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knowlesi

Efficient synchronization of Plasmodium knowlesi in vitro cultures using guanidine hydrochloride

April 29, 2019 - 13:17 -- Open Access
Author(s): 
Sutharinee Ngernna, Anongruk Chim-ong, Wanlapa Roobsoong, Jetsumon Sattabongkot, Liwang Cui and Wang Nguitragool
Reference: 
Malaria Journal 2019 18:148, 25 April 2019

Long-term in vitro culture of blood stage Plasmodium parasites invariably leads to asynchronous parasite development. The most often used technique to synchronize Plasmodium falciparum culture is sorbitol treatment, which differentially induces osmotic lysis of trophozoite- and schizont-infected red blood cells due to presence of the new permeation pathways in the membranes of these cells. However, sorbitol treatment does not work well when used to synchronize the culture-adapted Plasmodium knowlesi A1-H.1 line.

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Plasmodium knowlesi and other malaria parasites in long-tailed macaques from the Philippines

April 29, 2019 - 13:15 -- Open Access
Author(s): 
Lief Erikson Gamalo, Judeline Dimalibot, Khamisah Abdul Kadir, Balbir Singh and Vachel Gay Paller
Reference: 
Malaria Journal 2019 18:147, 24 April 2019

Macaca fascicularis (long-tailed macaque) is the most widespread species of macaque in Southeast Asia and the only species of monkey found naturally in the Philippines. The species is the natural host for the zoonotic malaria species, Plasmodium knowlesi and Plasmodium cynomolgi and for the potentially zoonotic species, Plasmodium inui. Moreover, other Plasmodium species such as Plasmodium coatneyi and Plasmodium fieldi are also natural parasites of M. fascicularis. The aims of this study were to identify and determine the prevalence of Plasmodium species infecting wild and captive long-tailed macaques from the Philippines.

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The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes

August 15, 2017 - 14:35 -- Open Access
Author(s): 
Khai Lone Lim, Amirah Amir, Yee Ling Lau and Mun Yik Fong
Reference: 
Malaria Journal 2017 16:331, 11 August 2017

This study is the first report of phenotypic difference between PkDBPαII haplotypes.

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