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NOT Open Access | Drug resistance in Plasmodium

February 14, 2018 - 15:55 -- NOT Open Access
Kasturi Haldar, Souvik Bhattacharjee & Innocent Safeukui
Nature Reviews Microbiology volume 16, pages 156–170 (2018)

A marked decrease in malaria-related deaths worldwide has been attributed to the administration of effective antimalarials against Plasmodium falciparum, in particular, artemisinin-based combination therapies (ACTs).

Preclinical efficacy and immunogenicity assessment to show that a chimeric Plasmodium falciparum UB05-09 antigen could be a malaria vaccine candidate

February 14, 2018 - 15:54 -- Open Access
J. N. Dinga, S. D. Gamua, S. M. Ghogomu and V. P. K. Titanji
Parasite Immunology, Volume 40, Issue 3 March 2018, e12514

Although it is generally agreed that an effective vaccine would greatly accelerate the control of malaria, the lone registered malaria vaccine Mosquirix™ has an efficacy of 30%-60% that wanes rapidly, indicating a need for improved second-generation malaria vaccines.

Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection

February 13, 2018 - 15:50 -- Open Access
Luzia Veletzky, Mirjam Groger, Heimo Lagler, Julia Walochnik, Herbert Auer, Hans-Peter Fuehrer and Michael Ramharter
Malaria Journal 2018 17:78, 9 February 2018

Conclusive evidence for relapses with P. ovale spp. is rare.

Tools for surveillance of anti-malarial drug resistance: an assessment of the current landscape

February 13, 2018 - 15:33 -- Open Access
Christian Nsanzabana, Djibrine Djalle, Philippe J. Guérin, Didier Ménard and Iveth J. González
Malaria Journal 2018 17:75, 8 February 2018

To limit the spread and impact of anti-malarial drug resistance and react accordingly, surveillance systems able to detect and track in real-time its emergence and spread need to be strengthened or in some places established.

The associations between malaria, interventions, and the environment: a systematic review and meta-analysis

February 13, 2018 - 15:30 -- Open Access
Margaux L. Sadoine, Audrey Smargiassi, Valéry Ridde, Lucy S. Tusting and Kate Zinszer
Malaria Journal 2018 17:73, 7 February 2018

There are a limited number of studies which have simultaneously evaluated both environmental and interventional effects on malaria risk

Improvement of malaria diagnostic system based on acridine orange staining

February 12, 2018 - 15:35 -- Open Access
Masatsugu Kimura, Isao Teramoto, Chim W. Chan, Zulkarnain Md Idris, James Kongere, Wataru Kagaya, Fumihiko Kawamoto, Ryoko Asada, Rie Isozumi and Akira Kaneko
Malaria Journal 2018 17:72, 7 February 2018

Consistent AO staining of thin blood films and rapid evaluation of malaria parasitaemia with the revised protocol produced superior results relative to the Giemsa method.

Vaccines, antimalarials and recrudescence

February 12, 2018 - 12:38 -- Pierre Lutgen

It has long been believed that latency was only present in Plasmodium vivax or Plasmodium ovale due to hypnozoites, exo-erythrocytic forms in the liver. The prevailing opinion until the middle of the last century was that the maximum duration of Plasmodium falciparum infections was less than 2 years. But asymptomatic carriers are common in endemic areas and the transfer of the parasites to nonimmune patients by blood transfusion is common knowledge. And in many cases the donors have been absent from countries with exposure to malaria for durations longer than 2 years.

NOT Open Access | New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness

February 10, 2018 - 15:52 -- NOT Open Access
Markus Ritzefield, Megan H. Wright, Edward W. Tate
Parasitology, Volume 145 / Issue 2, February 2018, pp 157 – 174

Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide.

Schistosoma mansoni infection suppresses the growth of Plasmodium yoelii parasites in the liver and reduces gametocyte infectivity to mosquitoes

February 10, 2018 - 15:51 -- Open Access
Taeko Moriyasu, Risa Nakamura, Sharmina Deloer, Masachika Senba, Masato Kubo, Megumi Inoue, Richard Culleton, Shinjiro Hamano
PLoS Negl Trop Dis 12(1): e0006197

Malaria and schistosomiasis are major parasitic diseases causing morbidity and mortality in the tropics.


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