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World Health Organization

Adoption of evidence-based global policies at the national level: intermittent preventive treatment for malaria in pregnancy and first trimester treatment in Kenya, Malawi, Mali and The Gambia

November 14, 2020 - 16:19 -- Open Access
Author(s): 
Webster J, Hoyt J, Hill J, et al.
Reference: 
Health Policy Plan. 2020 Nov 12:czaa132

In 2012, the World Health Organization (WHO) updated its policy on intermittent preventive treatment in pregnancy with sulphadoxine-pyrimethamine (IPTp-SP). A global recommendation to revise the WHO policy on the treatment of malaria in the first trimester is under review. We conducted a retrospective study of the national policy adoption process for revised IPTp-SP dosing in four sub-Saharan African countries.

Preventing the re-establishment of malaria in Sri Lanka amidst the COVID-19 pandemic

November 4, 2020 - 09:58 -- Open Access
Author(s): 
Prasad Ranaweera, Rajitha Wickremasinghe and Kamini Mendis
Reference: 
Malaria Journal 2020 19:386, 2 November 2020

The COVID-19 pandemic has had a considerable impact on other health programmes in countries, including on malaria, and is currently under much discussion. As many countries are accelerating efforts to eliminate malaria or to prevent the re-establishment of malaria from recently eliminated countries, the COVID-19 pandemic has the potential to cause major interruptions to ongoing anti-malaria operations and risk jeopardizing the gains that have been made so far.

House modifications for preventing malaria

October 20, 2020 - 16:15 -- Open Access
Author(s): 
Furnival-Adams J, Olanga EA, Napier M, Garner P
Reference: 
Cochrane Database Syst Rev. 2020 Oct 15;10:CD013398

Despite being preventable, malaria remains an important public health problem. The World Health Organization (WHO) reports that overall progress in malaria control has plateaued for the first time since the turn of the century. Researchers and policymakers are therefore exploring alternative and supplementary malaria vector control tools. Research in 1900 indicated that modification of houses may be effective in reducing malaria: this is now being revisited, with new research now examining blocking house mosquito entry points or modifying house construction materials to reduce exposure of inhabitants to infectious bites.

Targeted Covalent Inhibitors for the Treatment of Malaria

October 20, 2020 - 15:59 -- Open Access
Author(s): 
Kulkarni S, Urbahns K, Spangenberg T
Reference: 
ACS Infect Dis. 2020 Oct 15

Malaria is a vector-borne disease caused by protozoan parasites of the genus Plasmodium. According to the World Health Organization, it is one of the most serious infectious diseases threatening more than 3 billion people worldwide. In recent years, targeted covalent inhibitors (TCIs) have gained a lot of attention and several TCI-based drugs have been approved across different therapeutic areas.

Generation of a malaria negative Ugandan birth weight standard for the diagnosis of small for gestational age

October 6, 2020 - 12:37 -- Open Access
Author(s): 
Zakama AK, Weekes T, Kajubi R, Kakuru A, Ategeka J, Kamya M, Muhindo MK, Havlir D, Jagannathan P, Dorsey G, Gaw SL
Reference: 
PLoS One. 2020 Oct 2;15(10):e0240157

Placental malaria is a known risk factor for small for gestational age (SGA) neonates. However, currently utilized international and African birthweight standards have not controlled for placental malaria and/or lack obstetrical ultrasound dating. We developed a neonatal birthweight standard based on obstetrically dated pregnancies that excluded individuals with clinical malaria, asymptomatic parasitemia, and placental malaria infection. We hypothesized that current curves underestimate true ideal birthweight and the prevalence of SGA.

A new malaria vector in Africa: Predicting the expansion range of Anopheles stephensi and identifying the urban populations at risk

September 16, 2020 - 13:01 -- Open Access
Author(s): 
Sinka ME, Pironon S, Massey NC, Longbottom J, Hemingway J, Moyes CL, Willis KJ
Reference: 
Natl Acad Sci U S A. 2020 Sep 14:202003976.

In 2012, an unusual outbreak of urban malaria was reported from Djibouti City in the Horn of Africa and increasingly severe outbreaks have been reported annually ever since. Subsequent investigations discovered the presence of an Asian mosquito species; Anopheles stephensi, a species known to thrive in urban environments. Since that first report, An. stephensi has been identified in Ethiopia and Sudan, and this worrying development has prompted the World Health Organization (WHO) to publish a vector alert calling for active mosquito surveillance in the region.

Individual, community and region level predictors of insecticide-treated net use among women in Uganda: a multilevel analysis

September 16, 2020 - 12:59 -- Open Access
Author(s): 
Edward Kwabena Ameyaw, Yusuf Olushola Kareem and Sanni Yaya
Reference: 
Malaria Journal 2020 19:337, 16 September 2020

Use of insecticide-treated net (ITN) has been identified by the World Health Organization as an effective approach for malaria prevention. The government of Uganda has instituted measures to enhance ITN supply over the past decade, however, the country ranks third towards the global malaria burden. As a result, this study investigated how individual, community and region level factors affect ITN use among women of reproductive age in Uganda.

NOT Open Access | Malaria fighters' latest chemical weapon may not last long

September 8, 2020 - 11:56 -- NOT Open Access
Author(s): 
Makoni M
Reference: 
Science. 2020 Sep 4;369(6508):1153

Two years ago, the World Health Organization (WHO) gave the green light for clothianidin, long used to kill crop pests, to be added to the current mainstays of indoor mosquito control, which are losing their effectiveness as the insects develop resistance.

Impact of Hydroxychloroquine/Chloroquine in COVID-19 Therapy: Two Sides of the Coin

September 8, 2020 - 11:36 -- Open Access
Author(s): 
Fatima U, Rizvi SSA, Fatima S, Hassan MI
Reference: 
J Interferon Cytokine Res. 2020 Sep 1

Coronavirus disease 2019 (COVID-19), which is caused by a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has recently emerged as a global health threat. To address this health emergency, various therapeutic approaches are currently under investigation. There is limited evidence on the effectiveness of hydroxychloroquine (HCQ) and chloroquine (CQ) as COVID-19 therapies, and thus World Health Organization (WHO) mentioned that "Current data shows that this drug does not reduce deaths among hospitalized COVID-19 patients, nor help people with mild or moderate disease."

NOT Open Access | A Cluster of Cryptic Plasmodium falciparum Malaria in African Migrants in Southern Italy, October 2017

August 25, 2020 - 15:22 -- NOT Open Access
Author(s): 
Brindicci G, Santoro CR, Loconsole D, Martinelli D, Prato R, Lonero G, Loperfido P, Buccoliero GB, Chironna M
Reference: 
Vector Borne Zoonotic Dis. 2020 Aug 20

Italy was declared malaria free by the World Health Organization in 1970. Despite this, nonimport malaria cases are on the increase in Italy and throughout the Mediterranean area. In Italy, in the period between 2011 and 2015, seven cases of locally acquired malaria have been reported, including one introduced case of Plasmodium vivax; moreover, the last certain case of introduced malaria (by P. vivax) has been reported in Tuscany in 1997. No case of introduced malaria from Plasmodium falciparum has been reported in Italy since 1970.

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