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hypnozoite; malaria; Plasmodium vivax; primaquine; relapse

Primaquine Not "Working"

May 5, 2016 - 14:02 -- Miles Markus

Therapeutic failure of primaquine in cases of Plasmodium vivax malaria is often noted by clinicians. A newly recognized, possible cause of such treatment failure is the reactivation of viable dormant parasites that might be present in one or more extra-hepatic and extra-vascular sites. Administration of primaquine will not necessarily result in these stages being killed. Here is the link to where this drug-associated matter is discussed.

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