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Randomized Controlled Trial of RTS,S/AS02D and RTS,S/AS01E Malaria Candidate Vaccines Given According to Different Schedules in Ghanaian Children

November 10, 2009 - 13:46 -- Ingeborg van Schayk
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Author(s): 
Owusu-Agyei S, Ansong D, Asante K, Kwarteng Owusu S, Owusu R, et al.
Reference: 
PLoS ONE 4(10): e7302

Both candidate malaria vaccines were well tolerated. Anti-circumsporozoite responses were greater with RTS,S/AS01E than RTS,S/AS02D and when 3 rather than 2 doses were given. This study supports the selection of RTS,S/AS01E and a 3 dose schedule for further development in children and infants.

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Safety and Immunogenicity of the Malaria Vaccine Candidate MSP3 Long Synthetic Peptide in 12–24 Months-Old Burkinabe Children

November 10, 2009 - 13:33 -- Ingeborg van Schayk
Author(s): 
Sirima SB, Tiono AB, Ouédraogo A, Diarra A, Ouédraogo AL, et al.
Reference: 
PLoS ONE 4(10): e7549

Our results support the promise of MSP3-LSP as a malaria vaccine candidate, both in terms of tolerability and of immunogenicity. Further assessment of the efficacy of this vaccine is recommended.

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A Randomized Trial Assessing the Safety and Immunogenicity of AS01 and AS02 Adjuvanted RTS,S Malaria Vaccine Candidates in Children in Gabon

November 10, 2009 - 13:26 -- Ingeborg van Schayk
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Author(s): 
Lell B, Agnandji S, von Glasenapp I, Haertle S, Oyakhiromen S, et al.
Reference: 
PLoS ONE 4(10): e7611

RTS,S/AS01E proved similarly as well tolerated and immunogenic as RTS,S/AS02D, completing an essential step in the age de-escalation process within the RTS,S clinical development plan.

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Combining Fungal Biopesticides and Insecticide-Treated Bednets to Enhance Malaria Control

November 10, 2009 - 13:15 -- Ingeborg van Schayk
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Author(s): 
Hancock PA
Reference: 
PLoS Comput Biol 5(10): e1000525

In developing strategies to control malaria vectors, there is increased interest in biological methods that do not cause instant vector mortality, but have sublethal and lethal effects at different ages and stages in the mosquito life cycle. By incorporating biological mechanisms relevant to vectorial capacity, continuous-time vector population models can increase their applicability to integrated vector management.

 

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Antimicrobial Agents: Progress in the development of piperaquine combinations for the treatment of malaria

October 31, 2009 - 10:33 -- Ingeborg van Schayk
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Author(s): 
D'Alessandro, Umberto
Reference: 
Current Opinion in Infectious Diseases. 22(6):588-592, December 2009

The dosage recommended for children may need to be reviewed and the usefulness of the coadministration with food should be determined. Establishing safety and efficacy of this treatment in pregnancy remains a priority.

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Distribution and larval habitat characterization of Anopheles moucheti, Anopheles nili, and other malaria vectors in river networks of southern Cameroon

October 31, 2009 - 09:19 -- Ingeborg van Schayk
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Author(s): 
Christophe Antonio-Nkondjio, Cyrille Ndo, Carlo Costantini, Parfait Awono-Ambene, Didier Fontenille, Frédéric Simard
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 270-276, doi:10.1016/j.actatropica.2009.08.009

Despite their importance as malaria vectors, little is known of the bionomic of Anopheles nili and Anopheles moucheti. Larval collections from 24 sites situated along the dense hydrographic network of south Cameroon were examined to assess key ecological factors associated with these mosquitoes distribution in river networks.

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Identification of a vaccine candidate antigen, PfMAg-1, from Plasmodium falciparum with monoclonal antibody M26-32

October 29, 2009 - 14:09 -- Ingeborg van Schayk
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Author(s): 
Yu-Hui Gao, Hui-Liang Li, Yan Lu, Fang-Ming Gao, Ya-Hui Lin, Hong-Chang Zhou, Lian-Hui Zhang & Heng Wang
Reference: 
Parasitology Research, Volume 105, Number 6 / November, 2009 : 1723-1732, DOI 10.1007/s00436-009-1617-4

Monoclonal antibody M26-32 has been shown to strongly inhibit the growth of Plasmodium falciparum in vitro. To identify the target antigen of M26-32, a P. falciparum Dd2 asexual stage cDNA expression library was screened with this antibody, and a full open reading frame cDNA was obtained.

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The malaria candidate vaccine liver stage antigen-3 is highly conserved in Plasmodium falciparum isolates from diverse geographical areas

October 29, 2009 - 12:53 -- Ingeborg van Schayk
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Author(s): 
Eric Prieur, Pierre Druilhe
Reference: 
Malaria Journal 2009, 8:247 (29 October 2009)

The paper compares the sequences of LSA-3 from four geographical areas and found LSA-3 to be a highly conserved antigen. This finding further supports the usefulness of LSA-3 as a pre-erythrocytic stage vaccine candidate.

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Assessing the burden of pregnancy-associated malaria under changing transmission settings

October 29, 2009 - 12:47 -- Ingeborg van Schayk
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Author(s): 
Mario Recker, Menno J Bouma, Paul Bamford, Sunetra Gupta, Andy P Dobson
Reference: 
Malaria Journal 2009, 8:245 (28 October 2009)

The clinical presentation of pregnancy-associated malaria depends crucially on the particular epidemiological settings. By re-examining historical data, and the use of a simple mathematical model, it is demonstrated how excess female mortality can be used to evaluate the burden of pregnancy-associated malaria.

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Comparison of different methods for delayed post-mortem diagnosis of falciparum malaria

October 29, 2009 - 12:43 -- Ingeborg van Schayk
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Author(s): 
Nicole Berens-Riha, Inga Sinicina, Erna Fleischmann, Thomas Loscher
Reference: 
Malaria Journal 2009, 8:244 (28 October 2009)

An interesting paper which addresses the issue of delayed post-mortem diagnosis of P. falciparum with ICT tests.

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