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antimalarial

Not Open Access | Antimalarial and safety evaluation of Pluchea lanceolata (DC.) Oliv. & Hiern: In-vitro and in-vivo study

September 25, 2013 - 07:18 -- NOT Open Access
Author(s): 
Shilpa Mohanty, Pooja Srivastava, Anil Kumar Maurya, Harveer Singh Cheema, Karuna Shanker, Sangeeta Dhawan, Mahendra Pandurang Darokar, Dnyaneshwar Umrao Bawankule
Reference: 
Journal of Ethnopharmacology, Volume 149, Issue 3, 7 October 2013, Pages 797-802
MalariaWorld

Present study further validates the ancient Indian traditional knowledge and use of Pluchea lanceolata as an antimalarial agent. Study confirms the suitability of Pluchea lanceolata as a candidate for further studies to obtain a prototype for antimalarial medicine.

Not Open Access | Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review

September 9, 2013 - 15:42 -- NOT Open Access
Author(s): 
Robert Duffy, Christine Wade, Raymond Chang
Reference: 
Drug Discovery Today, Volume 17, Issues 17–18, September 2012, Pages 942-953
MalariaWorld

Results are reported by source (plants, fungi, marine organisms and bacteria) and anticancer mechanism. In total, 14 out of 15 nature-derived antimalarials (93%) referenced by WHO as well as 146 of 235 antimalarial natural species (62%) from our defined MEDLINE search were reported as having anticancer activity.

Not Open Access | In vitro and in vivo antimalarial activity and cytotoxicity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii

September 2, 2013 - 19:12 -- NOT Open Access
Author(s): 
C.M. Kikueta, O.K. Kambu, A.P. Mbenza, S.T. Mavinga, B.M. Mbamu, P. Cos, L. Maes, S. Apers, L. Pieters, R.K. Cimanga
Reference: 
Journal of Ethnopharmacology, Volume 149, Issue 2, 16 September 2013, Pages 438-442
MalariaWorld

To evaluate the in vitro antiplasmodial activity and cytotoxicity, and the in vivo activity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii (De Wild) Staner (Menispermaceae), used in traditional medicine against malaria.

Not Open Access | Effects of the combined artesunate and mefloquine antimalarial drugs on rat embryos

August 14, 2013 - 04:46 -- NOT Open Access
Author(s): 
A.C. Boareto, J.C. Müller, E.L.B. Lourenço, N. Lombardi, A.C. Lourenço, I. Rabitto, R.N. de Morais, F.S. Rios, P.R. Dalsenter
Reference: 
Hum Exp Toxicol September 2013 vol. 32 no. 9 930-941
MalariaWorld

To evaluate the effects of isolated and combined artesunate (AS)/mefloquine (MQ) on embryo rats, pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9–11 post coitum (pc).

Not Open Access | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

July 18, 2013 - 17:37 -- NOT Open Access
Author(s): 
Carlos Barea, Adriana Pabón, Denis Castillo, Mirko Zimic, Miguel Quiliano, Silvia Galiano, Silvia Pérez-Silanes, Antonio Monge, Eric Deharo, Ignacio Aldana
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 15, 1 August 2011, Pages 4498-4502
MalariaWorld

The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found.

Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal

June 6, 2013 - 15:53 -- Open Access
Author(s): 
Magatte Ndiaye, Roger Tine, Babacar Faye, Jean Louis Ndiaye, Ami Colle Lo, Khadime Sylla, Annie Abiola, Yémou Dieng, Daouda Ndiaye, Rachel Hallett, Oumar Gaye and Michael Alifrangis
Reference: 
Am J Trop Med Hyg 2013 88:1124-1129
MalariaWorld

Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (N = 352) collected from children < 5 years were analyzed to determine the prevalence of SP resistance-related haplotypes by nested PCR followed by sequence-specific oligonucleotide probe-enzyme-linked immunosorbent assay.

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Not Open Access | Role of Traditional Antimalarial Plants in the Battle Against the Global Malaria Burden

May 17, 2013 - 18:15 -- NOT Open Access
Author(s): 
Kaliyaperumal Karunamoorthi, Shanmugavelu Sabesan, Kaliyaperumal Jegajeevanram and Jayaraman Vijayalakshmi
Reference: 
Vector-Borne and Zoonotic Diseases
MalariaWorld

Although many believe that the use of medicinal plants that have folklore reputations for antimalarial properties is relatively safe, many herbs may be potentially toxic due to their intrinsic adverse side effects. Therefore, herbal-derived remedies require powerful and deep assessment of their pharmacological qualities to establish their mode of action, safety, quality, and efficacy. 

Predictive modeling of anti-malarial molecules inhibiting apicoplast formation

February 21, 2013 - 04:54 -- Open Access
Author(s): 
Salma Jamal, Vinita Periwal, Open Source Drug Discovery Consortium and Vinod Scaria
Reference: 
BMC Bioinformatics 2013, 14:55
MalariaWorld

In the present study, we have used high-throughput screen datasets for the discovery of apicoplast inhibitors of the malarial pathogen as assayed from the delayed death response.

NOT Open Access | Substantiation of the ethnopharmacological use of Conyza sumatrensis (Retz.) E.H.Walker in the treatment of malaria through in-vivo evaluation in Plasmodium berghei infected mice

January 8, 2013 - 12:54 -- NOT Open Access
Author(s): 
Pone Kamdem Boniface, Anirban Pal
Reference: 
Journal of Ethnopharmacology, Volume 145, Issue 1, 9 January 2013, Pages 373-377
MalariaWorld

Our study has tried to address this gap by authenticating its traditional use for the treatment of malaria.

Not Open Access | Oxidative stress in malaria

December 9, 2012 - 13:14 -- NOT Open Access
Author(s): 
Percário S, Moreira DR, Gomes BA, Ferreira ME, Gonçalves AC, Laurindo PS, Vilhena TC, Dolabela MF, Green MD.
Reference: 
Int J Mol Sci. 2012 Dec 3;13(12):16346-72
MalariaWorld

In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.

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