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antimalarial

Not Open Access | What determines providers' stated preference for the treatment of uncomplicated malaria?

January 22, 2014 - 14:46 -- NOT Open Access
Author(s): 
Lindsay Mangham-Jefferies, Kara Hanson, Wilfred Mbacham, Obinna Onwujekwe, Virginia Wiseman
Reference: 
Social Science & Medicine, Volume 104, March 2014, Pages 98-106

518 providers working at non-profit health facilities and for-profit pharmacies and drug stores in Yaoundé and Bamenda in Cameroon and in Enugu State in Nigeria were surveyed between July and December 2009 to elicit the antimalarial they prefer to supply for uncomplicated malaria.

Not Open Access | Validation of ELISA for Quantitation of Artemisinin-Based Antimalarial Drugs

December 11, 2013 - 17:54 -- NOT Open Access
Author(s): 
Min Wang, Yongliang Cui, Guofa Zhou, Guiyun Yan, Liwang Cui and Baomin Wang
Reference: 
Am J Trop Med Hyg 2013 89:1122-1128

Our results showed that the icELISA has the potential to be improved for quality assurance of ARTs at the point of care in endemic settings.

Not Open Access | A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain

December 3, 2013 - 20:16 -- NOT Open Access
Author(s): 
Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Wilford Lie, Anthony C. Willis, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan
Reference: 
Journal of Ethnopharmacology, Volume 150, Issue 3, 12 December 2013, Pages 953-959
MalariaWorld

This study validated the traditional uses of the plant for the treatment of malaria and identified a new alkaloid, simplicifolianine as a potential antimalarial drug lead.

Not Open Access | Ethnobotanical survey on medicinal plants used by Guinean traditional healers in the treatment of malaria

December 3, 2013 - 20:08 -- NOT Open Access
Author(s): 
M.S. Traore, M.A. Baldé, A.M. Baldé, et al.
Reference: 
Journal of Ethnopharmacology, Volume 150, Issue 3, 12 December 2013, Pages 1145-1153
MalariaWorld

The objective of the present study was to collect and document information on herbal remedies traditionally used for the treatment of malaria in Guinea.

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Not Open Access | Antimalarial and safety evaluation of Pluchea lanceolata (DC.) Oliv. & Hiern: In-vitro and in-vivo study

September 25, 2013 - 07:18 -- NOT Open Access
Author(s): 
Shilpa Mohanty, Pooja Srivastava, Anil Kumar Maurya, Harveer Singh Cheema, Karuna Shanker, Sangeeta Dhawan, Mahendra Pandurang Darokar, Dnyaneshwar Umrao Bawankule
Reference: 
Journal of Ethnopharmacology, Volume 149, Issue 3, 7 October 2013, Pages 797-802
MalariaWorld

Present study further validates the ancient Indian traditional knowledge and use of Pluchea lanceolata as an antimalarial agent. Study confirms the suitability of Pluchea lanceolata as a candidate for further studies to obtain a prototype for antimalarial medicine.

Not Open Access | Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review

September 9, 2013 - 15:42 -- NOT Open Access
Author(s): 
Robert Duffy, Christine Wade, Raymond Chang
Reference: 
Drug Discovery Today, Volume 17, Issues 17–18, September 2012, Pages 942-953
MalariaWorld

Results are reported by source (plants, fungi, marine organisms and bacteria) and anticancer mechanism. In total, 14 out of 15 nature-derived antimalarials (93%) referenced by WHO as well as 146 of 235 antimalarial natural species (62%) from our defined MEDLINE search were reported as having anticancer activity.

Not Open Access | In vitro and in vivo antimalarial activity and cytotoxicity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii

September 2, 2013 - 19:12 -- NOT Open Access
Author(s): 
C.M. Kikueta, O.K. Kambu, A.P. Mbenza, S.T. Mavinga, B.M. Mbamu, P. Cos, L. Maes, S. Apers, L. Pieters, R.K. Cimanga
Reference: 
Journal of Ethnopharmacology, Volume 149, Issue 2, 16 September 2013, Pages 438-442
MalariaWorld

To evaluate the in vitro antiplasmodial activity and cytotoxicity, and the in vivo activity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii (De Wild) Staner (Menispermaceae), used in traditional medicine against malaria.

Not Open Access | Effects of the combined artesunate and mefloquine antimalarial drugs on rat embryos

August 14, 2013 - 04:46 -- NOT Open Access
Author(s): 
A.C. Boareto, J.C. Müller, E.L.B. Lourenço, N. Lombardi, A.C. Lourenço, I. Rabitto, R.N. de Morais, F.S. Rios, P.R. Dalsenter
Reference: 
Hum Exp Toxicol September 2013 vol. 32 no. 9 930-941
MalariaWorld

To evaluate the effects of isolated and combined artesunate (AS)/mefloquine (MQ) on embryo rats, pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9–11 post coitum (pc).

Not Open Access | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

July 18, 2013 - 17:37 -- NOT Open Access
Author(s): 
Carlos Barea, Adriana Pabón, Denis Castillo, Mirko Zimic, Miguel Quiliano, Silvia Galiano, Silvia Pérez-Silanes, Antonio Monge, Eric Deharo, Ignacio Aldana
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 15, 1 August 2011, Pages 4498-4502
MalariaWorld

The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found.

Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal

June 6, 2013 - 15:53 -- Open Access
Author(s): 
Magatte Ndiaye, Roger Tine, Babacar Faye, Jean Louis Ndiaye, Ami Colle Lo, Khadime Sylla, Annie Abiola, Yémou Dieng, Daouda Ndiaye, Rachel Hallett, Oumar Gaye and Michael Alifrangis
Reference: 
Am J Trop Med Hyg 2013 88:1124-1129
MalariaWorld

Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (N = 352) collected from children < 5 years were analyzed to determine the prevalence of SP resistance-related haplotypes by nested PCR followed by sequence-specific oligonucleotide probe-enzyme-linked immunosorbent assay.

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