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Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector, Anopheles gambiae

December 10, 2019 - 11:11 -- Open Access
Adolfi A, Poulton B, Anthousi A, Macilwee S, Ranson H, Lycett GJ
Proc Natl Acad Sci U S A. 2019 Dec 4. pii: 201914633

Resistance in Anopheles gambiae to members of all 4 major classes (pyrethroids, carbamates, organochlorines, and organophosphates) of public health insecticides limits effective control of malaria transmission in Africa. Increase in expression of detoxifying enzymes has been associated with insecticide resistance, but their direct functional validation in An. gambiae is still lacking.

First malaria vaccine rolled out in Africa - despite limited efficacy and nagging safety concerns

November 28, 2019 - 13:29 -- Malaria World

Science, Nov. 26, 2019: by Jop de Vrieze

MALAWI—In a small room at the Phalula Health Centre in southern Malawi's Balaka district, two young mothers are sitting on a wooden bench, each with a 5-month-old baby on their lap. Across from them, behind a desk, sits Alfred Kaponya, a community health worker. A colleague is busy preparing a vaccine, tapping the syringe to dislodge bubbles. Kaponya explains the procedure to the women, writes down the vaccines' serial numbers in the children's vaccination booklets, and copies them onto a spreadsheet in his binder.

Problem formulation for gene drive mosquitoes designed to reduce malaria transmission in Africa: results from four regional consultations 2016–2018

October 22, 2019 - 05:05 -- Open Access
John L. Teem, Aggrey Ambali, Barbara Glover, Jeremy Ouedraogo, Diran Makinde and Andrew Roberts
Malaria Journal 2019 18:347, 15 October 2019

Gene drive mosquitoes have been proposed as a possible means to reduce the transmission of malaria in Africa. Because this technology has no prior use-history at this time, environmental risk assessments for gene drive mosquitoes will benefit from problem formulation—an organized and ordered process to identify protection goals and potential pathways to harm to the environment, or animal or human health. Recognizing this need, the New Partnership for Africa’s Development (NEPAD), with support from African and international partners, organized four regional consultative workshops in Africa to initiate this process.


Malaria around large dams in Africa: effect of environmental and transmission endemicity factors

September 10, 2019 - 15:32 -- Open Access
Solomon Kibret, Jonathan Lautze, Matthew McCartney, Luxon Nhamo and Guiyun Yan
Malaria Journal 2019 18:303, 3 September 2019

The impact of large dams on malaria has received widespread attention. However, understanding how dam topography and transmission endemicity influence malaria incidences is limited.

Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa

September 10, 2019 - 15:31 -- Open Access
Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse
Malaria Journal 2019 18:268, 3 September 2019

Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions.

Deployment and utilization of next-generation sequencing of Plasmodium falciparum to guide anti-malarial drug policy decisions in sub-Saharan Africa: opportunities and challenges

September 10, 2019 - 15:29 -- Open Access
Deus S. Ishengoma, Queen Saidi, Carol H. Sibley, Cally Roper and Michael Alifrangis
Malaria Journal 2019 18:267, 3 September 2019

Parasite resistance against anti-malarial drugs is a major threat to the ongoing malaria control and elimination strategies.

Management of severe paediatric malaria in resource-limited settings

March 18, 2015 - 12:45 -- Open Access
Kathryn Maitland
BMC Medicine 2015, 13:42

This review highlights the spectrum of complications in African children with severe malaria, the therapeutic challenges of managing these in resource-poor settings and examines in-depth the results from clinical trials with a view to identifying the treatment priorities and a future research agenda.

Global malaria eradication and the importance of Plasmodium falciparum epidemiology in Africa

February 4, 2015 - 14:36 -- Open Access
Robert W Snow
BMC Medicine 2015, 13:23

This commentary highlights why the epidemiology of Plasmodium falciparum malaria in Africa should not be forgotten when planning an eradication strategy, and why forgetting Africa will, once again, be the single largest threat to any hope for global eradication.

Research: Suppression of malaria transmission and increases in economic productivity in African countries from 2007 to 2011

March 7, 2014 - 11:10 -- Ingeborg van Schayk
William R. Jobin
MWJ 2014, 5, 4

To test the assumption that reductions in malaria in Africa will increase economic productivity, a correlation-regression analysis was conducted to evaluate the impact ofexpenditures by the US President’s Malaria Initiative for Africa (PMI), and increases in the economic productivity of countries included in the PMI. For the 12 most representative countries the per capita expenditures for malaria suppression in the 2011 budget of the PMI were compared with observed increases in per capita economic productivity. The measure of economic productivity used was the per capita Gross Domestic Product (GDP) for the period 2007 to 2011. With a mean annual expenditure for suppressing malaria slightly above 1 US dollar per capita (range 0.44-3.40), there was a positive but weak correlation of higher expenditures with increased economic productivity. The correlation coefficient r was 0.5. The increase in per capita GDP in these countries over the 4-year period varied between 60 and 200 USD. The slope of the regression line and thus the ratio of benefits to cost from this programme varied slightly between ecologic zones, but the mean was 6.75 to 1. This meant that there was an increase in per capita GDP of $6.75 for every $1 invested per capita in suppressing malaria. The high benefits to cost ratio from the PMI makes suppression of malaria by methods used by the initiative potentially an attractive investment, at least for the near future while the biocides and drugs deployed are still effective.


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