Breaking news: Artemisia afra cures tuberculosis
Pascal Gisenya and Nsengiyumva Bati Daddy
Tuberculosis kills 2 000 000 people every year. And the situation is dramatic because the disease becomes resistant to conventional pharmaceutical treatments.
Weblogs
Podcast: Surface Tension Key to Dantu Blood Group Protection
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Malaria Minute, 25 September 2020
The secrets to the Dantu blood group’s innate protection from malaria are revealed, researchers identify the protein needed for efficiency egress of rodent malaria from the liver, and a letter Trends in Parasitology defends the mosquito.
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Open Access Book - Vector Biology and Control: An Update for Malaria Elimination Initiative in India
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Edited by Vas Dev, M.Sc. (Hons.), Ph.D (Notre Dame), FNASc
The National Academy of Sciences, India 2020
This book was commissioned by the National Academy of Sciences, India to spread the current knowledge of the mosquito vectors of human malaria and control options in different geo-epidemiological risk-zones of India. Given the clarion call for malaria elimination by 2027, understanding vector bionomics in the changing ecological context is of paramount importance to formulate species-specific intervention strategies to disrupt transmission of malaria. India is fast accelerating towards the ambitious goal of malaria elimination presenting a window of opportunity for scaling up interventions and developing stronger health systems for universal coverage. This book is of immediate relevance to programme/policy managers and researchers alike, reinforcing continued research on innovative technologies for sustainable control helping end transmission for good in the foreseeable future towards envious goal of a malaria-free world.
For the free pdf of this book please see attachement or download this book here.
Podcast: Multidose Priming and Delayed Boosting Improves PfSPZ Vaccine Efficacy
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Malaria Minute, 18 September 2020
Multi-dose priming and delayed boosting improves PfSPZ protection against different strains of malaria, and registration opens for this year’s Molecular Parasitology Meeting.
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New from MESA: Volunteer as MESA Correspondent to report from the virtual ASTMH Annual Meeting
The Malaria Eradication Scientific Alliance (MESA) is seeking volunteers as MESA Correspondents to report from the virtual ASTMH Annual Meeting happening on November 15 - 19, 2020.
Podcast: Gametocyte-Induced Odour Could Aid Vector Control
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Malaria Minute, 11 September 2020
Harnessing HMBPP metabolites could support vector control, and researchers examine the role of CDPKs in the egress of sporozoites from the liver.
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Malaria and COVID-19: country perspectives
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How have country-based malaria experts adapted to the double challenge of malaria and COVID-19? What successes have they achieved, and where are the remaining gaps? In a virtual forum on 3 September, 10 Ministry of Health representatives shared their experiences and reflections; you can watch their presentations below.
On 4 September, participants heard from senior political and health leaders from 2 regions that are heavily impacted by malaria; you will find below the presentations of WHO’s Regional Director for Africa, India’s Health Secretary and the Ugandan Minister of Health.
Podcast: Researchers Produce Cell Atlas of Mosquito Immune System
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Malaria Minute, 4 September 2020
Researchers produce a ‘cell atlas’ of the mosquito immune system, and new hydrological prediction models identify a more complex pattern of malaria suitability.
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Podcast: Host-Directed Interventions Could Reduce Malaria Burden
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Malaria Minute, 28 August 2020
Inhibiting human protein kinases, which are activated by the malaria parasite, could reduce the malaria burden, and researchers explore the use of AI in automating malaria diagnosis.
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Immunoglobulins and lactoferrrin against viral attacks
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Pascal Gisenya, Pierre Lutgen
Mucosal surfaces represent a major interface between host and environment. They constitute the point of entry of most infectious pathogens, and are in contact with potentially injurious antigens present in the normal mucosal microflora and in ingested or inhaled substances.
MUCOSAL LININGS ARE RICH IN IMMUNOGLOBULINS
Podcast: Artemisinin Resistance Identified in Africa
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Malaria Minute, 21 August 2020
Researchers identify a mutation to the malaria parasite which can drive resistance to artemisinin and people around the world mark World Mosquito Week.
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Podcast: Inspiring mosquito conversation between Care Plus Chief Mosquito Officer Arnoud Aalbersberg and MalariaWorld mosquito biologist Bart Knols
Podcast Episode Care Plus #4: World Mosquito Day
Care Plus Podcast by Travel Health Group, 20 August 2020
Older adults, Zinc deficiency, Artemisia and Corona
submitted by Pierre Lutgen, Jerome Munyangi and Mutaz Akkawi
Zinc (Zn) plays an essential role in many biological processes including immune response. Impaired Zn status promotes immune dysfunction, and it has been associated with enhanced chronic inflammation during aging. Zinc has a pivotal role in the entire immune system fostering resistance to infections by virus, fungi and bacteria. The immune system is strongly impaired by zinc deficiency, predominantly the cell-mediated response by T-lymphocytes.
Podcast: Peptide-Based PD1 Antagonist Stimulates T Cell Responses
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Malaria Minute, 14 August 2020
A peptide derived from Bacillus bacteria stimulates the production of T cells prophylactically and therapeutically, and researchers explore the use of satellite imagery to assess the suitability of malaria vectors in different geographies.
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New from MESA: Malaria Consortium updates its research and implementation activities in MESA Track
Malaria Consortium’s work includes technical assistance, implementation and research activities. One of the main goals of the organisation is to identify innovative approaches for monitoring, evaluation and surveillance systems, and high-quality implementation research leading to evidence-based strategies for the control and eventual elimination of malaria. Browse MESA Track to discover their research efforts in more than 10 countries.
Podcast: New Plasmodium Transporter Channel Identified
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Malaria Minute, 7 August 2020
Scientists identify a new transporter channel in the parasitophorous vacuole, and researchers learn that LLINs in Papua New Guinea have not met the required bioefficacy standards since 2013.
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Podcast: New Insights Into Erythrocyte-Binding Plasmodium Protein
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Malaria Minute, 31 August 2020
Scientists publish new insights into Plasmodium falciparum P2, and the IDDO launch an online tool to map the prevalence of substandard and falsified antimalarial drugs around the world.
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New from MESA: Plasmodium vivax research: A conversation with ICREA Prof Hernando A. del Portillo
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ICREA Prof Hernando A. del Portillo studied molecular aspects of parasites at the University of Georgia, USA, where he received his PhD, followed by two WHO postdoctoral trainings at the New York University Medical Centre (USA) and the Institut Pasteur (France) where he specialized in molecular biology of malaria parasites. Since then, he has pursued molecular studies in Plasmodium vivax malaria to unveil the mechanisms of virulence and to develop rational control strategies in different institutions.
New from MESA: Find out more about MESA Track and how to get involved
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Find out more about the MESA Track online platform and join the database of researchers, funders and institutions working to combat malaria!
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New from MESA: The U.S. President's Malaria Initiative (PMI) celebrates 15 years of partnership and shares over 100 operational research projects in MESA Track
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Since 2006, PMI has partnered with countries hardest hit by malaria, supporting introduction and scaling of proven, life-saving malaria interventions protecting more than 570 million people at risk annually. In countries where PMI works, their investments have significantly contributed to a 27% decline in malaria cases and a 60% decline in malaria deaths.
Podcast: Liver Stage of Plasmodium vivax Characterised
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Malaria Minute, 24 July 2020
Researchers characterise the liver stage of Plasmodium vivax, and scientists discover that two chemicals can inhibit growth of Plasmodium infection.
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Omega-rich oils are efficient against malaria, but may enhance viral infections
In a recent review paper we described the strong antimalarial properties of polyunsaturated fatty acids (PUFA), but also raised some concerns about the potential risks for viral infections.
Jérôme Munyangi, Pierre Lutgen, Artemisia plants, arachidonic and other polyunsaturated fatty acids. Malaria World Journal MWJ 2020, 11:3.
Podcast: Plasmodium Mimics NK-Inhibitor to Evade Immune Response
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Malaria Minute, 17 July 2020
Researchers find that the malaria parasite mimics a natural molecule that inhibits the release of NK cells, and the effect of insecticide resistance on the reproductive potential of Anopheles coluzzii mosquitoes has been revealed.
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Podcast: Mass Drug Administration for Malaria Elimination in Zambia
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Malaria Minute, 10 July 2020
Zambian study reveals that mass drug administration is safe, logistically feasible, accepted by communities, and effective in reducing malaria prevalence in the short term, and the Medicines for Malaria Venture launch Malaria Libre, an open-source drug discovery programme.
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Podcast: Extent of Insecticide Resistance in Africa Revealed
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Malaria Minute, 03 July 2020
The prevalence of insecticide resistance increases in Africa and researchers find that the malaria parasite interferes with red blood cell development to ensure gametocyte maturation.
Podcast: CDK5 Controls Atypical Replication of Plasmodium Parasite
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Malaria Minute, 26 June 2020
CDK5 regulates atypical cell division in gametogony and is essential for DNA replication, and researchers assess whether two experimental vaccines can be combined to create a multistage vaccine against malaria.
New from MESA: Towards a vaccine for Plasmodium vivax (ongoing)
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Malaria-free world has been an ultimate goal embraced by WHO just decade after its foundation, however only 38 countries in temperate zone were able to eliminate malaria since then. In 2017, WHO Executive Board reasserted their full and firm support towards malaria eradication. The lancet commission on Malaria eradication has called for global experts and policy makers to agree upon an ambitious target of eradicating malaria by 2050.
New from MESA: Clinical Epidemiology of COVID-19 in Malaria Settings (ongoing)
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As the novel coronavirus (COVID-19) pandemic continues to evolve it is essential to mitigate risk of increased incidence of other infectious diseases. In malaria-endemic regions, it will be important to understand the potential impact to epidemiological changes, trends in transmission, and clinical presentation of COVID-19 and malaria individually, and as co-infections.
Podcast: Mosquito Saliva Vaccine Evaluated in Phase 1 Clinical Trial
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Malaria Minute, 19 June 2020
Researchers evaluate the immunogenicity of the AGS-v vaccine which targets saliva produced by Anopheles gambiae mosquitoes.
Relapsing Malaria and Parasite Numbers
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Only a "few" hypnozoites occur in patients who have Plasmodium vivax infections, compared to the large, non-circulating merozoite biomass that is now known to be present.
Therefore, to readily ascribe P. vivax malarial recurrences to hypnozoite activation, as is currently common practice, is no longer appropriate without good reasons for doing so. Forget about what you were taught at university in this context and keep an open mind.
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