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Critique of WHO 2017 Malaria Report

December 11, 2017 - 17:21 -- William Jobin
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The 2017 WHO report on the status of malaria at the end of 2016 is a mixture of good news and bad news, with the bad news predominating. Although Dr. Tedros, the Director General of WHO and Prof. Alonso, the Director of the Global Malaria Program are to be commended for their frank presentation of the negative trends, they need to identify the reasons for these trends if we are to make the changes needed to reverse them.

Thus I will attempt herein to analyze some of the reasons for these negative trends, and suggest changes needed if we are to overcome them.

Collective Reviews: malERA: An updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication

December 7, 2017 - 15:30 -- Open Access
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Author(s): 
The malERA Refresh Consultative Panel on Combination Interventions and Modelling
Reference: 
PLoS Med 14(11): e1002452

This paper summarises key advances in defining the infectious reservoir for malaria and the measurement of transmission for research and programmatic use since the Malaria Eradication Research Agenda (malERA) publication in 2011.

Collection Reviews: malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

December 7, 2017 - 15:29 -- Open Access
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Author(s): 
The malERA Refresh Consultative Panel on Basic Science and Enabling Technologies
Reference: 
PLoS Med 14(11): e1002451

Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions.

Collection Reviews: malERA: An updated research agenda for insecticide and drug resistance in malaria elimination and eradication

December 7, 2017 - 15:28 -- Open Access
Author(s): 
The malERA Refresh Consultative Panel on Insecticide and Drug Resistance
Reference: 
PLoS Med 14(11): e1002450

Resistance to first-line treatments for Plasmodium falciparum malaria and the insecticides used for Anopheles vector control are threatening malaria elimination efforts.

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Malaria Prevalence, Indoor Residual Spraying, and Insecticide Treated Net Usage in Sub-Saharan Africa

December 7, 2017 - 15:26 -- Open Access
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Author(s): 
Gabriel Picone, Robyn Kibler, and Bénédicte H. Apouey
Reference: 
Journal of African Development (2017) 19:19–32

This  paper  examines  the  extent  to  which  bed  net  usage  is  responsive  to changes  in  malaria   prevalence  and  whether  indoor  residual  spraying  crowds  out  bed  net  usage. 

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NOT Open Access | Clinical Predictors of Malaria, Acute Bacterial Meningitis and Treatment Outcomes among Febrile Children Admitted with Altered Mental Status in Northwestern Tanzania

December 4, 2017 - 15:20 -- NOT Open Access
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Author(s): 
Shakilu Jumanne, John Meda, Adolfine Hokororo, Kelvin Leshabari
Reference: 
Journal of Tropical Pediatrics, fmx090, 30 November 2017

Children with febrile encephalopathy are more likely to have malaria than ABM if they have severe anemia.

NOT Open Access | Ionic liquid mediated stereoselective synthesis of alanine linked hybrid quinazoline-4(3H)-one derivatives perturbing the malarial reductase activity in folate pathway

November 30, 2017 - 14:54 -- NOT Open Access
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Author(s): 
Tarosh S. Patel, Jaimin D. Bhatt, Satish F. Vanparia, Urmila H. Patel, Ritu B. Dixit, Chaitanya J. Chudasama, Bhavesh D. Patel, Bharat C. Dixit
Reference: 
Bioorganic & Medicinal Chemistry, Volume 25, Issue 24, 15 December 2017, Pages 6635-6646

Grimmel’s method was optimized as well as modified leading to the cyclization and incorporation of alanine linked sulphonamide in 4-quinazolin-(3H)-ones.

NOT Open Access | Protective efficacy of an IL-12-expressing baculoviral malaria vaccine

November 30, 2017 - 14:48 -- NOT Open Access
Author(s): 
M. Iyori, A. M. Blagborough, K. A. Sala, H. Nishiura, K. Takagi and S. Yoshida
Reference: 
Parasite Immunology, olume 39, Issue 12 December 2017, e12498

Interleukin-12 (IL-12) plays an important role in antigen-specific adaptive immunity against Plasmodium sporozoites, and this requirement allows for a new approach to developing an effective malaria vaccine.

Novel ELISA method as exploratory tool to assess immunity induced by radiated attenuated sporozoites to decipher protective immunity

November 29, 2017 - 15:43 -- Open Access
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Author(s): 
Trey A. Knepper, Elizabeth H. Duncan, Tatyana Savransky and Elke S. Bergmann-Leitner
Reference: 
Malaria Journal 2017 16:484, 29 November 2017

Applying this simple and highly reproducible approach to assess immune responses induced by malaria vaccines, both recombinant and whole parasite vaccines, (1) will help in the evaluation of immune responses induced by antigenically complex malaria vaccines such as the irradiated SPZ-vaccine, (2) will facilitate and accelerate the identification of immune correlates of protection, and (3) can also be a valuable assessment tool for antigen discovery as well as down-selection of vaccine formulations and, thereby, guide vaccine design.

RDL mutations predict multiple insecticide resistance in Anopheles sinensis in Guangxi, China

November 29, 2017 - 15:36 -- Open Access
Author(s): 
Chan Yang, Zushi Huang, Mei Li, Xiangyang Feng and Xinghui Qiu
Reference: 
Malaria Journal 2017 16:482, 28 November 2017

 

The near fixation of the 296S mutation and the occurrence of the 327I and 345S mutations in addition to 296S, in all the nine tested An. sinensis populations in Guangxi, strongly indicate a risk of multiple insecticide resistance.

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