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Not Open Access | A 6.5kb intergenic structural variation enhances P450-mediated resistance to pyrethroids in malaria vectors lowering bed net efficacy

September 29, 2020 - 13:15 -- NOT Open Access
Mugenzi LMJ, Menze BD, Wondji CS, et al.
Mol Ecol. 2020 Sep 24

Elucidating the complex evolutionary armory that mosquitoes deploy against insecticides is crucial to maintain the effectiveness of insecticide-based interventions. Here, we deciphered the role of a 6.5kb structural variation (SV) in driving cytochrome P450-mediated pyrethroid resistance in the malaria vector, Anopheles funestus. Whole-genome pooled sequencing detected an intergenic 6.5kb SV between duplicated CYP6P9a/b P450s in pyrethroid-resistant mosquitoes through a translocation event.

Influence of GST- and P450-based metabolic resistance to pyrethroids on blood feeding in the major African malaria vector Anopheles funestus

September 22, 2020 - 10:33 -- Open Access
Nouage L, Elanga-Ndille E, Binyang A, Tchouakui M, Atsatse T, Ndo C, Kekeunou S, Wondji CS
PLoS One. 2020 Sep 18;15(9):e0230984

Insecticide resistance genes are often associated with pleiotropic effects on various mosquito life-history traits. However, very little information is available on the impact of insecticide resistance on blood feeding process in mosquitoes. Here, using two recently detected DNA-based metabolic markers in the major malaria vector, An. funestus, we investigated how metabolic resistance genes could affect the blood meal intake.

Erratum: "Prenatal Exposure to DDT and Pyrethroids for Malaria Control and Child Neurodevelopment: The VHEMBE Cohort, South Africa"

March 18, 2020 - 14:40 -- Open Access
Eskenazi B, An S, Rauch SA, Coker ES, Maphula A, Obida M, Crause M, Kogut KR, Bornman R, Chevrier J
Environ Health Perspect. 2020 Mar;128(3):39001

In this article, pyrethroid metabolite measurements were reported to be specific gravity-corrected. However, the statistical analyses were completed with uncorrected pyrethroid metabolite measurements. The results using specific gravity-corrected metabolite measurements are largely consistent with the uncorrected analyses.

NOT Open Access | A sensory appendage protein protects malaria vectors from pyrethroids

January 15, 2020 - 09:05 -- NOT Open Access
Ingham VA, Anthousi A, Douris V, Harding NJ, Lycett G, Morris M, Vontas J, Ranson H
Nature volume 577, pages376–380(2020)

Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated morbidity and mortality in Africa since the beginning of the century1. The intense selection pressure exerted by bed nets has precipitated widespread and escalating resistance to pyrethroids in African Anopheles populations, threatening to reverse the gains that been made by malaria control2. Here we show that expression of a sensory appendage protein (SAP2), which is enriched in the legs, confers pyrethroid resistance to Anopheles gambiae.

Insecticidal and repellent activities of pyrethroids to the three major pyrethroid-resistant malaria vectors in western Kenya

May 9, 2014 - 17:51 -- Open Access
Kawada H, Ohashi K, Dida GO, Sonye G, Njenga SM, Mwandawiro C, Minakawa N
Parasites & Vectors 2014, 7 :208 (2 May 2014)

Adult susceptibility tests were performed using World Health Organization (WHO) test tube kits for F1 progenies of field-collected An. gambiae s.s., An. arabiensis, and An. funestus s.s., and laboratory colonies of An. gambiae s.s. and An. arabiensis.

An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission

April 16, 2014 - 18:34 -- Open Access
Ogoma SB, Lorenz LM, Moore SJ, et al.
Malaria Journal 2014, 13 :131 (1 April 2014)

This study highlights that airborne pyrethroids and DDT affect a range of anopheline mosquito behaviours that are important parameters in malaria transmission, namely deterrence, irritancy/excito-repellency and blood-feeding inhibition.

Is the bednet era coming to an end?

June 22, 2012 - 12:47 -- Bart G.J. Knols

Whenever I teach on the history of malaria, I talk about the different time periods when certain ideas were fashionable and implemented, and then disappeared, and sometimes came back much later.

Take the 'chloroquine era'. Discovered by Bayer scientists in the early 1930s and saved millions of lives around the globe, followed by resistance popping up in SE Asia and Colombia in the late 1950s. Resistance spreading to Africa in the late 1970s, and its use now largely reduced. End of the 'chloroquine era'.

Waking up in the face of resistance?

July 7, 2011 - 15:54 -- Bart G.J. Knols

Sometimes you come across articles that blow your mind. You read them and feel your heartbeat increasing. Each sentence you finish makes you wonder more what is going on here. What the politics are, who's really behind it, and what the goal of it is....

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