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Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria

July 21, 2020 - 15:17 -- Open Access
Dos-Santos JCK, Silva-Filho JL, Costa FTM, et al.
PLoS Negl Trop Dis 14(7): e0007656

Platelets drive endothelial cell activation in many diseases. However, if this occurs in Plasmodium vivax malaria is unclear. As platelets have been reported to be activated and to play a role in inflammatory response during malaria, we hypothesized that this would correlate with endothelial alterations during acute illness. We performed platelet flow cytometry of PAC-1 and P-selectin.

Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections

July 21, 2020 - 15:15 -- Open Access
Rivera-Correa J, Yasnot-Acosta MF, Tovar NC, Velasco-Pareja MC, Easton A, Rodriguez A
PLoS Negl Trop Dis 14(7): e0008466

Malaria caused by Plasmodium vivax is a highly prevalent infection world-wide, that was previously considered mild, but complications such as anemia have been highly reported in the past years. In mice models of malaria, anti-phosphatidylserine (anti-PS) autoantibodies, produced by atypical B-cells, bind to uninfected erythrocytes and contribute to anemia. In human patients with P. falciparum malaria, the levels of anti-PS, atypical B-cells and anemia are strongly correlated to each other.

NOT Open Access | Efficacy and Safety of a Naphthoquine-Azithromycin Co-Formulation for Malaria Prophylaxis in Southeast Asia: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial

July 21, 2020 - 15:13 -- NOT Open Access
Yang H, Wang J, Cui L, et al.
Clin Infect Dis. 2020 Jul 20:ciaa1018

A prophylactic antimalarial drug that is both effective for protection and improves compliance is in high demand.

A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naïve Adults

July 21, 2020 - 15:07 -- Open Access
Moon JE, Ockenhouse C, Ofori-Anyinam O, et al.
Infect Dis. 2020 Jul 20:jiaa421

A previous RTS,S/AS01B vaccine challenge trial demonstrated a three-dose (0,1,7-month [M]) regimen with a fractional third dose can produce high vaccine efficacy (VE) in adults challenged three weeks post-vaccination. This study explored VE of different delayed fractional dose-regimens of adult and pediatric RTS,S/AS01-formulations.

Decreased bioefficacy of long-lasting insecticidal nets and the resurgence of malaria in Papua New Guinea

July 21, 2020 - 15:04 -- Open Access
Vinit R, Timinao L, Karl S, et al.
Nat Commun. 2020 Jul 20;11(1):3646

Papua New Guinea (PNG) has the highest malaria transmission outside of Africa. Long-lasting insecticidal nets (LLINs) are believed to have helped to reduce average malaria prevalence in PNG from 16% in 2008 to 1% in 2014. Since 2015 malaria in PNG has resurged significantly.

Insights in chloroquine action: perspectives and implications in Malaria and COVID-19

July 21, 2020 - 12:08 -- Open Access
Pillat MM, Krüger A, Guimarães LMF, Lameu C, de Souza EE, Wrenger C, Ulrich H
Cytometry A. 2020 Jul 19

Malaria is a threat to human mankind and kills about half a million people every year. On the other hand, COVID‐19 resulted in several hundred thousand deaths since December 2019 and remains without an efficient and safe treatment. The antimalarials chloroquine (CQ) and its analogue, hydroxychloroquine (HCQ), have been tested for COVID‐19 treatment, and several conflicting evidence has been obtained.

NOT Open Access | The changing risk patterns of Plasmodium vivax malaria in Greece due to climate change

July 21, 2020 - 12:05 -- NOT Open Access
Trájer AJ
Int J Environ Health Res. 2020 Jul 20:1-26

It has great importance to study the potential effects of climate change on Plasmodium vivax malaria in Greece because the country can be the origin of the spread of vivax malaria to the northern areas. The potential lengths of the transmission seasons of Plasmodium vivax malaria were forecasted for 2041–2060 and 2061–2080 and were combined.

NOT Open Access | Chemical profiling of the human skin surface for malaria vector control via a non-invasive sorptive sampler with GC×GC-TOFMS

July 21, 2020 - 12:03 -- NOT Open Access
Wooding M, Rohwer ER, Naudé Y
Anal Bioanal Chem. 2020 Jul 18

Volatile organic compounds (VOCs) and semi-VOCs detected on the human skin surface are of great interest to researchers in the fields of metabolomics, diagnostics, and skin microbiota and in the study of anthropophilic vector mosquitoes. Mosquitoes use chemical cues to find their host, and humans can be ranked for attractiveness to mosquitoes based on their skin chemical profile.

PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum

July 20, 2020 - 16:08 -- Open Access
Hitz E, Balestra AC, Brochet M, Voss TS
Sci Rep. 2020 Jul 17;10(1):11930

In malaria parasites, male gametogenesis is a proliferative stage essential for parasite transmission to the mosquito vector. It is a rapid process involving three rounds of genome replication alternating with closed endomitoses, and assembly of axonemes to produce eight flagellated motile microgametes. Studies in Plasmodium berghei have highlighted tight regulation of gametogenesis by a network of kinases.

Inversion Genotyping in the Anopheles gambiae Complex Using High-Throughput Array and Sequencing Platforms

July 20, 2020 - 16:05 -- Open Access
Love RR, Pombi M, Guelbeogo MW, Campbell NR, Stephens MT, Dabire RK, Costantini C, Torre AD, Besansky NJ
G3 (Bethesda). 2020 Jul 17:g3.401418.2020.

Chromosomal inversion polymorphisms have special importance in the Anopheles gambiae complex of malaria vector mosquitoes, due to their role in local adaptation and range expansion. The study of inversions in natural populations is reliant on polytene chromosome analysis by expert cytogeneticists, a process that is limited by the rarity of trained specialists, low throughput, and restrictive sampling requirements.


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