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Semi-field evaluation of the cumulative effects of a “Lethal House Lure” on malaria mosquito mortality

September 10, 2019 - 15:17 -- Open Access
Author(s): 
Antoine M. G. Barreaux, Welbeck A. Oumbouke, Innocent Zran Tia, N’guessan Brou, Alphonsine A. Koffi, Raphaël N’guessan and Matthew B. Thomas
Reference: 
Malaria Journal 2019 18:298, 30 August 2019

There is growing interest in the potential to modify houses to target mosquitoes with insecticides or repellents as they search for human hosts. One version of this ‘Lethal House Lure’ approach is the In2Care® EaveTube, which consists of a section of polyvinyl chloride (PVC) pipe fitted into a closed eave, with an insert comprising electrostatic netting treated with insecticide powder placed inside the tube. Preliminary evidence suggests that when combined with screening of doors and windows, there is a reduction in entry of mosquitoes and an increase in mortality. However, the rate of overnight mortality remains unclear. The current study used a field enclosure built around experimental huts to investigate the mortality of cohorts of mosquitoes over multiple nights.

Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand

September 9, 2019 - 16:40 -- Open Access
Author(s): 
Wen-Qiang He, Stephan Karl, Ivo Mueller, et al.
Reference: 
PLoS Negl Trop Dis 13(8): e0007596

The Plasmodium vivax Reticulocyte Binding Protein (PvRBP) family is involved in red blood cell recognition and members of this family are potential targets for antibodies that may block P. vivax invasion. To date, the acquisition of immunity against PvRBPs in low malaria transmission settings and in a broad age group of exposed individuals has not been investigated.

NOT Open Access | Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes

September 9, 2019 - 16:37 -- NOT Open Access
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Author(s): 
Eunice O Oshomah-Bello, Christopher I Esezobor, Adaobi U Solarin, Fidelis O Njokanma
Reference: 
Journal of Tropical Pediatrics, fmz057

The prevalence of acute kidney injury (AKI) in children with severe malaria in sub-Saharan African may have been underestimated. The study aimed to determine the prevalence of AKI in children with severe malaria and its association with adverse hospital outcomes.

Fipronil and ivermectin treatment of cattle reduced the survival and ovarian development of field-collected Anopheles albimanus in a pilot trial conducted in northern Belize

September 3, 2019 - 15:38 -- Open Access
Author(s): 
Staci M. Dreyer, Donovan Leiva, Marla Magaña, Marie Pott, Jonathan Kay, Alvaro Cruz, Nicole L. Achee, John P. Grieco and Jefferson A. Vaughan
Reference: 
Malaria Journal 2019 18:296, 29 August 2019

Most malaria vector control programmes rely on indoor residual spraying of insecticides and insecticide-treated bed nets. This is effective against vector species that feed indoors at night and rest inside the house afterwards. In Central America, malaria vectors have different behaviours and are typically exophagic (i.e., bite outdoors), exophilic (i.e., remain outdoors after feeding), and zoophagic (i.e., as likely to feed on non-humans as humans). Thus, malaria elimination in Central America may require additional tactics. This pilot study investigated whether commercially-available products used to treat livestock for ticks could also be used to kill and/or sterilize zoophagic malaria vectors that feed on treated cattle in Belize.

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Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi

September 3, 2019 - 15:22 -- Open Access
Author(s): 
Agata Negri, Marco Ferrari, Riccardo Nodari, Edoardo Coppa, Valentina Mastrantonio, Sergio Zanzani, Daniele Porretta, Claudio Bandi, Sandra Urbanelli and Sara Epis
Reference: 
Malaria Journal 2019 18:294, 28 August 201

Insecticides are still at the core of insect pest and vector control programmes. Several lines of evidence indicate that ABC transporters are involved in detoxification processes against insecticides, including permethrin and other pyrethroids. In particular, the ABCG4 gene, a member of the G subfamily, has consistently been shown to be up-regulated in response to insecticide treatments in the mosquito malaria vector Anopheles stephensi (both adults and larvae).

ELQ-331 as a prototype for extremely durable chemoprotection against malaria

September 2, 2019 - 15:25 -- Open Access
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Author(s): 
Martin J. Smilkstein, Sovitj Pou, Jane X. Kelly, et al.
Reference: 
Malaria Journal 2019 18:291, 27 August 2019

The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynamic and pharmacokinetic profiles after oral dosing, ELQ-331, a prodrug of the parasite mitochondrial electron transport inhibitor ELQ-300, was selected for study of pharmacokinetics and efficacy as LAI-C in mice.

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Field performance of the malaria highly sensitive rapid diagnostic test in a setting of varying malaria transmission

September 2, 2019 - 15:13 -- Open Access
Tags: 
Author(s): 
Julia Mwesigwa, Hannah Slater, Umberto D’Alessandro, et al.
Reference: 
Malaria Journal 2019 18:288, 27 August 2019

The Gambia has successfully reduced malaria transmission. The human reservoir of infection could further decrease if malaria-infected individuals could be identified by highly sensitive, field-based, diagnostic tools and then treated.

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The impact on malaria of biannual treatment with azithromycin in children age less than 5 years: a prospective study

August 27, 2019 - 22:00 -- Open Access
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Author(s): 
Evan M. Bloch, Beatriz Munoz, Zakayo Mrango, Jerusha Weaver, Leonard E. G. Mboera, Tom M. Lietman, David J. Sullivan Jr. and Sheila K. West
Reference: 
Malaria Journal 2019 18:284, 23 August 2019

The MORDOR study, a cluster randomized clinical trial, showed that single-dose azithromycin (20 mg/kg) administered biannually for 2 years to preschool children reduced mortality; a study was conducted to determine its effect on clinical symptomatic episodes of malaria as a potential mechanism for mortality benefit.

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Mapping and enumerating houses and households to support malaria control interventions on Bioko Island

August 27, 2019 - 21:57 -- Open Access
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Author(s): 
Guillermo A. García, Dianna E. B. Hergott, Carlos A. Guerra, et al.
Reference: 
Malaria Journal 2019 18:283, 22 August 2019

Housing mapping and household enumeration are essential for the planning, implementation, targeting, and monitoring of malaria control interventions. In many malaria endemic countries, control efforts are hindered by incomplete or non-existent housing cartography and household enumeration. This paper describes the development of a comprehensive mapping and enumeration system to support the Bioko Island Malaria Control Project (BIMCP).

Using a miniaturized double-net trap (DN-Mini) to assess relationships between indoor–outdoor biting preferences and physiological ages of two malaria vectors, Anopheles arabiensis and Anopheles funestus

August 27, 2019 - 21:56 -- Open Access
Author(s): 
Alex J. Limwagu, Emmanuel W. Kaindoa, Fredros O. Okumu, et al.
Reference: 
Malaria Journal 2019 18:282, 22 August 2019

Effective malaria surveillance requires detailed assessments of mosquitoes biting indoors, where interventions such as insecticide-treated nets work best, and outdoors, where other interventions may be required. Such assessments often involve volunteers exposing their legs to attract mosquitoes [i.e., human landing catches (HLC)], a procedure with significant safety and ethical concerns. Here, an exposure-free, miniaturized, double-net trap (DN-Mini) is used to assess relationships between indoor–outdoor biting preferences of malaria vectors, Anopheles arabiensis and Anopheles funestus, and their physiological ages (approximated by parity and insemination states).

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