A marked decrease in malaria-related deaths worldwide has been attributed to the administration of effective antimalarials against Plasmodium falciparum, in particular, artemisinin-based combination therapies (ACTs).
Although it is generally agreed that an effective vaccine would greatly accelerate the control of malaria, the lone registered malaria vaccine Mosquirix™ has an efficacy of 30%-60% that wanes rapidly, indicating a need for improved second-generation malaria vaccines.
The transmission of Plasmodium within a vertebrate host population is strongly associated with the life history traits of its vector.
Conclusive evidence for relapses with P. ovale spp. is rare.
To limit the spread and impact of anti-malarial drug resistance and react accordingly, surveillance systems able to detect and track in real-time its emergence and spread need to be strengthened or in some places established.
There are a limited number of studies which have simultaneously evaluated both environmental and interventional effects on malaria risk
Consistent AO staining of thin blood films and rapid evaluation of malaria parasitaemia with the revised protocol produced superior results relative to the Giemsa method.
It has long been believed that latency was only present in Plasmodium vivax or Plasmodium ovale due to hypnozoites, exo-erythrocytic forms in the liver. The prevailing opinion until the middle of the last century was that the maximum duration of Plasmodium falciparum infections was less than 2 years. But asymptomatic carriers are common in endemic areas and the transfer of the parasites to nonimmune patients by blood transfusion is common knowledge. And in many cases the donors have been absent from countries with exposure to malaria for durations longer than 2 years.
Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide.
Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics.