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NOT Open Access | Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations

June 21, 2017 - 15:40 -- NOT Open Access
Author(s): 
Maxmillian Mpina, Nicholas J. Maurice, Martin Prlic, et al.
Reference: 
The Journal of Immunology, Vol. 199, Issue 1, 1 Jul 2017

Animal model studies highlight the role of innate-like lymphocyte populations in the early inflammatory response and subsequent parasite control following Plasmodium infection.

Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malaria parasite, Plasmodium chabaudi

June 21, 2017 - 15:37 -- Open Access
Author(s): 
Lorena González-López, Rebeca Carballar-Lejarazú, Fidel de la Cruz Hernández-Hernández, et al.
Reference: 
PLoS ONE 12(6): e0176533

Ubiquitination tags proteins for different functions within the cell. One of the most abundant and studied ubiquitin modification is the Lys48 polyubiquitin chain that modifies proteins for their destruction by proteasome.

NOT Open Access | Malaria overdiagnosis and subsequent overconsumption of antimalarial drugs in Angola: Consequences and effects on human health

June 20, 2017 - 14:34 -- NOT Open Access
Tags: 
Author(s): 
Sylvie Manguin, Vincent Foumane, Patrick Besnard, Filomeno Fortes, Pierre Carnevale
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 58–63

Microscopic blood smear examinations done in health centers of Angola demonstrated a large overdiagnosis of malaria cases with an average rate of errors as high as 85%.

Medical Treatment: 

NOT Open Access | Therapeutic efficacy of chloroquine for the treatment of Plasmodium vivax malaria among outpatients at Shawa Robit Health Care Centre, North-East Ethiopia

June 20, 2017 - 14:33 -- NOT Open Access
Author(s): 
Seble Seifu, Ahmed Zeynudin, Endalew Zemene, Sultan Suleman, Abdissa Biruksew
Reference: 
Acta Tropica, Volume 171, July 2017, Pages 44–51

Nearly 40% of all malaria infection in Ethiopia is caused by Plasmodium vivax. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country.

Medical Treatment: 

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite

June 20, 2017 - 14:31 -- Open Access
Author(s): 
Upeksha L. Rathnapala, Christopher D. Goodman, Geoffrey I. McFadden
Reference: 
PLoS Pathog 13(6): e1006396

The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty means that malaria remains a major global health crisis.

NOT Open Access | Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor

June 20, 2017 - 14:29 -- NOT Open Access
Author(s): 
Joana Mendonca Santos, Gabrielle Josling, Philipp Ross, Preeti Joshi, Lindsey Orchard, Tracey Campbell, Ariel Schieler, Ileana M. Cristea, Manuel Llinás
Reference: 
Cell Host & Microbe, Volume 21, Issue 6, 14 June 2017, Pages 731–741.e10

Obligate intracellular parasites must efficiently invade host cells in order to mature and be transmitted.

Perennial transmission of malaria in the low altitude areas of Baringo County, Kenya

June 20, 2017 - 14:22 -- Open Access
Tags: 
Author(s): 
Collince J. Omondi, Daniel Onguru, Lucy Kamau, Mark Nanyingi, George Ong’amo and Benson Estambale
Reference: 
Malaria Journal 2017 16:257, 17 June 2017

Malaria infection was prevalent in Baringo County and was mainly restricted to the riverine zone where transmission is continuous throughout the year.

New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission

June 15, 2017 - 15:44 -- Open Access
Author(s): 
Kathleen A. McGuire, Kazutoyo Miura, Christopher M. Wiethoff and Kim C. Williamson
Reference: 
Malaria Journal 2017 16:254, 15 June 2017

The data suggest that focusing the immune response against defined epitopes displayed on the viral capsid is an effective strategy for transmission-blocking vaccine development.

G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon

June 15, 2017 - 15:43 -- Open Access
Tags: 
Author(s): 
Jamille G. Dombrowski, Rodrigo M. Souza, Claudio R. F. Marinho, et al.
Reference: 
Malaria Journal 2017 16:253, 15 June 2017

The data indicates that ~1/23 males from the Alto do Juruá could be G6PD deficient and at risk of haemolytic anaemia if treated with primaquine.

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Medical Condition: 

The US President’s Malaria Initiative and under-5 child mortality in sub-Saharan Africa: A difference-in-differences analysis

June 15, 2017 - 15:30 -- Open Access
Tags: 
Author(s): 
Aleksandra Jakubowski, Sally C. Stearns, Margaret E. Kruk, Gustavo Angeles, Harsha Thirumurthy
Reference: 
PLoS Med 14(6): e1002319

PMI may have significantly contributed to reducing the burden of malaria in SSA and reducing the number of child deaths in the region.

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