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antimalarial

NOT Open Access | Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues

April 27, 2015 - 13:07 -- NOT Open Access
Author(s): 
Ana Maria Faisca Phillips, Fatima Nogueira, Fernanda Murtinheira, Maria Teresa Barros
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 10, 15 May 2015, Pages 2112–2116

The continuous development of drug resistance by Plasmodium falciparum, the agent responsible for the most severe forms of malaria, creates the need for the development of novel drugs to fight this disease.

Antimalarial resistance: is vivax left behind?

September 23, 2014 - 17:08 -- Open Access
Author(s): 
The Lancet Infectious Diseases, Volume 14, Issue 10, October 2014, Pages 908-909
Reference: 
Frédéric Ariey, Richard E Paul

In addition to containing their high-quality analysis, their Article proposes a set of methods to explore resistance to antimalarial drugs in vivax malaria and highlights a surprising scarcity of data and methods available to work on P vivax.

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis

September 23, 2014 - 17:02 -- Open Access
Author(s): 
Ric N Price, Lorenz von Seidlein, Neena Valecha, Francois Nosten, J Kevin Baird, Nicholas J White
Reference: 
The Lancet Infectious Diseases, Volume 14, Issue 10, October 2014, Pages 982-991

We determined rates of chloroquine resistance according to P vivax malaria recurrence rates by day 28 whole-blood chloroquine concentrations at the time of recurrence and study enrolment criteria.

In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice

March 20, 2014 - 17:07 -- Open Access
Author(s): 
Laychiluh Bantie, Solomon Assefa, Tilahun Teklehaimanot and Ephrem Engidawork
Reference: 
BMC Complementary and Alternative Medicine 2014, 14:79

This study therefore aimed at investigating the in vivo antiplasmodial activity of 80% methanol extract and solvent fractions of the leaves of Croton macrostachyus H. in rodent model of malaria.

Not Open Access | 1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: Synthesis and antimalarial evaluation

February 5, 2014 - 02:28 -- NOT Open Access
Author(s): 
Raghu Raj, Jiri Gut, Philip J. Rosenthal, Vipan Kumar
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 24, Issue 3, 1 February 2014, Pages 756-759

A series of 1H-1,2,3-triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates have been synthesized and evaluated for their antimalarial activity against chloroquine-resistant W2 strain of Plasmodium falciparum.

Not Open Access | Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides

February 5, 2014 - 02:26 -- NOT Open Access
Author(s): 
Frans J. Smit, David D. N’Da
Reference: 
Bioorganic & Medicinal Chemistry, Volume 22, Issue 3, 1 February 2014, Pages 1128-1138

During this study, amide 15 was thus identified as the best drug-candidate to for further investigation as a potential drug in search for new, safe and effective antimalarial drugs.

Not Open Access | What determines providers' stated preference for the treatment of uncomplicated malaria?

January 22, 2014 - 14:46 -- NOT Open Access
Author(s): 
Lindsay Mangham-Jefferies, Kara Hanson, Wilfred Mbacham, Obinna Onwujekwe, Virginia Wiseman
Reference: 
Social Science & Medicine, Volume 104, March 2014, Pages 98-106

518 providers working at non-profit health facilities and for-profit pharmacies and drug stores in Yaoundé and Bamenda in Cameroon and in Enugu State in Nigeria were surveyed between July and December 2009 to elicit the antimalarial they prefer to supply for uncomplicated malaria.

Not Open Access | Validation of ELISA for Quantitation of Artemisinin-Based Antimalarial Drugs

December 11, 2013 - 17:54 -- NOT Open Access
Author(s): 
Min Wang, Yongliang Cui, Guofa Zhou, Guiyun Yan, Liwang Cui and Baomin Wang
Reference: 
Am J Trop Med Hyg 2013 89:1122-1128

Our results showed that the icELISA has the potential to be improved for quality assurance of ARTs at the point of care in endemic settings.

Not Open Access | A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain

December 3, 2013 - 20:16 -- NOT Open Access
Author(s): 
Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Wilford Lie, Anthony C. Willis, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan
Reference: 
Journal of Ethnopharmacology, Volume 150, Issue 3, 12 December 2013, Pages 953-959
MalariaWorld

This study validated the traditional uses of the plant for the treatment of malaria and identified a new alkaloid, simplicifolianine as a potential antimalarial drug lead.

Not Open Access | Ethnobotanical survey on medicinal plants used by Guinean traditional healers in the treatment of malaria

December 3, 2013 - 20:08 -- NOT Open Access
Author(s): 
M.S. Traore, M.A. Baldé, A.M. Baldé, et al.
Reference: 
Journal of Ethnopharmacology, Volume 150, Issue 3, 12 December 2013, Pages 1145-1153
MalariaWorld

The objective of the present study was to collect and document information on herbal remedies traditionally used for the treatment of malaria in Guinea.

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