The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10698 malaria professionals are enjoying the free benefits of MalariaWorld today

who

The Gini coefficient as a useful measure of malaria inequality among populations

December 3, 2020 - 12:38 -- Open Access
Author(s): 
Jonathan Abeles and David J. Conway
Reference: 
Malaria Journal 2020 19:444, 2 December 2020

Understanding inequality in infectious disease burden requires clear and unbiased indicators. The Gini coefficient, conventionally used as a macroeconomic descriptor of inequality, is potentially useful to quantify epidemiological heterogeneity. With a potential range from 0 (all populations equal) to 1 (populations having maximal differences), this coefficient is used here to show the extent and persistence of inequality of malaria infection burden at a wide variety of population levels.

Increased malaria parasitaemia among adults living with HIV who have discontinued cotrimoxazole prophylaxis in Kitgum district, Uganda

November 12, 2020 - 15:47 -- Open Access
Author(s): 
Orishaba P, Kalyango JN, Nankabirwa JI, et al.
Reference: 
PLoS One. 2020 Nov 11;15(11):e0240838

Although WHO recommends cotrimoxazole (CTX) discontinuation among HIV patients who have undergone immune recovery and are living in areas of low prevalence of malaria, some countries including Uganda recommend CTX discontinuation despite having a high malaria burden. We estimated the prevalence and factors associated with malaria parasitaemia among adults living with HIV attending hospital outpatient clinic before and after discontinuation of CTX prophylaxis.

Reactive Case Detection (RACD) and foci investigation strategies in malaria control and elimination: a review

November 11, 2020 - 14:25 -- Open Access
Author(s): 
Ruwanthi Perera, Amandhi Caldera and A. Rajitha Wickremasinghe
Reference: 
Malaria Journal 2020 19:401, 10 November 2020

Reactive case detection (RACD) and foci investigation are key strategies in malaria elimination and prevention of its re-establishment. They are a key part of surveillance that has been recommended by the World Health Organization (WHO) to be considered as a core intervention and as one of the three pillars of the Global Technical Strategy for Malaria 2016–2030.

Tenebenal: a meta-diamide with potential for use as a novel mode of action insecticide for public health

November 11, 2020 - 14:17 -- Open Access
Author(s): 
Rosemary Susan Lees, Pauline Ambrose, Jessica Williams, John Morgan, Giorgio Praulins, Victoria A. Ingham, Chris T. Williams, Rhiannon Agnes Ellis Logan, Hanafy M. Ismail and David Malone
Reference: 
Malaria Journal 2020 19:398, 10 November 2020

There is an urgent need for insecticides with novel modes of action against mosquito vectors. Broflanilide is a meta-diamide, discovered and named Tenebenal™ by Mitsui Chemicals Agro, Inc., which has been identified as a candidate insecticide for use in public health products.

NOT Open Access | Short Persistence and Vector Susceptibility to Ficam 80WP (bendiocarb active ingredient) During Pilot Application of Indoor Residual Spraying in Burkina Faso, West Africa

November 10, 2020 - 14:33 -- NOT Open Access
Author(s): 
Hien AS, Soma DD, Somé FA, Namountougou M, Poda SB, Ouédraogo GA, Diabaté A, Dabiré RK
Reference: 
J Med Entomol. 2020 Nov 9:tjaa240

Indoor residual spraying (IRS) was applied in addition to the use of long-lasting insecticidal nets in the South West in Burkina Faso, where Anopheles gambiae s.l. the major malaria vector was resistant to pyrethroids. This study was designed to evaluate the efficacy and residual life of bendiocarb (active ingredient) used for spraying on different wall surfaces (mud and cement).

Not Open Access | Phenotypic Insecticide Resistance in Anopheles gambiae (Diptera: Culicidae): Specific Characterization of Underlying Resistance Mechanisms Still Matters

October 13, 2020 - 12:56 -- NOT Open Access
Author(s): 
Medjigbodo AA, Djogbenou LS, Koumba AA, Djossou L, Badolo A, Adoha CJ, Ketoh GK, Mavoungou JF
Reference: 
J Med Entomol. 2020 Oct 12:tjaa195

An effective control of malaria vectors requires an extensive knowledge of mechanisms underlying the resistance-phenotypes developed by these vectors against insecticides. We investigated Anopheles gambiae mosquitoes from Benin and Togo for their intensity of insecticide resistance and we discussed the involvement of genotyped mechanisms in the resistance-phenotypes observed.

Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs

October 1, 2020 - 07:45 -- Open Access
Author(s): 
Saito M, Briand V, Min AM, McGready R
Reference: 
Lancet Child Adolesc Health. 2020 Oct;4(10):761-774

All malaria infections are harmful to both the pregnant mother and the developing fetus. One in ten maternal deaths in malaria endemic countries are estimated to result from Plasmodium falciparum infection. Malaria is associated with a 3-4 times increased risk of miscarriage and a substantially increased risk of stillbirth. Current treatment and prevention strategies reduce, but do not eliminate, malaria's damaging effects on pregnancy outcomes.

NOT Open Access | Integrating public health programs and research after the malaria vaccine implementation program (MVIP): Recommendations for next steps

September 30, 2020 - 11:45 -- NOT Open Access
Author(s): 
van der Graaf R, Macklin R, van Delden JJM, et al.
Reference: 
Vaccine. 2020 Sep 24:S0264-410X(20)31132-4

In February 2020, international controversy arose about the ethical acceptability of the WHO Malaria Vaccine Implementation Program (MVIP). Whereas some have argued that this program must be seen as research that is not in line with international ethical standards, notably regarding informed consent and local ethical review, some WHO representatives consider the MVIP as a public health implementation program that need not adhere to these standards.

Natural Products: A Potential Source of Malaria Transmission Blocking Drugs

September 23, 2020 - 09:00 -- Open Access
Author(s): 
Moyo P, Mugumbate G, Eloff JN, Louw AI, Maharaj VJ, Birkholtz LM
Reference: 
Pharmaceuticals (Basel). 2020 Sep 17;13(9):E251

The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but its use is severely restricted by toxicity in some populations. New, safe and clinically effective transmission-blocking drugs therefore need to be discovered.

Comparative functional survival and equivalent annual cost of 3 long-lasting insecticidal net (LLIN) products in Tanzania: A randomised trial with 3-year follow up

September 22, 2020 - 10:34 -- Open Access
Author(s): 
Lorenz LM, Bradley J, Moore SJ, et al.
Reference: 
PLoS Med. 2020 Sep 18;17(9):e1003248

Two billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. A functional LLIN is one that is present, is in good physical condition, and remains insecticidal, thereby providing protection against vector-borne diseases through preventing bites and killing disease vectors. The World Health Organization (WHO) prequalifies LLINs that remain adequately insecticidal 3 years after deployment. Therefore, institutional buyers often assume that prequalified LLINs are functionally identical with a 3-year lifespan. We measured the lifespans of 3 LLIN products, and calculated their cost per year of functional life, to demonstrate the economic and public health importance of procuring the most cost-effective LLIN product based on its lifespan.

Pages

Subscribe to RSS - who