The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10493 malaria professionals are enjoying the free benefits of MalariaWorld today

plasmodium falciparum parasites

Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda

February 22, 2020 - 16:49 -- Open Access
Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T. Katuro, Edward H. Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S. Obwoya, Denis A. Anywar, Mary A. Auma, Nirianne M. Q. Palacpac, Takafumi Tsuboi, Emmanuel I. Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii & Toshihiro Mita
Malaria Journal 2020 19:76, 18 February 2020

Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiological studies have demonstrated that the discontinuance led to re‑emergence of chloroquine‑susceptible P. falciparum, suggesting a possible role in future malaria control. However, most studies were cross‑sectional, with few studies looking at the persistence of chloroquine recovery in long term. This study fills the gap by providing, for a period of at least 6 years, proof of persistent re‑emergence/stable recovery of susceptible parasite populations using both molecular and phenotypic methods.

Not Open Access: Sporozoite Route of Infection Influences In Vitro var Gene Transcription of Plasmodium falciparum Parasites From Controlled Human Infections

August 26, 2016 - 15:16 -- NOT Open Access
Sandra Dimonte, Ellen I. Bruske, Matthias Frank, et al.
J Infect Dis. (2016) 214 (6): 884-894

Thirty malaria-naive individuals were inoculated by intradermal or intravenous injection with cryopreserved, isogenic NF54 P. falciparum sporozoites (PfSPZ) generated from 1 premosquito culture. Microscopic parasitemia developed in 22 individuals, and 21 in vitro cultures were established.

Subscribe to RSS - plasmodium falciparum parasites