The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10588 malaria professionals are enjoying the free benefits of MalariaWorld today

malaria

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives

September 24, 2020 - 14:05 -- Open Access
Author(s): 
Zhang XL, Li ZM, Ye JT, Lu J, Ye LL, Zhang CX, Liu PQ, Duan DD
Reference: 
Acta Pharmacol Sin. 2020 Sep 23

The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hydroxychloroquine, which have been used in the treatment and prevention of malaria and autoimmune diseases for decades, were found to inhibit SARS-CoV-2 infection with high potency in vitro and have shown clinical and virologic benefits in COVID-19 patients.

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

September 24, 2020 - 14:02 -- Open Access
Author(s): 
Harding CR, Sidik SM, Petrova B, Gnädig NF, Okombo J, Herneisen AL, Ward KE, Markus BM, Boydston EA, Fidock DA, Lourido S
Reference: 
Nat Commun. 2020 Sep 23;11(1):4813.

Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however, resistance threatens to undermine global control efforts. To broadly explore artemisinin susceptibility in apicomplexan parasites, we employ genome-scale CRISPR screens recently developed for Toxoplasma gondii to discover sensitizing and desensitizing mutations.

Dispensable Role of Mitochondrial Fission Protein 1 (Fis1) in the Erythrocytic Development of Plasmodium falciparum

September 24, 2020 - 14:01 -- Open Access
Author(s): 
Maruthi M, Ling L, Zhou J, Ke H
Reference: 
mSphere. 2020 Sep 23;5(5):e00579-20

Malaria remains a huge global health burden, and control of this disease has run into a severe bottleneck. To defeat malaria and reach the goal of eradication, a deep understanding of the parasite biology is urgently needed. The mitochondrion of the malaria parasite is essential throughout the parasite's life cycle and has been validated as a clinical drug target. In the asexual development of Plasmodium spp., the single mitochondrion grows from a small tubular structure to a complex branched network.

NOT Open Access | Gene editing reveals obligate and modulatory components of the CO(2) receptor complex in the malaria vector mosquito, Anopheles coluzzii

September 24, 2020 - 08:17 -- NOT Open Access
Author(s): 
Liu F, Ye Z, Baker A, Sun H, Zwiebel LJ
Reference: 
Insect Biochem Mol Biol. 2020 Sep 20:103470

The sensitivity to volatile carbon dioxide (CO2) produced by humans and other animals is a critical component in the host preference behaviors of the malaria vector mosquito Anopheles coluzzii. The molecular receptors responsible for the ability to sense CO2 are encoded by three putative gustatory receptor (Gr) genes (Gr22,23,24) which are expressed in a distinctive array of sensory neurons housed in maxillary palp capitate peg sensilla of An. coluzzii.

NOT Open Access | The malaria metabolite HMBPP does not trigger erythrocyte terpene release

September 24, 2020 - 08:13 -- NOT Open Access
Author(s): 
Miller JJ, Odom John A
Reference: 
ACS Infect Dis. 2020 Sep 23

Infection with malarial parasites renders hosts more mosquito attractive than their uninfected, healthy, counterparts. One volatile organic compound, α-pinene, is associated with <I>Plasmodium</i> spp. infection in multiple studies and is a known mosquito attractant.

Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

September 24, 2020 - 08:09 -- Open Access
Author(s): 
Kotepui M, Kotepui KU, Milanez GJ, Masangkay FR
Reference: 
Infect Dis Poverty. 2020 Sep 22;9(1):134.

Co-infection with both Plasmodium and dengue virus (DENV) infectious species could have serious and fatal outcomes if left undiagnosed and without timely treatment. The present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection, the risk of severe diseases due to co-infection, and to describe the complications of severe malaria and severe dengue among patients with co-infection.

Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests

September 24, 2020 - 08:07 -- Open Access
Author(s): 
André Barembaye Sagna, Mohammad Golam Kibria, Shamsun Naher, Shayla Islam, M. M. Aktaruzzaman, Mohammad Shafiul Alam and Cristian Koepfli
Reference: 
Malaria Journal 2020 19:345, 23 September 2020

Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests (RDTs), used by national malaria control and elimination programs for clinical diagnosis, present a valuable, yet rarely used resource for in-depth studies on malaria epidemiology.

Impact of sugarcane irrigation on malaria vector Anopheles mosquito fauna, abundance and seasonality in Arjo-Didessa, Ethiopia

September 24, 2020 - 08:06 -- Open Access
Author(s): 
Assalif Demissew, Dawit Hawaria, Solomon Kibret, Abebe Animut, Arega Tsegaye, Ming-Cheih Lee, Guiyun Yan and Delenasaw Yewhalaw
Reference: 
Malaria Journal 2020 19:344, 22 September 2020

Despite extensive irrigation development in Ethiopia, limited studies assessed the impact of irrigation on malaria vector mosquito composition, abundance and seasonality. This study aimed to evaluate the impact of sugarcane irrigation on species composition, abundance and seasonality of malaria vectors.

Evaluating effectiveness of screening house eaves as a potential intervention for reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya

September 24, 2020 - 08:04 -- Open Access
Author(s): 
Peter Njoroge Ng’ang’a, Collins Okoyo, Charles Mbogo and Clifford Maina Mutero
Reference: 
Malaria Journal 2020 19:341, 19 September 2020

Mosquito-proofing of houses using wire mesh screens is gaining greater recognition as a practical intervention for reducing exposure to malaria transmitting mosquitoes. Screening potentially protects all persons sleeping inside the house against transmission of mosquito-borne diseases indoors. The study assessed the effectiveness of house eaves screening in reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya.

Estimating Annual Fluctuations in Malaria Transmission Intensity and in the Use of Malaria Control Interventions in Five Sub-Saharan African Countries

September 23, 2020 - 09:34 -- Open Access
Author(s): 
Rts S Epidemiology Epi-Mal-Study Group, Adeniji E, Asante KP, Wéry S, et al.
Reference: 
Am J Trop Med Hyg. 2020 Sep 21

RTS,S/AS01E malaria vaccine safety, effectiveness, and impact will be assessed in pre- and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinated children. Because those comparisons may be confounded by potential year-to-year fluctuations in malaria transmission intensity and malaria control intervention usage, the latter should be carefully monitored to adequately adjust the analyses.

Pages

Subscribe to RSS - malaria