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Mass drug administration can be a valuable addition to the malaria elimination toolbox

August 27, 2019 - 21:50 -- Open Access
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Author(s): 
Thomas P. Eisele
Reference: 
Malaria Journal 2019 18:281, 22 August 2019

The Global Technical Strategy 2016–2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030.

Mass drug administration should be implemented as a tool to accelerate elimination: against

August 27, 2019 - 21:44 -- Open Access
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Author(s): 
Kamini Mendis
Reference: 
Malaria Journal 2019 18:279, 22 August 2019

In most malaria situations, mass drug administration (MDA) will result in a rapid reduction in the incidence and prevalence of malaria in the target population.

Determinants of long-lasting insecticidal net ownership and utilization in malaria transmission regions: evidence from Zimbabwe Demographic and Health Surveys

August 27, 2019 - 21:42 -- Open Access
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Author(s): 
Oscar Tapera
Reference: 
Malaria Journal 2019 18:278, 20 August 2019

Long-lasting insecticidal nets (LLINs) were first introduced in 2010 as a vector control intervention, to complement indoor residual spraying, to reduce malaria transmission in Zimbabwe. The objective of this study was to investigate factors that were associated with LLIN ownership and utilization among households in malaria transmission regions of Zimbabwe.

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Efficacy and safety of dihydroartemisinin–piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial

August 27, 2019 - 21:39 -- Open Access
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Author(s): 
Esperança Sevene, Clifford G. Banda, Victor Mwapasa, et al.
Reference: 
Malaria Journal 2019 18:277, 20 August 2019

HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efficacy and safety has not been evaluated in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events were assessed in HIV-infected individuals on non-nucleoside reverse transcriptase inhibitor-based ART (efavirenz and nevirapine) with uncomplicated P. falciparum malaria treated with dihydroartemisinin–piperaquine.

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Molecular detection of drug resistant malaria in Southern Thailand

August 19, 2019 - 17:40 -- Open Access
Author(s): 
Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen and Rogan Lee
Reference: 
Malaria Journal 2019 18:275, 15 August 2019

Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia. Plasmodium vivax first-line treatment drug is chloroquine together with primaquine, and the first-line treatment for P. falciparum malaria is artemisinin in combination with a partner drug. Plasmodium vivax and P. falciparum parasites resistant to their respective first-line therapies are now found within Southeast Asia. The resistance perimeters may include high transmission regions of Southern Thailand which are underrepresented in surveillance efforts.

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Bed net care practices and associated factors in western Kenya

August 19, 2019 - 17:33 -- Open Access
Author(s): 
Ellen M. Santos, Jenna E. Coalson, Elizabeth T. Jacobs, Yann C. Klimentidis, Stephen Munga, Maurice Agawo, Elizabeth Anderson, Nancy Stroupe and Kacey C. Ernst
Reference: 
Malaria Journal 2019 18:274, 14 August 2019

Insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are effective for malaria prevention and are designed to provide nearly 5 years of mosquito protection. However, many ITNs and LLINs become damaged and ineffective for mosquito bite prevention within 1 to 2 years in field conditions. Non-adherence to recommended bed net care and repair practices may partially explain this shortened net longevity.

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Larviciding to prevent malaria transmission

August 19, 2019 - 13:51 -- Open Access
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Author(s): 
Leslie Choi, Silas Majambere, Anne L Wilson
Reference: 
Cochrane Systematic Review - Intervention Version published: 14 August 2019

Larviciding refers to the regular application of chemical or microbial insecticides to water bodies or water containers to kill the aquatic immature forms of the mosquito (the larvae and pupae).

Knowledge, attitude and practice towards malaria among symptomatic patients attending Tumbi Referral Hospital: A cross-sectional study

August 13, 2019 - 15:53 -- Open Access
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Author(s): 
David Zadock Munisi, Azan A. Nyundo, Bonaventura C. Mpondo
Reference: 
PLoS ONE 14(8): e0220501

Despite significant improvement in prevention and control over the past decades malaria remains a significant public health concern in Tanzania with 93% of the population being at risk. To prevent malaria infection and promote malaria free zones, understanding the community’s knowledge, attitudes, and practices toward malaria control are essential. This study therefore aimed at determining the levels of understanding, and attitudes, as well as socio-cultural aspects of malaria prevention and treatment-seeking behaviours among suspected malaria patients.

Implementing population-based mass drug administration for malaria: experience from a high transmission setting in North Eastern Uganda

August 13, 2019 - 15:41 -- Open Access
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Author(s): 
Ronald Mulebeke, Humphrey Wanzira, Fred Bukenya, Thomas Eganyu, Kathryn Collborn, Richard Elliot, Jean-Pierre Van Geertruyden, Dorothy Echodu and Adoke Yeka
Reference: 
Malaria Journal 2019 18:271, 9 August 2019

Mass drug administration (MDA) is a suggested mean to accelerate efforts towards elimination and attainment of malaria-free status. There is limited evidence of suitable methods of implementing MDA programme to achieve a high coverage and compliance in low-income countries. The objective of this paper is to assess the impact of this MDA delivery strategy while using coverage measured as effective population in the community and population available.

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Genome annotation improvements from cross-phyla proteogenomics and time-of-day differences in malaria mosquito proteins using untargeted quantitative proteomics

August 9, 2019 - 15:17 -- Open Access
Author(s): 
Lisa Imrie, Thierry Le Bihan, Áine O'Toole, Paul V. Hickner, W. Augustine Dunn, Benjamin Weise, Samuel S. C. Rund
Reference: 
PLoS ONE 14(7): e0220225

The malaria mosquito, Anopheles stephensi, and other mosquitoes modulate their biology to match the time-of-day.

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