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NOT Open Access | Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase-Deficient Malaria Patient in Southeastern Bangladesh

November 12, 2019 - 16:16 -- NOT Open Access
Author(s): 
Phru CS, Kibria MG, Thriemer K, Chowdhury MU, Jahan N, Aktaruzzaman MM, Rahmat H, Satyagraha AW, Prue AS, Khan WA, Ley B, Alam MS.
Reference: 
Am J Trop Med Hyg. 2019 Nov 4

We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated Plasmodium vivax infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days.

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NOT Open Access | Estimation of Malaria-Attributable Fever in Malaria Test-Positive Febrile Outpatients in Three Provinces of Mozambique, 2018

November 12, 2019 - 16:13 -- NOT Open Access
Author(s): 
Plucinski MM, Candrinho B, Dimene M, Smith T, Thwing J, Colborn J, Rogier E, Zulliger R.
Reference: 
Am J Trop Med Hyg. 2019 Nov 4

Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria test–positive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology.

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Trypanosoma brucei infection protects mice against malaria

November 12, 2019 - 16:10 -- Open Access
Author(s): 
Sanches-Vaz M, Temporão A, Luis R, Nunes-Cabaço H, Mendes AM, Goellner S, Carvalho T, Figueiredo LM, Prudêncio M.
Reference: 
PLoS Pathog. 2019 Nov 8;15(11):e1008145

Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness, would inhibit a subsequent infection by Plasmodium, the malaria parasite, decreasing the severity of its associated pathology.

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Non-adherence to malaria prophylaxis: The influence of travel-related and psychosocial factors

November 12, 2019 - 15:59 -- Open Access
Author(s): 
Jolanda G.M. Hoefnagel, Karlijn Massar, Jeannine L.A. Hautvast
Reference: 
Journal of Infection and Public Health, 6 November 2019

The effectiveness of malaria chemoprophylaxis is limited by a lack of compliance in travellers. This study assesses the demographic, travel-related, and psychosocial determinants of non-compliance with chemoprophylaxis.

Determinants of malaria treatment delay in northwestern zone of Tigray region, Northern Ethiopia, 2018

November 11, 2019 - 16:20 -- Open Access
Author(s): 
Afewerki Tesfahunegn, Dawit Zenebe and Alefech Addisu
Reference: 
Malaria Journal 2019 18:358, 9 November 2019

Globally malaria affects 212 million people and causes 438,000 deaths each year. Ensuring early and timely treatment of malaria is important for preventing and controlling of life-threatening complications and further transmission. 

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The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

November 11, 2019 - 16:13 -- Open Access
Author(s): 
Shwu-Maan Lee, Yimin Wu, John M. Hickey, Kazutoyo Miura, Neal Whitaker, Sangeeta B. Joshi, David B. Volkin, C. Richter King and Jordan Plieskatt
Reference: 
Malaria Journal 2019 18:356, 8 November 2019

Control and elimination of malaria can be accelerated by transmission-blocking interventions such as vaccines. A surface antigen of Plasmodium falciparum gametocytes, Pfs230, is a leading vaccine target antigen, and has recently progressed to experimental clinical trials. To support vaccine product development, an N-terminal Pfs230 antigen was designed to increase yield, as well as to improve antigen quality, integrity, and homogeneity.

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Diagnostic performance of CareStart™ malaria HRP2/pLDH test in comparison with standard microscopy for detection of uncomplicated malaria infection among symptomatic patients, Eastern Coast of Tanzania

November 11, 2019 - 16:02 -- Open Access
Author(s): 
George M. Bwire, Billy Ngasala, Manase Kilonzi, Wigilya P. Mikomangwa, Fatuma F. Felician and Appolinary A. R. Kamuhabwa
Reference: 
Malaria Journal 2019 18:354, 5 November 2019

CareStart™ malaria HRP2/pLDH (Pf/pan) combo test is one of the several rapid diagnostic tests (RDT) approved for diagnosis of malaria at the point of care in Tanzania. However, there are limited studies on the diagnostic performance of RDT after wide scale use in primary health care facilities in Tanzania. 

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Corrigendum: Chronic Exposure to Malaria Is Associated with Inhibitory and Activation Markers on Atypical Memory B Cells and Marginal Zone-Like B Cells

November 7, 2019 - 22:03 -- Open Access
Author(s): 
Ubillos I, Campo JJ, Requena P, Ome-Kaius M, Hanieh S, Rose H, Samol P, Barrios D, Jiménez A, Bardají A, Mueller I, Menéndez C, Rogerson S, Moncunill G, Dobaño C.
Reference: 
Front Immunol. 2019 Oct 17;10:2427 (eCollection 2019)

In the original article, we neglected to include the co-funder “FEDER funds/European Regional Development Fund (ERDF)” to “Instituto de Salud Carlos III (grant number PI14/01422)”.

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A Viral-Vectored Multi-Stage Malaria Vaccine Regimen With Protective and Transmission-Blocking Efficacies

November 7, 2019 - 21:56 -- Open Access
Author(s): 
Yusuf Y, Yoshii T, Iyori M, Mizukami H, Fukumoto S, Yamamoto DS, Emran TB, Amelia F, Islam A, Syafira I, Yoshida S
Reference: 
Front Immunol. 2019 Oct 15;10:2412 (eCollection 2019)

Malaria parasites undergo several stages in their complex lifecycle. To achieve reductions in both the individual disease burden and malaria transmission within communities, a multi-stage malaria vaccine with high effectiveness and durability is a more efficacious strategy compared with a single-stage vaccine.

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Not Open Access | First report of Glucose-6-phosphate dehydrogenase (G6PD) variants (Mahidol and Acores) from malaria-endemic regions of northeast India and their functional evaluations in silico

November 7, 2019 - 21:44 -- NOT Open Access
Author(s): 
Bharti RS, Vashisht K, Ahmed N, Nayak A, Pande V, Mishra N
Reference: 
Acta Trop. 2019 Oct 31:105252 [Epub ahead of print]

G6PD deficiency results from numerous mutations in the G6PD gene and can cause alterations in enzyme function up to varying degrees. P. vivax malaria infections require G6PD deficiency screening because of the potential risk of haemolysis by the gametocytocidal drug (primaquine) during the radical treatment.

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