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malaria elimination

The prevalence of glucose-6-phosphate dehydrogenase deficiency in the Cape Verdean population in the context of malaria elimination

March 19, 2020 - 08:44 -- Open Access
Author(s): 
DePina AJ, Pires CM, Andrade AJB, Dia AK, Moreira AL, Ferreira MCM, Correia AJ, Faye O, Seck I, Niang EHA
Reference: 
PLoS One. 2020 Mar 16; 15(3):e0229574

Cabo Verde aims to eliminate malaria by 2020. In the country, Plasmodium falciparum had been the main parasite responsible for indigenous cases and primaquine is the first line treatment of cases and for radical cure. However, the lack of knowledge of the national prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may be one of the constraints to the malaria elimination process. Hence, this first study determines the prevalence of G6PD deficiency (G6PDd) in the archipelago.

NOT Open Access | Tafenoquine: A step toward malaria elimination

February 24, 2020 - 14:18 -- NOT Open Access
Author(s): 
Lu KY, Derbyshire ER
Reference: 
Biochemistry. 2020 Feb 19

There is a pressing need for compounds with broad-spectrum activity against malaria parasites at different life cycle stages to achieve malaria elimination. However, this goal cannot be accomplished without targeting the tenacious dormant liver stage hypnozoite that causes multiple relapses after the first episode of illness. In search for the magic bullet to radically cure Plasmodium vivax malaria, tafenoquine outperformed other candidate drugs and was approved by the US Food and Drug Administration in 2018. Tafenoquine is an 8-aminoquinoline that inhibits multiple life stages of different Plasmodium species.

Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination

February 17, 2020 - 14:54 -- Open Access
Author(s): 
Ngassa Mbenda HG, Wang M, Guo J, Siddiqui FA, Hu Y, Yang Z, Kittichai V, Sattabongkot J, Cao Y, Jiang L, Cui L
Reference: 
Parasit Vectors. 2020 Feb 12;13(1):67

The malaria elimination plan of the Greater Mekong Subregion (GMS) is jeopardized by the increasing number of Plasmodium vivax infections and emergence of parasite strains with reduced susceptibility to the frontline drug treatment chloroquine/primaquine. This study aimed to determine the evolution of the P. vivax multidrug resistance 1 (Pvmdr1) gene in P. vivax parasites isolated from the China–Myanmar border area during the major phase of elimination.

Challenges in early phase of implementing the 1-3-7 surveillance and response approach in malaria elimination setting: A field study from Myanmar

February 14, 2020 - 16:46 -- Open Access
Author(s): 
Aung PP, Thein ZW, Hein ZNM, Aung KT, Mon NO, Linn NYY, Thi A, Wai KT, Maung TM
Reference: 
Infect Dis Poverty. 2020 Feb 10;9(1):18

The National Plan for Malaria Elimination (NPME) in Myanmar (2016–2030) aims to eliminate indigenous Plasmodium falciparum malaria in six states/regions of low endemicity by 2020 and countrywide by 2030. To achieve this goal, in 2016 the National Malaria Control Program (NMCP) implemented the “1-3-7” surveillance and response strategy. This study aims to identify the barriers to successful implementation of the NPME which emerged during the early phase of the “1-3-7” approach deployment.

The resistome and genomic reconnaissance in the age of malaria elimination

January 15, 2020 - 09:06 -- Open Access
Author(s): 
Kümpornsin K, Kochakarn T, Chookajorn T
Reference: 
Disease Models & Mechanisms, vol. 12 no. 12, dmm040717

Malaria is an infectious disease caused by parasitic protozoa in the Plasmodium genus. A complete understanding of the biology of these parasites is challenging in view of their need to switch between the vertebrate and insect hosts. The parasites are also capable of becoming highly motile and of remaining dormant for decades, depending on the stage of their life cycle.

Understanding challenges to malaria elimination in Nepal: a qualitative study with an embedded capacity-building exercise

December 30, 2019 - 14:32 -- Open Access
Author(s): 
Shiva Raj Adhikari, Vishnu P. Sapkota, Arjun K. Thapa and Yubraj Acharya
Reference: 
Malaria Journal 2019 18:437, 21 December 2019

The Nepalese Government has made significant progress toward the elimination of malaria. However, given the surge in the prevalence of non-communicable diseases, such as diabetes and hypertension, and the localized nature of malaria prevalence, malaria elimination will remain a challenge. In the current study, the authors sought to understand local perceptions on threats to malaria elimination in three endemic districts.

The 2019 Isdell:Flowers Cross Border Malaria Initiative Round Table: community engagement in the context of malaria elimination

December 30, 2019 - 14:19 -- Open Access
Author(s): 
Alexandra Gordon, Rebecca J. Vander Meulen and Alysse Maglior
Reference: 
Malaria Journal 2019 18:432, 19 December 2019

Government officials, representatives from malaria endemic communities, and nonprofit, academic, and private sector partners convened at the 2019 Isdell:Flowers Cross Border Malaria Initiative Round Table in Livingstone, Zambia from February 28–March 1, 2019 to discuss the necessity of community engagement and the involvement of those directly affected by malaria in malaria elimination efforts.

Assessing the role of the private sector in surveillance for malaria elimination in Haiti and the Dominican Republic: a qualitative study

December 10, 2019 - 10:58 -- Open Access
Author(s): 
Sidibe A, Maglior A, Bennett A, et al.
Reference: 
Malar J. 2019 Dec 5; 18(1):408

Haiti and the Dominican Republic (DR) are targeting malaria elimination by 2022. The private health sector has been relatively unengaged in these efforts, even though most primary health care in Haiti is provided by non-state actors, and many people use traditional medicine. Data on private health sector participation in malaria elimination efforts are lacking, as are data on care-seeking behaviour of patients in the private health sector. This study sought to describe the role of private health sector providers, care-seeking behaviour of individuals at high risk of malaria, and possible means of engaging the private health sector in Hispaniola’s malaria elimination efforts.

NOT Open Access |Recent advances in transmission-blocking drugs for malaria elimination

December 2, 2019 - 15:10 -- NOT Open Access
Author(s): 
Wadi I, Nath M, Anvikar AR, Singh P, Sinha A.
Reference: 
Future Med Chem. 2019 Nov 29.

The scientific community worldwide has realized that malaria elimination will not be possible without development of safe and effective transmission-blocking interventions. Primaquine, the only WHO recommended transmission-blocking drug, is not extensively utilized because of the toxicity issues in G6PD deficient individuals.

Forest work and its implications for malaria elimination: a qualitative study

December 2, 2019 - 14:50 -- Open Access
Author(s): 
Sanann N, Peto TJ, Pell C, et al.
Reference: 
Malaria Journal volume 18, Article number: 376 (2019)

Over the last 20 years, malaria incidence has decreased across the Greater Mekong Sub-region (GMS) and the emergence of artemisinin resistance has stimulated efforts to accelerate regional elimination. In the GMS, the malaria transmission is focused increasingly in forested zones. This article describes forest-going activities and examines forest workers’ attitudes to and experiences of malaria prevention and control in north-eastern Cambodia.

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