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Role of secondary level laboratories in strengthening quality at primary level health facilities’ laboratories: an innovative approach to ensure accurate HIV, tuberculosis, and malaria test results in resource-limited settings

December 11, 2012 - 07:12 -- Open Access
Author(s): 
Tsegahun Manyazewal, Antonio D. Paterniti, Robert R. Redfield, Francesco Marinucci
Reference: 
Diagnostic Microbiology and Infectious Disease, Volume 75, Issue 1, January 2013, Pages 55–59
MalariaWorld

Providing regular external quality assessment of primary level laboratories and timely feedback is crucial to ensure the reliability of testing capacity of the whole laboratory network.

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Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context

December 10, 2012 - 09:04 -- Open Access
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Author(s): 
Castellanos ME, Bardají A, Menegon M, Mayor A, Desai M, Severini C, Menéndez C, Padilla N
Reference: 
Malaria Journal 2012, 11:411 (8 December 2012)
MalariaWorld

This is a report of the first Plasmodium vivax congenital malaria case in Guatemala and the first case in Latin America with genotypical, histological and clinical characterization.

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Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi

December 10, 2012 - 09:01 -- Open Access
Author(s): 
Spence PJ, Jarra W, Lévy P, Nahrendorf W, Langhorne J
Reference: 
Malaria Journal 2012, 11:407 (6 December 2012)
MalariaWorld

This protocol was utilized for mosquito transmission of genetically distinct P. c. chabaudi isolates, highlighting differential parasite virulence within the mosquito vector and the spectrum of host  susceptibility to infection initiated via the natural route, mosquito bite.

Reduction of multiplicity of infections but no change in msp2 genetic diversity in Plasmodium falciparum isolates from Congolese children after introduction of artemisinin-combination therapy

December 10, 2012 - 08:55 -- Open Access
Author(s): 
Ibara-Okabande R, Koukouikila-Koussounda F, Ndounga M, Vouvoungui J, Malonga V, Casimiro P, Ibara J, Sidibe A, Ntoumi F
Reference: 
Malaria Journal 2012, 11:410 (7 December 2012)
MalariaWorld

This study shows that the introduction of ACT in the Republic of Congo has reduced the MOI but not the genetic diversity of P. falciparum isolates from children living in Southern districts of Brazzaville.

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IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with plasmodium vivax malaria in Brazil

December 10, 2012 - 08:50 -- Open Access
Author(s): 
Sortica VA, Cunha MG, Ohnishi MD, Souza JM, Ribeiro-dos-Santos ÂK, Santos NP, Callegari-Jacques SM, Santos SE, Hutz MH
Reference: 
Malaria Journal 2012, 11:409 (7 December 2012)
MalariaWorld

Plasmodium vivax malaria pathophysiology is still poorly understood.

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Application of loop-mediated isothermal amplification for malaria diagnosis during a follow-up study in Sao Tome

December 10, 2012 - 08:41 -- Open Access
Author(s): 
Lee P, Ji D, Liu C, Rampao HS, do Rosario VE, Lin I, Shaio M
Reference: 
Malaria Journal 2012, 11:408 (6 December 2012)
MalariaWorld

HRP-2-RDTs have similar sensitivity as microscopy but less specificity. However, as compared to nested PCR, the poor sensitivity of HRP-2-RDTs indicates that low parasitaemia may not be detected after treatment, as well as the low specificity of HRP-2-RDTs indicates it cannot be applied for treatment follow-up.

Malaria rapid diagnostic test transport and storage conditions in Burkina Faso, Senegal, Ethiopia and the Philippines

December 10, 2012 - 08:38 -- Open Access
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Author(s): 
Albertini A, Lee E, Coulibaly SO, Sleshi M, Faye B, Mationg ML, Ouedraogo K, Tsadik AG, Feleke SM, Diallo I, Gaye O, Luchavez J, Bennett J, Bell D
Reference: 
Malaria Journal 2012, 11:406 (6 December 2012)
MalariaWorld

Malaria RDTs were regularly exposed to temperatures above recommended limits for many commercially-available RDTs and other medical commodities such as drugs, but rarely exceeded the recommended storage limits for particular products in use in these countries.

Medical Treatment: 

Not Open Access | Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model

December 10, 2012 - 06:25 -- NOT Open Access
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Author(s): 
Yiwu Yan, Zhen Zou, Yang Sun, Xiao Li, Kai-Feng Xu, Yuquan Wei, Ningyi Jin and Chengyu Jiang
Reference: 
Cell Research , (4 December 2012)
MalariaWorld

The recent controversial studies of man-made avian flu viruses caused a media storm, and brought new concerns to the potential of an avian influenza H5N1 virus pandemic, which has been pending since 19971,2.

Factors determining the occurrence of submicroscopic malaria infections and their relevance for control

December 10, 2012 - 06:18 -- Open Access
Author(s): 
Lucy C. Okell, Teun Bousema, Jamie T. Griffin, André Lin Ouédraogo, Azra C. Ghani, Chris J. Drakeley
Reference: 
Nature Communications Volume: 3,Article number:1237
MalariaWorld

Here we analyse a series of data sets to characterize the distribution and epidemiological factors associated with low-density, submicroscopic infections. We show that submicroscopic parasite carriage is common in adults, in low-endemic settings and in chronic infections.

Decision-making on malaria vaccine introduction: the role of cost–effectiveness analyses

December 10, 2012 - 06:13 -- Open Access
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Author(s): 
Vasee S Moorthy, Raymond Hutubessy, Robert D Newman, Joachim Hombach
Reference: 
Bull World Health Organ vol.90 no.11 Genebra Nov. 2012
MalariaWorld

This article summarizes critical parameters driving malaria vaccine cost–effectiveness predictions and discusses major uncertainties that remain in the cost–effectiveness modelling arena. It also highlights the need for ongoing work by modelling groups to further refine cost–effectiveness predictions

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