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transgenic mosquito

Accumulation of the Uncommon: OX513A Releases and Genome Introgression

September 30, 2019 - 08:00 -- Mark Benedict

A paper that appeared in Scientific Reports by Evans et al. (1)asked whether changes in the genotypes of target mosquito populations would occur due to introgression of released transgenic mosquito genomes. The paper in fact describes the introgression of released mosquito strain genome into wild populations of Aedes aegypti after releases of the OX513A strain developed by Oxitec and the paper has generated a lot of controversy. Is this a surprising finding or an entirely predictable outcome? Is it cause for alarm?

Size matters: Do ‘large cages’ for mosquito trials have any objectively meaningful dimensions?

August 26, 2019 - 14:25 -- Mark Benedict

Teams testing mosquitoes that are being considered for field release, their advisors, policy makers and donors often talk about ‘large cage trials’, but how large must a cage be for mosquito trials to qualify for that title? Is the proper metric its volume or stimulation of behavioral characteristics for a cage that provides the data we need? Perhaps the real value of large cage testing is neither of these but its independence.

Guest Editorial: Scientific standards and the release of genetically modified insects for vector control

February 28, 2012 - 21:11 -- Bart G.J. Knols

This guest editorial was written by Dr. Guy Reeves of the Max-Planck institute in Plön, Germany.

 
Field trials of genetically modified Aedes aegypti mosquitoes have already progressed to free releases in populated areas in a number of countries. A recent publication in PLoS NTD provides a critical summary of the events leading up to these trials and is aimed at non-specialist readers. While advocating the value of field testing transgenic techniques for suppressing disease vector populations, it highlights a number of troubling scientific precedents.
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