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Decision support for evidence-based integration of disease control: A proof of concept for malaria and schistosomiasis

April 19, 2018 - 15:33 -- Open Access
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Author(s): 
Claire J. Standley, Ellie Graeden, Justin Kerr, Erin M. Sorrell, Rebecca Katz
Reference: 
PLoS Negl Trop Dis 12(4): e0006328

Managing infectious disease requires rapid and effective response to support decision making.

Development of an autodissemination strategy for the deployment of novel control agents targeting the common malaria mosquito, Anopheles quadrimaculatus say (Diptera: Culicidae)

April 19, 2018 - 15:32 -- Open Access
Author(s): 
Daniel R. Swale, Zhilin Li, Jake Z. Kraft, Kristen Healy, Mei Liu, Connie M. David, Zhijun Liu, Lane D. Foil
Reference: 
PLoS Negl Trop Dis 12(4): e0006259

Novaluron can be transferred to the adult at a greater efficacy and/or is not degraded as quickly during the gonotropic cycle when compared to pyriproxyfen or triflumuron.

Not Open Access | Plasmodium-associated changes in human odor attract mosquitoes

April 19, 2018 - 15:26 -- NOT Open Access
Author(s): 
Ailie Robinson, Annette O. Busula, Jetske G. de Boer, et al.
Reference: 
PNAS April 16, 2018. 201721610

Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission.

Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection

April 18, 2018 - 15:02 -- Open Access
Author(s): 
Michael M. Opata, Samad A. Ibitokou, Victor H. Carpio, Karis M. Marshall, Brian E. Dillon, Jordan C. Carl, Kyle D. Wilson, Christine M. Arcari, Robin Stephens
Reference: 
PLoS Pathog 14(4): e1006960

Protection at the peak of Plasmodium chabaudi blood-stage malaria infection is provided by CD4 T cells.

Alpha-v–containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP

April 18, 2018 - 15:01 -- Open Access
Author(s): 
Kirsten Dundas, Melanie J. Shears, Yi Sun, Christine S. Hopp, Cecile Crosnier, Tom Metcalf, Gareth Girling, Photini Sinnis, Oliver Billker and Gavin J. Wright
Reference: 
PNAS April 9, 2018. 201719660

Malaria-causing Plasmodium sporozoites are deposited in the dermis by the bite of an infected mosquito and move by gliding motility to the liver where they invade and develop within host hepatocytes.

Plasmodium vivax and Plasmodium falciparum infection dynamics: re-infections, recrudescences and relapses

April 17, 2018 - 16:05 -- Open Access
Author(s): 
Michael T. White, Stephan Karl, Ivo Mueller, et al.
Reference: 
Malaria Journal 2018 17:170, 17 April 2018

The statistical model developed here provides a useful new tool for in-depth analysis of malaria data from longitudinal cohort studies, and future application to data sets with multi-locus genotyping will allow more detailed investigation of infection dynamics.

Socioeconomic health inequality in malaria indicators in rural western Kenya: evidence from a household malaria survey on burden and care-seeking behaviour

April 17, 2018 - 16:03 -- Open Access
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Author(s): 
Vincent Were, Ann M. Buff, Louis Niessen, et al.
Reference: 
Malaria Journal 2018 17:166, 16 April 2018

Inequalities in malaria infection and expenditures on potentially ineffective malaria medication between the poorest and less-poor households were evident in rural western Kenya.

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Factors associated with treatment-seeking for malaria in urban poor communities in Accra, Ghana

April 17, 2018 - 16:02 -- Open Access
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Author(s): 
Raphael Baffour Awuah, Paapa Yaw Asante, Lionel Sakyi, Adriana A. E. Biney, Mawuli Komla Kushitor, Francis Agyei and Ama de-Graft Aikins
Reference: 
Malaria Journal 2018 17:168, 16 April 2018

The findings show that many urban poor residents in Accra self-medicate as the first response to malaria.

Country: 

Presence of novel triple mutations in the pvdhfr from Plasmodium vivax in Mangaluru city area in the southwestern coastal region of India

April 17, 2018 - 16:01 -- Open Access
Author(s): 
Shiny Joy, Susanta K. Ghosh, Rajeshwara N. Achur, D. Channe Gowda and Namita Surolia
Reference: 
Malaria Journal 2018 17:167, 16 April 2018

The current study indicates that P. vivax dhps and dhfr mutant alleles are prevalent in this area, suggesting significant SP pressure.

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Application of the automated haematology analyzer XN-30 in an experimental rodent model of malaria

April 17, 2018 - 15:57 -- Open Access
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Author(s): 
Takahiro Tougan, Yuhgi Suzuki, Munehisa Izuka, Kei Aono, Tomonori Okazaki, Yuji Toya, Kinya Uchihashi and Toshihiro Horii
Reference: 
Malaria Journal 2018 17:165, 16 April 2018

The XN-30 system is a powerful tool that can be utilized for the in vivo screening, development, and evaluation of anti-malarial drugs as well as for pre-clinical pharmacology and/or toxicity tests in rodent models.

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