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Integrity, use and care of long-lasting insecticidal nets in Kirinyaga County, Kenya

May 5, 2021 - 10:35 -- Open Access
Nyangi M, Kigondu E, Irungu B, Nganga M, Gachanja A, Murigi M, Nyangacha R, Muniu E, Kamau L, Gathirwa J
BMC Public Health. 2021 May 3;21(1):856

Vector control is an essential component in prevention and control of malaria in malaria endemic areas. Insecticide treated nets is one of the standard tools recommended for malaria vector control. The objective of the study was to determine physical integrity and insecticidal potency of long-lasting insecticidal nets (LLINs) used in control of malaria vector in Kirinyaga County, Kenya.

Entomological and Anthropological Factors Contributing to Persistent Malaria Transmission in Kenya, Ethiopia, and Cameroon

April 29, 2021 - 08:23 -- Open Access
Bamou R, Rono M, Mwangangi J, et al.
J Infect Dis. 2021 Apr 27;223(Supplement_2):S155-S170

In order to improve our understanding of the fundamental limits of core interventions and guide efforts based on prioritization and identification of effective/novel interventions with great potentials to interrupt persistent malaria transmission in the context of high vector control coverage, the drivers of persistent disease transmission were investigated in three eco-epidemiological settings; forested areas in Cameroon, coastal area in Kenya and highland areas in Ethiopia.

NOT Open Access | Exposure to diverse Plasmodium falciparum genotypes shapes the risk of symptomatic malaria in incident and persistent infections: A longitudinal molecular epidemiologic study in Kenya

April 29, 2021 - 07:56 -- NOT Open Access
Sumner KM, Freedman E, Taylor SM, et al.
Clin Infect Dis. 2021 Apr 27:ciab357

Repeated exposure to malaria infections could protect against symptomatic progression, as people develop adaptive immunity to infections acquired over time.

Insecticide resistance status in Anopheles gambiae (s.l.) in coastal Kenya

April 22, 2021 - 08:26 -- Open Access
Munywoki DN, Kokwaro ED, Mwangangi JM, Muturi EJ, Mbogo CM
Parasit Vectors. 2021 Apr 20;14(1):207

The rapid and widespread evolution of insecticide resistance has emerged as one of the major challenges facing malaria control programs in sub-Saharan Africa. Understanding the insecticide resistance status of mosquito populations and the underlying mechanisms of insecticide resistance can inform the development of effective and site-specific strategies for resistance prevention and management. The aim of this study was to investigate the insecticide resistance status of Anopheles gambiae (s.l.) mosquitoes from coastal Kenya.

IFN-λ4 genetic variants influence clinical malaria episodes in a cohort of Kenyan children

April 21, 2021 - 15:23 -- Open Access
Gabriela Samayoa-Reyes, Conner Jackson, Sidney Ogolla, Katherine Sabourin, Adeola Obajemu, Arlene E. Dent, Ludmilla Prokunina-Olsson and Rosemary Rochford
Malaria Journal 2021 20:196, 21 April 2021

Interferon (IFN)- λ4, a type III IFN, production is controlled by a dinucleotide frameshift variant (rs368234815-dG/TT) within the first exon of the IFNL4 gene. Carriers of the IFNL4-dG allele but not the IFNL4-TT allele are able to produce the IFN-λ4 protein. Patients with hepatitis C virus that do not produce the IFN-λ4 protein have higher rates of viral clearance suggesting a potential inhibitory role of IFN-λ4 in liver-tropic infections.

Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya

April 14, 2021 - 16:43 -- Open Access
Kosiyo P, Otieno W, Gitaka J, Munde EO, Ouma C
BMC Infect Dis. 2021 Apr 7;21(1):329Background

In Plasmodium falciparum infection, clinical conditions such as anaemia, thrombocytopenia and leukocytosis are common. Mutation in haemoglobin sub-unit beta gene (HBB) may be a genetic factor responsible for these haematological changes during infection. However, the contributions of the carriage of different HBB genotypes on these changes remain largely unknown.

A unified and flexible modelling framework for the analysis of malaria serology data

April 13, 2021 - 13:01 -- Open Access
Kyomuhangi I, Giorgi E
Epidemiol Infect. 2021 Apr 12:1-18

Current models for analysing malaria serology data are limited by the need to dichotomize continuous antibody measurements, as well as strict assumptions about malaria transmission dynamics. 

A retail audit of mosquito control products in Busia County, western Kenya

March 24, 2021 - 14:46 -- Open Access
Prisca A. Oria, Vincent Moshi, Julius I. Odero, Sheila Ekodir, April Monroe, Steven A. Harvey, Eric Ochomo and Danielle Piccinini Black
Malaria Journal 2021 20:163, 23 March 2021

Approximately 70% of Kenya’s population is at risk for malaria. The core vector control methods in Kenya are insecticide-treated mosquito nets (ITNs) and indoor residual spraying, with supplementary larval source management. In 2015, 21% of ITNs were accessed through the private retail sector. Despite the private sector role in supplying mosquito control products (MCPs), there is little evidence on the availability, sales trends, and consumer preferences for MCPs other than ITNs. This study, a component of a larger research programme focused on evaluating a spatial repellent intervention class for mosquito-borne disease control, addressed this evidence gap on the role of the private sector in supplying MCPs.

Strengthening community and stakeholder participation in the implementation of integrated vector management for malaria control in western Kenya: a case study

March 24, 2021 - 14:22 -- Open Access
Peter N. Ng’ang’a, Polycarp Aduogo and Clifford M. Mutero
Malaria Journal 2021 20:155, 19 March 2021

Integrated vector management (IVM) is defined as a rational decision-making process for the optimal use of resources for vector control. The IVM approach is based on the premise that effective control of vectors and the diseases they transmit is not the sole preserve of the health sector. It requires the collaboration and participation of communities and other stakeholders in public and private sectors. Community participation is key to the success of IVM implementation at the local level.

Insecticide resistance status of indoor and outdoor resting malaria vectors in a highland and lowland site in Western Kenya

March 2, 2021 - 15:19 -- Open Access
Owuor KO, Machani MG, Mukabana WR, Munga SO, Yan G, Ochomo E, Afrane YA
PLoS One. 2021 Mar 1;16(3):e0240771

Long Lasting Insecticidal Nets (LLINs) and indoor residual spraying (IRS) represent powerful tools for controlling malaria vectors in sub-Saharan Africa. The success of these interventions relies on their capability to inhibit indoor feeding and resting of malaria mosquitoes. This study sought to understand the interaction of insecticide resistance with indoor and outdoor resting behavioral responses of malaria vectors from Western Kenya.


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