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artemisinin; hypnozoite; malaria; merozoite; Plasmodium vivax; primaquine; relapse; ring stage; trophozoite

Plasmodium vivax: Drug-induced Dormancy?

May 12, 2016 - 13:28 -- Miles Markus

Early recurrences (which are often homologous) in treated Plasmodium vivax infections are usually considered to be hypnozoite-mediated relapses. Can such recurrences sometimes or frequently be, instead, recrudescences caused by reactivation of blood stages that became temporarily quiescent following drug exposure? The experimental background to this question is given here.

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