The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10623 malaria professionals are enjoying the free benefits of MalariaWorld today

antimalarial

Not Open Access | Effects of the combined artesunate and mefloquine antimalarial drugs on rat embryos

August 14, 2013 - 04:46 -- NOT Open Access
Author(s): 
A.C. Boareto, J.C. Müller, E.L.B. Lourenço, N. Lombardi, A.C. Lourenço, I. Rabitto, R.N. de Morais, F.S. Rios, P.R. Dalsenter
Reference: 
Hum Exp Toxicol September 2013 vol. 32 no. 9 930-941
MalariaWorld

To evaluate the effects of isolated and combined artesunate (AS)/mefloquine (MQ) on embryo rats, pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9–11 post coitum (pc).

Not Open Access | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

July 18, 2013 - 17:37 -- NOT Open Access
Author(s): 
Carlos Barea, Adriana Pabón, Denis Castillo, Mirko Zimic, Miguel Quiliano, Silvia Galiano, Silvia Pérez-Silanes, Antonio Monge, Eric Deharo, Ignacio Aldana
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 15, 1 August 2011, Pages 4498-4502
MalariaWorld

The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found.

Selection of Antimalarial Drug Resistance after Intermittent Preventive Treatment of Infants and Children (IPTi/c) in Senegal

June 6, 2013 - 15:53 -- Open Access
Author(s): 
Magatte Ndiaye, Roger Tine, Babacar Faye, Jean Louis Ndiaye, Ami Colle Lo, Khadime Sylla, Annie Abiola, Yémou Dieng, Daouda Ndiaye, Rachel Hallett, Oumar Gaye and Michael Alifrangis
Reference: 
Am J Trop Med Hyg 2013 88:1124-1129
MalariaWorld

Our study investigated the possible impact of SP-IPT given to infants and children on the prevalence of SP-resistant haplotypes in the Plasmodium falciparum genes Pfdhfr and Pfdhps, comparing sites with and without IPTi/c. P. falciparum positive samples (N = 352) collected from children < 5 years were analyzed to determine the prevalence of SP resistance-related haplotypes by nested PCR followed by sequence-specific oligonucleotide probe-enzyme-linked immunosorbent assay.

Person: 
Country: 

Not Open Access | Role of Traditional Antimalarial Plants in the Battle Against the Global Malaria Burden

May 17, 2013 - 18:15 -- NOT Open Access
Author(s): 
Kaliyaperumal Karunamoorthi, Shanmugavelu Sabesan, Kaliyaperumal Jegajeevanram and Jayaraman Vijayalakshmi
Reference: 
Vector-Borne and Zoonotic Diseases
MalariaWorld

Although many believe that the use of medicinal plants that have folklore reputations for antimalarial properties is relatively safe, many herbs may be potentially toxic due to their intrinsic adverse side effects. Therefore, herbal-derived remedies require powerful and deep assessment of their pharmacological qualities to establish their mode of action, safety, quality, and efficacy. 

Predictive modeling of anti-malarial molecules inhibiting apicoplast formation

February 21, 2013 - 04:54 -- Open Access
Author(s): 
Salma Jamal, Vinita Periwal, Open Source Drug Discovery Consortium and Vinod Scaria
Reference: 
BMC Bioinformatics 2013, 14:55
MalariaWorld

In the present study, we have used high-throughput screen datasets for the discovery of apicoplast inhibitors of the malarial pathogen as assayed from the delayed death response.

NOT Open Access | Substantiation of the ethnopharmacological use of Conyza sumatrensis (Retz.) E.H.Walker in the treatment of malaria through in-vivo evaluation in Plasmodium berghei infected mice

January 8, 2013 - 12:54 -- NOT Open Access
Author(s): 
Pone Kamdem Boniface, Anirban Pal
Reference: 
Journal of Ethnopharmacology, Volume 145, Issue 1, 9 January 2013, Pages 373-377
MalariaWorld

Our study has tried to address this gap by authenticating its traditional use for the treatment of malaria.

Not Open Access | Oxidative stress in malaria

December 9, 2012 - 13:14 -- NOT Open Access
Author(s): 
Percário S, Moreira DR, Gomes BA, Ferreira ME, Gonçalves AC, Laurindo PS, Vilhena TC, Dolabela MF, Green MD.
Reference: 
Int J Mol Sci. 2012 Dec 3;13(12):16346-72
MalariaWorld

In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.

Not Open Access | A Plasmodium multi-domain protein possesses multiple inositol phosphate kinase activities

December 3, 2012 - 15:47 -- NOT Open Access
Author(s): 
Carina Stritzke, Marcus M. Nalaskowski, Werner Fanick, Hongying Lin, Georg W. Mayr
Reference: 
Molecular and Biochemical Parasitology, Volume 186, Issue 2, December 2012, Pages 134-138
MalariaWorld

To further investigate the InsPx metabolism in these parasites a Plasmodium protein possessing inositol phosphate kinase (IPK) activity was recombinantly expressed, purified and enzymatically characterized for the first time

In vitro antimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon

November 19, 2012 - 05:09 -- Open Access
Author(s): 
Zatra R, Lekana-douki JB, Lekoulou F, Bisvigou U, Ngoungou EB, Ndouo FS
Reference: 
BMC Infectious Diseases 2012, 12:307 (15 November 2012)
MalariaWorld

The aims of this study were to analyze the in vitro sensitivity of P. falciparum field isolates from Franceville, Gabon, to chloroquine (CQ), mefloquine (MF), dihydroartemisinine (DHA) and monodesethylamodiaquine (MDAQ), and to investigate polymorphisms associated with drug resistance.

Country: 

Guest Editorial: Don't fake it!

January 26, 2012 - 13:22 -- Bart G.J. Knols

This guest editorial was written by Dr. Lotte Van Dijk in The Netherlands.

 

Many of you will have come across counterfeit or substandard drugs in your careers and I’m sure many of you will understand my frustration. Therefore, I was really happy to see that the study on poor-quality anti-malarials by Dr Paul Newton and his team got the attention of the media. Even though their study was not large-scale and even though it cannot provide an accurate estimation of the prevalence of the fake anti-malarials all over Africa, it does provide an insight into the seriousness of the problem: it is severe!

Pages

Subscribe to RSS - antimalarial