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Not Open Access | Asymptomatic malaria in the clinical and public health context

December 2, 2019 - 17:45 -- NOT Open Access
Author(s): 
Cheaveau J, Mogollon DC, Mohon MAN, Golassa L, Yewhalaw D, Pillai DR
Reference: 
Expert Rev Anti Infect Ther. 2019 Nov 21:1-14.

Historically, the global community has focused on the control of symptomatic malaria. However, interest in asymptomatic malaria has been growing, particularly in the context of malaria elimination.

NOT Open Access |Recent advances in transmission-blocking drugs for malaria elimination

December 2, 2019 - 15:10 -- NOT Open Access
Author(s): 
Wadi I, Nath M, Anvikar AR, Singh P, Sinha A.
Reference: 
Future Med Chem. 2019 Nov 29.

The scientific community worldwide has realized that malaria elimination will not be possible without development of safe and effective transmission-blocking interventions. Primaquine, the only WHO recommended transmission-blocking drug, is not extensively utilized because of the toxicity issues in G6PD deficient individuals.

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

December 2, 2019 - 15:08 -- Open Access
Author(s): 
Koch M, Cegla J, Jones B, Lu Y, Mallat Z, Blagborough AM, Angrisano F, Baum J.
Reference: 
Malaria Journal volume 18, 381 (2019)

Malaria disease commences when blood-stage parasites, called merozoites, invade human erythrocytes. Whilst the process of invasion is traditionally seen as being entirely merozoite-driven, emerging data suggests erythrocyte biophysical properties markedly influence invasion. Cholesterol is a major determinant of cell membrane biophysical properties demanding its interrogation as a potential mediator of resistance to merozoite invasion of the erythrocyte.

NOT Open Access | Vectorial Transmission of Malaria in Major Districts of Côte d'Ivoire

December 2, 2019 - 15:02 -- NOT Open Access
Author(s): 
Assouho KF, Adja AM, Yapi A, et al.
Reference: 
Journal of Medical Entomology tjz207, 2019 Nov 30

To better understand the influence of periodic mass distribution of Long-Lasting Insecticidal Nets (LLINs) on malaria transmission, a 1-yr entomological survey was conducted in three major districts of Côte d’Ivoire. Mosquitoes were sampled by Human Landing Catches (HLC) in urban and rural areas of San Pedro and Abidjan (coastal), and in Yamoussoukro (central). Mosquitoes were identified morphologically and by molecular methods.

Prevalence of malaria and its risk factors in Sabah Malaysia

December 2, 2019 - 15:00 -- Open Access
Author(s): 
Abdul Rahman R, Aniza I, Zetty Sofia MZ
Reference: 
International Journal of Infectious Diseases 2019 Nov 27. pii: S1201-9712(19)30466-7.

This study aims to determine the prevalence of malaria in Sabah and its potential risk factors.

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Evaluation of malaria microscopy diagnostic performance at private health facilities in Tanzania

December 2, 2019 - 14:55 -- Open Access
Author(s): 
Ngasala B, Bushukatale S.
Reference: 
Malaria Journal volume 18, 375 (2019)

The World Health Organization (WHO) recommends use of parasitological diagnosis of malaria for all age groups in all malaria transmission settings. Many private health facilities rely on malaria microscopy for malaria diagnosis. However, quality of malaria microscopy is affected by number of factors including availability of skilled laboratory microscopists and lack of quality assurance systems in many malaria endemic countries. This study was carried out to assess quality of malaria microscopy in selected private health facilities in Tanzania.

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First malaria vaccine rolled out in Africa - despite limited efficacy and nagging safety concerns

November 28, 2019 - 13:29 -- Malaria World

Science, Nov. 26, 2019: by Jop de Vrieze

MALAWI—In a small room at the Phalula Health Centre in southern Malawi's Balaka district, two young mothers are sitting on a wooden bench, each with a 5-month-old baby on their lap. Across from them, behind a desk, sits Alfred Kaponya, a community health worker. A colleague is busy preparing a vaccine, tapping the syringe to dislodge bubbles. Kaponya explains the procedure to the women, writes down the vaccines' serial numbers in the children's vaccination booklets, and copies them onto a spreadsheet in his binder.

Evaluation of the operational capacity of first-line health facilities in the management of malaria in Ivory Coast

November 27, 2019 - 16:29 -- Open Access
Author(s): 
Meless D, Hounsa A, Sangaré A, Pongathié A, Kouakou J, Samba M, Kouadio L.
Reference: 
Pan Afr Med J. 2019 Sep 6;34:16.

Do health facilities (HF) have basic resources needed to manage malaria? The purpose of our study was to analyze the operational capacity (OC) of first-line health facilities in Ivory Coast in the management of malaria.

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Spatio-temporal analysis of association between incidence of malaria and environmental predictors of malaria transmission in Nigeria

November 27, 2019 - 16:17 -- Open Access
Author(s): 
Okunlola OA, Oyeyemi OT
Reference: 
Sci Rep. 2019 Nov 25;9(1):17500.

Malaria still poses a significant threat in Nigeria despite the various efforts to abate its transmission. Certain environmental factors have been implicated to increase the risk of malaria in Nigeria and other affected countries. The study aimed to evaluate the spatial and temporal association between the incidence of malaria and some environmental risk factors in Nigeria. The study used malaria incidence and environmental risk factors data emanating from 2015 Nigeria Malaria Indicator Survey accessed from the Demographic and Health Survey database.

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NOT Open Access | High Circulation of Malaria and Low Prevalence of Bacteremia in Febrile and Afebrile Children in Northeastern Gabon

November 27, 2019 - 16:05 -- NOT Open Access
Author(s): 
Boumbanda Koyo CS, Oyegue-Liabagui SL, Mediannikov O, Cortaredona S, Kouna LC, Raoult D, Lekana-Douki JB, Fenollar F.
Reference: 
Am J Trop Med Hyg. 2019 Nov 25.

The epidemiology of febrile illness etiologies is under-explored in resource-poor settings. Establishing a local repertory of microorganisms circulating in blood of febrile and afebrile people is important for physicians. Blood was collected from 428 febrile and 88 afebrile children in Makokou (Gabon) and analyzed using polymerase chain reaction. Plasmodium spp. were the pathogens, which were most detected in febrile children (69.6%; 298/428) and in afebrile children (31.8%; 28/88) (P < 0.0001). Plasmodium falciparum was the most prevalent species in both febrile and afebrile children (66.8% and 27.3%, respectively).

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