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Artemisinin combination therapy mass drug administration in a setting of low malaria endemicity: programmatic coverage and adherence during an observational study in Zanzibar

August 15, 2017 - 14:38 -- Open Access
Abdullah S. Ali, Narjis G. Thawer, Bakar Khatib, Haji H. Amier, Joseph Shija, Mwinyi Msellem, Abdul-wahid Al-mafazy, Issa A. Garimo, Humphrey Mkali, Mahdi M. Ramsan, Jessica M. Kafuko, Lynn A. Paxton, Richard Reithinger and Jeremiah M. Ngondi
Malaria Journal 2017 16:332, 14 August 2017

Mass drug administration for malaria was well accepted by communities at high risk of malaria in Zanzibar, with high participation and completion rates.

Artemisinin Combination Therapy: A Good Antimalarial, but Is the Dose Right?

December 10, 2013 - 06:52 -- Open Access
Paul Garner
PLoS Med 10(12): e1001565

Artemisinin combination therapy (ACT) has revolutionised malaria treatment. ACTs combine an artemisinin derivative (a relatively new group of very effective drugs  with another longer-lasting drug from another class to try to reduce the risk of further resistance developing. ACTs cure over 90% of people; they also act against malaria gametocytes, so potentially reduce transmission.

Methods for implementing a medicine outlet survey: lessons from the anti-malarial market

February 11, 2013 - 15:37 -- Open Access
O'Connell KA, Poyer S, Solomon T, Munroe E, Patouillard E, Njogu J, Evance I, Hanson K, Shewchuk T, Goodman C
Malaria Journal 2013, 12:52 (5 February 2013)

The paper concludes with advice on practical considerations, including questionnaire design, field worker training, and data collection. Survey materials developed by ACTwatch for investigating anti-malarial markets in sub-Saharan Africa and Asia provide a helpful resource for future studies in this area.

Not Open Access | Transitioning from malaria control to elimination: the vital role of ACTs

February 5, 2013 - 16:14 -- NOT Open Access
Heiner Grueninger, Kamal Hamed
Trends in Parasitology, Volume 29, Issue 2, February 2013, Pages 60-64

In this opinion paper, the requirements for the continued success of ACTs, their role in this transition, and possible new ways of using these drugs in an elimination setting are discussed. ACTs have an important role to play in maintaining the current success of control programs, and may also drive these successes forward into the widespread elimination of malaria.

Free Book for MalariaWorld Members!

November 27, 2012 - 21:45 -- Bart G.J. Knols

This week I was contacted by Dr. Dana Dalrymple with a very unusual offer. He wishes to provide all MalariaWorld subscribers free access to his book 'Artemisia annua, Artemisinin, ACTs & Malaria Control in Africa' published just seven months ago. This is truly remarkable and we highly appreciate this gesture!

In his email he said: "This will get it to the heart of the international malaria community and doubtless reach many who otherwise may not have heard of, or had access to, it." That is the spirit of truly open and global collaboration we aim to achieve with MalariaWorld. So a big 'Thank you' to Dr. Dalrymple! If you download it, why not send him a private message through the platform (available to subcribers) to let him know you appreciate his action...

ACTs: What will happen when the cat gets out of the bag?

April 11, 2011 - 20:47 -- Bart G.J. Knols

Most of us that have worked in the field of malaria for a few decades have gone through periods where we suddenly noticed changes in drug policy. When chloroquine was replaced by sulfadoxine-pyremethamine as a first-line drug, later to be replaced by artemisinin combination therapies (ACTs).

But the world is now faced with a new challenge. That of preventing artemisinin resistance from escaping south-east Asia. Without anything to replace it (yet), this is a looming catastrophe, according to Joel Breman in an interview with It may still be confined to the Thai-Cambodia border, although nobody really nows have far it has spread.

Price Subsidy Schemes for Artemisinin-Based Combination Therapies (ACTs): Do They Work?

April 5, 2011 - 19:26 -- The Global Heal...

Although ACTs are recommended as first line treatment for uncomplicated malaria, actual use of ACT is very limited, partly due to its high price in pharmacies and retail stores. The Affordable Medicines Facility-malaria (AMFm), a donor-funded global price subsidy, has been proposed as a strategy to increase ACT use in malaria-endemic countries. Given that donor-supported ACT subsidy schemes are costly, it is crucial to ensure that they have their intended impact.

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