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Cameroon

Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998–2020)

January 13, 2021 - 10:01 -- Open Access
Author(s): 
Peter Thelma Ngwa Niba, Akindeh M. Nji, Wilfred F. Mbacham, et al.
Reference: 
Malaria Journal 2021 20:32, 9 January 2021

Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon from January 1998 to August 2020.

Preliminary validation of the use of IgG antibody response to Anopheles gSG6-p1 salivary peptide to assess human exposure to malaria vector bites in two endemic areas of Cameroon in Central Africa

January 6, 2021 - 13:01 -- Open Access
Author(s): 
Cheteug G, Elanga-Ndille E, Donkeu C, Ekoko W, Oloume M, Essangui E, Nwane P, NSango SE, Etang J, Wanji S, Ayong L, Eboumbou Moukoko CE
Reference: 
PLoS One. 2020 Dec 31;15(12):e0242510

The specific immune response to the Anopheles salivary peptide could be a pertinent and complementary tool to assess the risk of malaria transmission and the effectiveness of vector control strategies. This study aimed to obtain first reliable data on the current state of the Anopheles gSG6-P1 biomarker for assess the level of exposure to Anopheles bites in high malaria endemic areas in Cameroon.

NOT Open Access | Investigation of Dengue-Malaria co-infection among febrile patients consulting at Ngaoundere Regional Hospital, Cameroon

December 16, 2020 - 12:51 -- NOT Open Access
Author(s): 
Galani BRT, Mapouokam DW, Nemg Simo FB, Mohamadou H, Djamen Chuisseu PD, Njintang NY, Moundipa PF
Reference: 
J Med Virol. 2020 Dec 15

This study aimed at evaluating the seroprevalence of dengue among malarious patients consulting at the Ngaoundere regional hospital. During 2 months and a half, 174 participants were recruited and their blood samples were screened for Plasmodium spp and then for Dengue virus (DENV) infection using rapid diagnostic tests. Also, hematological parameters were measured using a hematology autoanalyzer. Among patients tested, 134 (77.01%) were malaria-positive, and 12/134 (8.95%) were co-infected. In this population, 8/12 (66.67%) were only anti-DENV IgM-positive, 3/12 (25%) were both NS1 and anti-DENV IgM positive, and 1/12 (8.33%) were anti-DENV IgG-positive.

Severe malaria in Cameroon: Pattern of disease in children at the Yaounde Gynaeco-Obstetric and Pediatric hospital

October 7, 2020 - 16:07 -- Open Access
Author(s): 
Chiabi A, Djimafo ANM, Nguefack S, Mah E, Nguefack Dongmo F, Angwafo F 3rd
Reference: 
J Infect Public Health. 2020 Oct;13(10):1469-1472

Malaria is the most widely spread parasitic disease in the world, especially in the tropics affecting mostly children and pregnant women. In children, mostly under-fives carry the heaviest burden in terms of morbidity and mortality. The aim of this study was to determine the epidemiological and clinical aspects, and outcome of children 3 months to 15 years old with severe malaria at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH), a referral hospital in Yaounde, Cameroon.

NOT Open Access | Malaria fighters' latest chemical weapon may not last long

September 8, 2020 - 11:56 -- NOT Open Access
Author(s): 
Makoni M
Reference: 
Science. 2020 Sep 4;369(6508):1153

Two years ago, the World Health Organization (WHO) gave the green light for clothianidin, long used to kill crop pests, to be added to the current mainstays of indoor mosquito control, which are losing their effectiveness as the insects develop resistance.

Antibodies to full-length and the DBL5 domain of VAR2CSA in pregnant women after long-term implementation of intermittent preventive treatment in Etoudi, Cameroon

August 18, 2020 - 14:55 -- Open Access
Author(s): 
Djontu JC, Lloyd YM, Megnekou R, Seumko'o RMN, Salanti A, Taylor DW, Leke RGF
Reference: 
PLoS ONE 15(8): e0237671

In high malaria transmission settings, the use of sulfadoxine-pyrimethamine-based intermittent preventive treatment during pregnancy (IPTp-SP) has resulted in decreased antibody (Ab) levels to VAR2CSA. However, information of Ab levels in areas of low or intermediate malaria transmission after long-term implementation of IPTp-SP is still lacking. The present study sought to evaluate antibody prevalence and levels in women at delivery in Etoudi, a peri-urban area in the capital of Yaoundé, Cameroon, that is a relatively low-malaria transmission area.

NOT Open Access | Malaria in the third trimester and maternal-perinatal outcome

June 9, 2020 - 11:41 -- NOT Open Access
Author(s): 
Nkwabong E, Mayane DN, Meka E, Essiben F
Reference: 
Int J Gynaecol Obstet. 2020 Jun 8

To evaluate maternal and perinatal outcomes in cases of third-trimester malaria (TTM).

The effect of improved housing on indoor mosquito density and exposure to malaria in the rural community of Minkoameyos, Centre Region of Cameroon

May 6, 2020 - 15:06 -- Open Access
Author(s): 
Rachel L. Nguela, Jude D. Bigoga, Rose G. F. Leke, et al.
Reference: 
Malaria Journal 2020 19:172, 3 May 2020

This study evaluated the effectiveness of improved housing on indoor residual mosquito density and exposure to infected Anophelines in Minkoameyos, a rural community in southern forested Cameroon.

Severe malaria in Cameroon: Pattern of disease in children at the Yaounde Gynaeco-Obstetric and Pediatric hospital

May 5, 2020 - 13:11 -- Open Access
Author(s): 
Chiabi A, Djimafo ANM, Nguefack S, Mah E, Nguefack Dongmo F, Angwafo F
Reference: 
J Infect Public Health. 2020 Apr 29. pii: S1876-0341(20)30393-2

Malaria is the most widely spread parasitic disease in the world, especially in the tropics affecting mostly children and pregnant women. In children, mostly under-fives carry the heaviest burden in terms of morbidity and mortality. The aim of this study was to determine the epidemiological and clinical aspects, and outcome of children 3 months to 15 years old with severe malaria at the Yaounde Gynaeco-Obstetric and Pediatric Hospital (YGOPH), a referral hospital in Yaounde, Cameroon.

Influence of malaria, soil-transmitted helminths and malnutrition on haemoglobin level among school-aged children in Muyuka, Southwest Cameroon: A cross-sectional study on outcomes

April 6, 2020 - 08:02 -- Open Access
Author(s): 
Sumbele IUN, Nkain AJ, Ning TR, Anchang-Kimbi JK, Kimbi HK
Reference: 
PLoS One. 2020 Mar 30;15(3):e0230882

The health of school-aged children (SAC) is often compromised by malaria parasitaemia (MP), soil-transmitted helminths (STH), and malnutrition in the tropics. The aim of this study was to determine the prevalence and influence of MP, STH and malnutrition on haemoglobin (Hb) levels as well as identify its predictors.

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