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Malaria eradication within a generation: ambitious, achievable, and necessary

September 11, 2019 - 16:03 -- Open Access
Richard G A Feachem, Ingrid Chen, Winnie Mpanju-Shumbusho, et al.
The Lancet, September 08, 2019

In the first report of its kind and with a bold vision, the Commission lays the out the necessary steps, including an even greater financial outlay, strengthening malaria programmes and global leadership, and acceleration of research and development, to eradicate malaria within a generation.

Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review

September 10, 2019 - 15:34 -- Open Access
Abel Kakuru, Sarah G. Staedke, Grant Dorsey, Stephen Rogerson and Daniel Chandramohan
Malaria Journal 2019 18:304, 3 September 2019

Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp), on the risk of clinical malaria or parasitaemia during infancy.


Malaria around large dams in Africa: effect of environmental and transmission endemicity factors

September 10, 2019 - 15:32 -- Open Access
Solomon Kibret, Jonathan Lautze, Matthew McCartney, Luxon Nhamo and Guiyun Yan
Malaria Journal 2019 18:303, 3 September 2019

The impact of large dams on malaria has received widespread attention. However, understanding how dam topography and transmission endemicity influence malaria incidences is limited.

Applying next-generation sequencing to track falciparum malaria in sub-Saharan Africa

September 10, 2019 - 15:31 -- Open Access
Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse
Malaria Journal 2019 18:268, 3 September 2019

Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions.

Evaluating synthetic odours and trap designs for monitoring Anopheles farauti in Queensland, Australia

September 10, 2019 - 15:18 -- Open Access
Bram van de Straat, Alexandra Hiscox, Willem Takken and Thomas R. Burkot
Malaria Journal 2019 18:299, 2 September 2019

Monitoring of malaria vectors is important for designing and maintaining effective control interventions as changes in vector-feeding habits can threaten the efficacy of interventions. At present, human landing catches remain the most common method for monitoring malaria vectors of the Anopheles punctulatus complex, including the Anopheles farauti group. The aims of this study were to evaluate the efficacy of different lures and fan-powered traps, including an odour blend that has been demonstrated to be attractive to African anophelines, in Queensland, Australia.


Semi-field evaluation of the cumulative effects of a “Lethal House Lure” on malaria mosquito mortality

September 10, 2019 - 15:17 -- Open Access
Antoine M. G. Barreaux, Welbeck A. Oumbouke, Innocent Zran Tia, N’guessan Brou, Alphonsine A. Koffi, Raphaël N’guessan and Matthew B. Thomas
Malaria Journal 2019 18:298, 30 August 2019

There is growing interest in the potential to modify houses to target mosquitoes with insecticides or repellents as they search for human hosts. One version of this ‘Lethal House Lure’ approach is the In2Care® EaveTube, which consists of a section of polyvinyl chloride (PVC) pipe fitted into a closed eave, with an insert comprising electrostatic netting treated with insecticide powder placed inside the tube. Preliminary evidence suggests that when combined with screening of doors and windows, there is a reduction in entry of mosquitoes and an increase in mortality. However, the rate of overnight mortality remains unclear. The current study used a field enclosure built around experimental huts to investigate the mortality of cohorts of mosquitoes over multiple nights.

Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand

September 9, 2019 - 16:40 -- Open Access
Wen-Qiang He, Stephan Karl, Ivo Mueller, et al.
PLoS Negl Trop Dis 13(8): e0007596

The Plasmodium vivax Reticulocyte Binding Protein (PvRBP) family is involved in red blood cell recognition and members of this family are potential targets for antibodies that may block P. vivax invasion. To date, the acquisition of immunity against PvRBPs in low malaria transmission settings and in a broad age group of exposed individuals has not been investigated.

NOT Open Access | Acute Kidney Injury in Children with Severe Malaria Is Common and Associated with Adverse Hospital Outcomes

September 9, 2019 - 16:37 -- NOT Open Access
Eunice O Oshomah-Bello, Christopher I Esezobor, Adaobi U Solarin, Fidelis O Njokanma
Journal of Tropical Pediatrics, fmz057

The prevalence of acute kidney injury (AKI) in children with severe malaria in sub-Saharan African may have been underestimated. The study aimed to determine the prevalence of AKI in children with severe malaria and its association with adverse hospital outcomes.

Fipronil and ivermectin treatment of cattle reduced the survival and ovarian development of field-collected Anopheles albimanus in a pilot trial conducted in northern Belize

September 3, 2019 - 15:38 -- Open Access
Staci M. Dreyer, Donovan Leiva, Marla Magaña, Marie Pott, Jonathan Kay, Alvaro Cruz, Nicole L. Achee, John P. Grieco and Jefferson A. Vaughan
Malaria Journal 2019 18:296, 29 August 2019

Most malaria vector control programmes rely on indoor residual spraying of insecticides and insecticide-treated bed nets. This is effective against vector species that feed indoors at night and rest inside the house afterwards. In Central America, malaria vectors have different behaviours and are typically exophagic (i.e., bite outdoors), exophilic (i.e., remain outdoors after feeding), and zoophagic (i.e., as likely to feed on non-humans as humans). Thus, malaria elimination in Central America may require additional tactics. This pilot study investigated whether commercially-available products used to treat livestock for ticks could also be used to kill and/or sterilize zoophagic malaria vectors that feed on treated cattle in Belize.


Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi

September 3, 2019 - 15:22 -- Open Access
Agata Negri, Marco Ferrari, Riccardo Nodari, Edoardo Coppa, Valentina Mastrantonio, Sergio Zanzani, Daniele Porretta, Claudio Bandi, Sandra Urbanelli and Sara Epis
Malaria Journal 2019 18:294, 28 August 201

Insecticides are still at the core of insect pest and vector control programmes. Several lines of evidence indicate that ABC transporters are involved in detoxification processes against insecticides, including permethrin and other pyrethroids. In particular, the ABCG4 gene, a member of the G subfamily, has consistently been shown to be up-regulated in response to insecticide treatments in the mosquito malaria vector Anopheles stephensi (both adults and larvae).


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