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malaria elimination

Guest editorial: “End Malaria for Good”- a few key messages based on the Cambodian experience

June 23, 2016 - 07:27 -- Bart G.J. Knols
The editorial below was contributed by Sara E Canavati and Jack S Richards. Contact details below.
World Malaria Day (WMD) is an international observance established in 2007 and commemorated every year on 25 April to recognize global efforts to control malaria. The theme for 2016 was “End Malaria For Good”, which focused on malaria elimination. Following the great progress made under the Millennium Development Goals, it is important to continue building on this success as we transition into the Sustainable Development Goals [1] and the recently launched Global Technical Strategy for Malaria (GTS) [2]. The aim of the piece is to briefly reflect on WMD 2016 and consider a few key operational issues on malaria elimination that may lie ahead for the coming year.

Malaria situation in a clear area of Iran: an approach for the better understanding of the health service providers’ readiness and challenges for malaria elimination in clear areas

March 23, 2020 - 11:33 -- Open Access
Hosein Azizi, Elham Davtalab-Esmaeili, Mostafa Farahbakhsh, Maryam Zeinolabedini, Yagoub Mirzaei and Mohammad Mirzapour
Malaria Journal 2020 19:114, 18 March 2020

Malaria mortality and morbidity have decreased in recent years. Malaria elimination (ME) and effective efforts to achieve ME is one of the most important priorities for health systems in countries in the elimination phase. In very low transmission areas, the ME programme is faced with serious challenges. This study aimed to assess the trend while getting a better understanding of Health Service Providers’ (HSPs) readiness and challenges for ME in a clear area of Iran.

The prevalence of glucose-6-phosphate dehydrogenase deficiency in the Cape Verdean population in the context of malaria elimination

March 19, 2020 - 08:44 -- Open Access
DePina AJ, Pires CM, Andrade AJB, Dia AK, Moreira AL, Ferreira MCM, Correia AJ, Faye O, Seck I, Niang EHA
PLoS One. 2020 Mar 16; 15(3):e0229574

Cabo Verde aims to eliminate malaria by 2020. In the country, Plasmodium falciparum had been the main parasite responsible for indigenous cases and primaquine is the first line treatment of cases and for radical cure. However, the lack of knowledge of the national prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may be one of the constraints to the malaria elimination process. Hence, this first study determines the prevalence of G6PD deficiency (G6PDd) in the archipelago.

NOT Open Access | Tafenoquine: A step toward malaria elimination

February 24, 2020 - 14:18 -- NOT Open Access
Lu KY, Derbyshire ER
Biochemistry. 2020 Feb 19

There is a pressing need for compounds with broad-spectrum activity against malaria parasites at different life cycle stages to achieve malaria elimination. However, this goal cannot be accomplished without targeting the tenacious dormant liver stage hypnozoite that causes multiple relapses after the first episode of illness. In search for the magic bullet to radically cure Plasmodium vivax malaria, tafenoquine outperformed other candidate drugs and was approved by the US Food and Drug Administration in 2018. Tafenoquine is an 8-aminoquinoline that inhibits multiple life stages of different Plasmodium species.

Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination

February 17, 2020 - 14:54 -- Open Access
Ngassa Mbenda HG, Wang M, Guo J, Siddiqui FA, Hu Y, Yang Z, Kittichai V, Sattabongkot J, Cao Y, Jiang L, Cui L
Parasit Vectors. 2020 Feb 12;13(1):67

The malaria elimination plan of the Greater Mekong Subregion (GMS) is jeopardized by the increasing number of Plasmodium vivax infections and emergence of parasite strains with reduced susceptibility to the frontline drug treatment chloroquine/primaquine. This study aimed to determine the evolution of the P. vivax multidrug resistance 1 (Pvmdr1) gene in P. vivax parasites isolated from the China–Myanmar border area during the major phase of elimination.

Challenges in early phase of implementing the 1-3-7 surveillance and response approach in malaria elimination setting: A field study from Myanmar

February 14, 2020 - 16:46 -- Open Access
Aung PP, Thein ZW, Hein ZNM, Aung KT, Mon NO, Linn NYY, Thi A, Wai KT, Maung TM
Infect Dis Poverty. 2020 Feb 10;9(1):18

The National Plan for Malaria Elimination (NPME) in Myanmar (2016–2030) aims to eliminate indigenous Plasmodium falciparum malaria in six states/regions of low endemicity by 2020 and countrywide by 2030. To achieve this goal, in 2016 the National Malaria Control Program (NMCP) implemented the “1-3-7” surveillance and response strategy. This study aims to identify the barriers to successful implementation of the NPME which emerged during the early phase of the “1-3-7” approach deployment.

The resistome and genomic reconnaissance in the age of malaria elimination

January 15, 2020 - 09:06 -- Open Access
Kümpornsin K, Kochakarn T, Chookajorn T
Disease Models & Mechanisms, vol. 12 no. 12, dmm040717

Malaria is an infectious disease caused by parasitic protozoa in the Plasmodium genus. A complete understanding of the biology of these parasites is challenging in view of their need to switch between the vertebrate and insect hosts. The parasites are also capable of becoming highly motile and of remaining dormant for decades, depending on the stage of their life cycle.

Understanding challenges to malaria elimination in Nepal: a qualitative study with an embedded capacity-building exercise

December 30, 2019 - 14:32 -- Open Access
Shiva Raj Adhikari, Vishnu P. Sapkota, Arjun K. Thapa and Yubraj Acharya
Malaria Journal 2019 18:437, 21 December 2019

The Nepalese Government has made significant progress toward the elimination of malaria. However, given the surge in the prevalence of non-communicable diseases, such as diabetes and hypertension, and the localized nature of malaria prevalence, malaria elimination will remain a challenge. In the current study, the authors sought to understand local perceptions on threats to malaria elimination in three endemic districts.

The 2019 Isdell:Flowers Cross Border Malaria Initiative Round Table: community engagement in the context of malaria elimination

December 30, 2019 - 14:19 -- Open Access
Alexandra Gordon, Rebecca J. Vander Meulen and Alysse Maglior
Malaria Journal 2019 18:432, 19 December 2019

Government officials, representatives from malaria endemic communities, and nonprofit, academic, and private sector partners convened at the 2019 Isdell:Flowers Cross Border Malaria Initiative Round Table in Livingstone, Zambia from February 28–March 1, 2019 to discuss the necessity of community engagement and the involvement of those directly affected by malaria in malaria elimination efforts.

Assessing the role of the private sector in surveillance for malaria elimination in Haiti and the Dominican Republic: a qualitative study

December 10, 2019 - 10:58 -- Open Access
Sidibe A, Maglior A, Bennett A, et al.
Malar J. 2019 Dec 5; 18(1):408

Haiti and the Dominican Republic (DR) are targeting malaria elimination by 2022. The private health sector has been relatively unengaged in these efforts, even though most primary health care in Haiti is provided by non-state actors, and many people use traditional medicine. Data on private health sector participation in malaria elimination efforts are lacking, as are data on care-seeking behaviour of patients in the private health sector. This study sought to describe the role of private health sector providers, care-seeking behaviour of individuals at high risk of malaria, and possible means of engaging the private health sector in Hispaniola’s malaria elimination efforts.


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