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Cambodia

Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia

March 30, 2020 - 10:11 -- Open Access
Author(s): 
Roesch C, Mairet-Khedim M, Kim S, Lek D, Popovici J, Witkowski B
Reference: 
J Antimicrob Chemother. 2020 Mar 24. pii: dkaa092

Cambodia is the epicentre of the emergence of Plasmodium falciparum drug resistance. Much less is known regarding the drug susceptibility of the co-endemic Plasmodium vivax. Only in vitro drug assays can determine the parasite’s intrinsic susceptibility, but these are challenging to implement for P. vivax and rarely performed.

Significant efficacy of single low dose primaquine compared to stand alone artemisinin combination therapy in reducing gametocyte carriage in Cambodian patients with uncomplicated multidrug resistant Plasmodium falciparum malaria

March 19, 2020 - 09:13 -- Open Access
Author(s): 
Vantaux A, Kim S, Piv E, Chy S, Berne L, Khim N, Lek D, Siv S, Mukaka M, Taylor WR, Ménard D
Reference: 
Antimicrob Agents Chemother. 2020 Mar 16. pii: AAC.02108-19

Since 2012, single low dose of primaquine (SLDPQ, 0.25mg/kg) has been recommended with artemisinin-based combination therapies, as first-line treatment of acute uncomplicated Plasmodium falciparum malaria, to interrupt its transmission, especially in low transmission settings of multidrug, including artemisinin, resistance. Policy makers in Cambodia have been reluctant to implement this recommendation due to primaquine safety concerns and lack of data on its efficacy.

Corrigendum to: Hemolytic Dynamics of Weekly Primaquine Antirelapse Therapy Among Cambodians With Acute Plasmodium vivax Malaria With or Without Glucose-6-Phosphate Dehydrogenase Deficiency

February 22, 2020 - 17:12 -- Open Access
Author(s): 
Taylor WRJ, Kheng S, Muth S, Tor P, Kim S, Bjorge S, Topps N, Kosal K, Sothea K, Souy P, Char CM, Vanna C, Ly P, Khieu V, Christophel E, Kerleguer A, Pantaleo A, Mukaka M, Menard D, Baird JK
Reference: 
The Journal of Infectious Diseases, Volume 221, Issue 5, 1 March 2020, Page 854

In “Hemolytic Dynamics of Weekly Primaquine Antirelapse Therapy Among Cambodians With Acute Plasmodium vivax Malaria With or Without Glucose-6-Phosphate Dehydrogenase Deficiency” by Taylor et al [J Infect Dis 2019; 220(11): 1750–60], P values should be P < 0.001 where 0.000 is written. This has been updated in the article.

The authors regret these errors.

The probability of a sequential Plasmodium vivax infection following asymptomatic Plasmodium falciparum and P. vivax infections in Myanmar, Vietnam, Cambodia, and Laos

January 6, 2020 - 16:21 -- Open Access
Author(s): 
Lorenz von Seidlein, Pimnara Peerawaranun, Arjen M. Dondorp, et al.
Reference: 
Malaria Journal 2019 18:449, 30 December 2019

Adding 8-aminoquinoline to the treatment of falciparum, in addition to vivax malaria, in locations where infections with both species are prevalent could prevent vivax reactivation. The potential risk of haemolysis under a universal radical cure policy using 8-aminoquinoline needs to be weighed against the benefit of preventing repeated vivax episodes. Estimating the frequency of sequential Plasmodium vivax infections following either falciparum or vivax malaria episodes is needed for such an assessment.

Rubber plantations and drug resistant malaria: a cross-sectional survey in Cambodia

December 3, 2019 - 15:26 -- Open Access
Author(s): 
Rebecca Thomson, Phok Sochea, Mak Sarath, Amanda MacDonald, Abigail Pratt, Steve Poyer, Henrietta Allen, Sok Kunthy, Sok Chamroeun, Kim Daro, Sourn Samean, Nou Panharith, Sok Ra, Chan Sovottha, Gary Mundy and Shunmay Yeung
Reference: 
Malaria Journal 2019 18:379, 27 November 2019

The ongoing spread of artemisinin resistant Plasmodium falciparum malaria is a major threat to global health. In response, countries in the Greater Mekong Sub-region, including Cambodia, have declared ambitious goals to eliminate malaria. Major challenges include the lack of information on the at-risk population-individuals who live or work in or near the forest where the malaria vectors are found, including plantation workers. This study aimed to address this knowledge gap through a cross-sectional survey conducted in rubber plantations in Cambodia in 2014.

Towards malaria elimination: innovative tools for malaria surveillance in Cambodia

January 24, 2014 - 16:56 -- MESA Alliance

The Malaria Consortium has published ‘Moving towards malaria elimination: developing innovative tools for malaria surveillance in Cambodia‘ as part of their ‘Learning Paper’ series. 

ACTs: What will happen when the cat gets out of the bag?

April 11, 2011 - 20:47 -- Bart G.J. Knols

Most of us that have worked in the field of malaria for a few decades have gone through periods where we suddenly noticed changes in drug policy. When chloroquine was replaced by sulfadoxine-pyremethamine as a first-line drug, later to be replaced by artemisinin combination therapies (ACTs).

But the world is now faced with a new challenge. That of preventing artemisinin resistance from escaping south-east Asia. Without anything to replace it (yet), this is a looming catastrophe, according to Joel Breman in an interview with TropIKA.net. It may still be confined to the Thai-Cambodia border, although nobody really nows have far it has spread.

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