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NOT Open Access | Epidemiology and clinical outcomes of severe Plasmodium vivax malaria in India

April 14, 2021 - 16:56 -- NOT Open Access
Author(s): 
Foko LPK, Arya A, Sharma A, Singh V
Reference: 
J Infect. 2021 Apr 5:S0163-4453(21)00161-4

A systematic review and meta-analysis (SR-MA) of the available Indian literature on severe vivax malaria (SVM) was undertaken.

Efficacy and safety of artemisinin-based combination therapies for the treatment of uncomplicated malaria in pediatrics: a systematic review and meta-analysis

April 14, 2021 - 16:50 -- Open Access
Author(s): 
Shibeshi W, Alemkere G, Mulu A, Engidawork E
Reference: 
BMC Infect Dis. 2021 Apr 7;21(1):326

Malaria is a major cause of morbidity and mortality in pediatrics in malaria endemic areas. Artemisinin-based combination therapies (ACTs) are the drugs of choice for malaria management particularly across malaria-endemic countries. This systematic review and meta-analysis was performed to assess efficacy and safety of ACTs for uncomplicated malaria in pediatric populations.

Larval habitat diversity and Anopheles mosquito species distribution in different ecological zones in Ghana

April 14, 2021 - 16:47 -- Open Access
Author(s): 
Hinne IA, Attah SK, Mensah BA, Forson AO, Afrane YA
Reference: 
Parasit Vectors. 2021 Apr 7;14(1):193

Understanding the ecology of larval malaria and lymphatic filariasis mosquitoes in a changing environment is important in developing effective control tools or programmes. This study characterized the breeding habitats of Anopheles mosquitoes in rural communities in different ecological zones in Ghana during the dry and rainy seasons.

Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

April 14, 2021 - 16:43 -- Open Access
Author(s): 
Kosiyo P, Otieno W, Gitaka J, Munde EO, Ouma C
Reference: 
BMC Infect Dis. 2021 Apr 7;21(1):329Background

In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these haematological changes during infection. However, the contributions of the carriage of different HBB genotypes on these changes remain largely unknown.

An evaluation of repellency and feeding inhibition of ethno-medicinal plants against major malaria vectors in southern Ethiopia

April 14, 2021 - 16:37 -- Open Access
Author(s): 
Olbamo T, Esayas E, Gebre T, Massebo F
Reference: 
Parasit Vectors. 2021 Apr 7;14(1):190

Plant-based mosquito control methods may use as a supplementary malaria vector control strategy. This study aimed to evaluate the effect of smoking ethno-medicinal plants on indoor density and feeding activity of malaria vectors at early hours of the night and its residual effect after midnight in southern Ethiopia.

Detection of malaria parasites in samples from returning US travelers using the Alethia Malaria Plus LAMP assay

April 14, 2021 - 16:33 -- Open Access
Author(s): 
Ljolje D, Abdallah R, Lucchi NW
Reference: 
BMC Res Notes. 2021 Apr 7;14(1):128

In this study, the performance of a commercially available malaria LAMP assay (Alethia® Malaria Plus LAMP) was evaluated using retrospective clinical samples obtained from travelers returning to the United States of America (USA). Recently, several laboratories in non-malaria endemic countries evaluated the use of the loop mediated isothermal amplification (LAMP) assays for the diagnosis of imported malaria cases. These tests are simpler than polymerase-chain reaction (PCR)-based assays and were shown to have high sensitivity. Much of malaria diagnoses in the USA, is undertaken at the state level using mainly microscopy and rapid diagnostic tests (RDTs). However, molecular tools offer greater sensitivity over microscopy and RDTs. A reliable, easy to perform molecular assay can provide a test of choice for the accurate detection of malaria parasites in places where expert microscopy is lacking and/or for the detection of low-parasite density infections.

Clustering and Erratic Movement Patterns of Syringe-Injected versus Mosquito-Inoculated Malaria Sporozoites Underlie Decreased Infectivity

April 14, 2021 - 16:29 -- Open Access
Author(s): 
de Korne CM, Winkel BMF, Roestenberg M, et al.
Reference: 
mSphere. 2021 Apr 7;6(2):e00218-21

Malaria vaccine candidates based on live, attenuated sporozoites have led to high levels of protection. However, their efficacy critically depends on the sporozoites' ability to reach and infect the host liver. Administration via mosquito inoculation is by far the most potent method for inducing immunity but highly impractical. Here, we observed that intradermal syringe-injected Plasmodium berghei sporozoites (syrSPZ) were 3-fold less efficient in migrating to and infecting mouse liver than mosquito-inoculated sporozoites (msqSPZ).

Advances and opportunities in malaria population genomics

April 14, 2021 - 08:23 -- Open Access
Author(s): 
Neafsey DE, Taylor AR, MacInnis BL
Reference: 
Nat Rev Genet. 2021 Apr 8:1-16

Almost 20 years have passed since the first reference genome assemblies were published for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the most important mosquito vector of malaria in sub-Saharan Africa. Reference genomes now exist for all human malaria parasites and nearly half of the ~40 important vectors around the world.

Malaria infection is common and associated with perinatal mortality and preterm delivery despite widespread use of chemoprevention in Mali: an observational study 2010 to 2014

April 14, 2021 - 08:22 -- Open Access
Author(s): 
Mahamar A, Andemel N, Fried M, et al.
Reference: 
Clin Infect Dis. 2021 Apr 13:ciab301

In malaria-endemic areas, pregnant women and especially first-time mothers are more susceptible to Plasmodium falciparum. Malaria diagnosis is often missed during pregnancy, since many women with placental malaria remain asymptomatic or have submicroscopic parasitemia, masking the association between malaria and pregnancy outcomes Severe maternal anemia and low birthweight deliveries are well-established sequelae, but few studies have confirmed the relationship between malaria infection and severe outcomes like perinatal mortality in high transmission zones.

NOT Open Access | Artificial Intelligence Applied to the Rapid Identification of New Antimalarial Candidates with Dual-Stage Activity

April 14, 2021 - 08:19 -- NOT Open Access
Author(s): 
Lima MNN, Borba JVB, Andrade CH, et al.
Reference: 
ChemMedChem. 2021 Apr 8;16(7):1093-1103

Increasing reports of multidrug-resistant malaria parasites urge the discovery of new effective drugs with different chemical scaffolds. Protein kinases play a key role in many cellular processes such as signal transduction and cell division, making them interesting targets in many diseases. Protein kinase 7 (PK7) is an orphan kinase from the Plasmodium genus, essential for the sporogonic cycle of these parasites.

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