838

Although WHO recommends cotrimoxazole (CTX) discontinuation among HIV patients who have undergone immune recovery and are living in areas of low prevalence of malaria, some countries including Uganda recommend CTX discontinuation despite having a high malaria burden. We estimated the prevalence and factors associated with malaria parasitaemia among adults living with HIV attending hospital outpatient clinic before and after discontinuation of CTX prophylaxis.

Prevalence and Risk Factors Associated with Malaria among Children Aged Six Months to 14 Years Old in Rwanda: Evidence from 2017 Rwanda Malaria Indicator Survey

November 4, 2020 - 15:13 -- Open Access
Habyarimana F, Ramroop S
Int J Environ Res Public Health. 2020 Oct 30;17(21):E7975

Malaria is a major public health risk in Rwanda where children and pregnant women are most vulnerable. This infectious disease remains the main cause of morbidity and mortality among children in Rwanda. The main objectives of this study were to assess the prevalence of malaria among children aged six months to 14 years old in Rwanda and to identify the factors associated with malaria in this age group.

Malaria in children and women of childbearing age: infection prevalence, knowledge and use of malaria prevention tools in the province of Nyanga, Gabon

November 4, 2020 - 10:00 -- Open Access
Roméo Karl Imboumy-Limoukou, Sydney Maghendji-Nzondo, Jean-Bernard Lekana-Douki, et al.
Malaria Journal 2020 19:387, 2 November 2020

There is little information on the social perception of malaria and the use of preventative measures in Gabon, especially in rural areas. Adequate knowledge of malaria prevention and control can help in reducing the burden of malaria among vulnerable groups, particularly pregnant women and children under 5 years old living in malaria-endemic settings. This study was designed to assess the prevalence of malaria and the knowledge and attitude towards this disease in households in Nyanga Province.

Spatiotemporal mapping of malaria prevalence in Madagascar using routine surveillance and health survey data

October 28, 2020 - 08:42 -- Open Access
Arambepola R, Keddie SH, Cameron E, et al.
Sci Rep. 2020 Oct 22;10(1):18129

Malaria transmission in Madagascar is highly heterogeneous, exhibiting spatial, seasonal and long-term trends. Previous efforts to map malaria risk in Madagascar used prevalence data from Malaria Indicator Surveys. These cross-sectional surveys, conducted during the high transmission season most recently in 2013 and 2016, provide nationally representative prevalence data but cover relatively short time frames.

The relationship between facility-based malaria test positivity rate and community-based parasite prevalence

October 8, 2020 - 08:01 -- Open Access
Kamau A, Mtanje G, Mataza C, Malla L, Bejon P, Snow RW
PLoS One. 2020 Oct 7;15(10):e0240058

Malaria surveillance is a key pillar in the control of malaria in Africa. The value of using routinely collected data from health facilities to define malaria risk at community levels remains poorly defined.

NOT Open Access | Asymptomatic Malaria Co-infection of HIV-infected Adults in Nigeria. Prevalence of and Impact on Cognition, Mood and Biomarkers of Systemic Inflammation

October 7, 2020 - 15:43 -- NOT Open Access
Bharti AR, McCutchan JA, Umlauf A, Okwuegbuna OK, Letendre S, Cherner M, Burdo T, Jumare J, Williams K, Blattner W, Royal W
J Acquir Immune Defic Syndr. 2020 Oct 1

HIV and malaria are associated with immunological perturbations and neurocognitive disorders even when asymptomatic. However, the effect of asymptomatic malaria (AM) in HIV-infected adults on neurocognitive impairment (NCI) is not well understood. This study investigated the biomarkers of systemic inflammation and neurocognition in dually-infected Nigerian adults.

Data-driven malaria prevalence prediction in large densely populated urban holoendemic sub-Saharan West Africa

September 30, 2020 - 11:48 -- Open Access
Brown BJ, Manescu P, Fernandez-Reyes D, et al.
Sci Rep. 2020 Sep 28;10(1):15918

Over 200 million malaria cases globally lead to half-million deaths annually. The development of malaria prevalence prediction systems to support malaria care pathways has been hindered by lack of data, a tendency towards universal "monolithic" models (one-size-fits-all-regions) and a focus on long lead time predictions. Current systems do not provide short-term local predictions at an accuracy suitable for deployment in clinical practice.


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