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Podcast: Researchers Target Plasmepsin as Avenue for Potential New Therapies

March 7, 2020 - 17:33 -- Malaria Minute

Malaria Minute, 7 March 2020

Researchers target Plasmepsin proteases as resistance to ACT grows, and the process by which the malaria parasite suppresses the immune system is detailed by scientists.

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Podcast: Scientists Convene for MAM2020 in Australia

February 29, 2020 - 14:26 -- Malaria Minute

Malaria Minute, 28 February 2020

The Molecular Approaches to Malaria Conference takes place in Australia, and a study into the long-term side effects of antimalarials could not identify any sufficient evidence of association between malaria prophylaxis and adverse health effects.

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Artemisia afra completely inhibits transmission of gametocytes

February 27, 2020 - 19:35 -- Pierre Lutgen

Gametocytes are loaded with hemozoin resulting from hemoglobulin consumption. Their voracious need of this food may explain why they hide in the bone marrow where they find a large supply of young red blood cells generated by erythropoiesis. Malaria leads to hemolysis and anemia, often severe, and this triggers and amplifies erythropoiesis.  Over the years it became evident that not only intravenous artesunate often causes hemolysis, but also ACT therapy.

New from MESA: ASTMH 2019 Recap in the MESA Resouce Hub: Emerging evidence in school-based malaria interventions from Uganda, Rwanda and Mali

February 27, 2020 - 17:45 -- MESA Alliance

Watch the presentations from ASTMH 2019's symposium entitled "Interventions to decrease the burden of malaria in school-aged children", chaired by Dr Julie Gutman and Dr Miriam Laufer. 

Podcast: Condensin Proteins Essential for Malaria Proliferation and Transmission

February 21, 2020 - 17:57 -- Malaria Minute

Malaria Minute, 21 February 2020

Scientists identify two proteins that are essential for the malaria parasite’s genetic malleability, and the substance responsible for ‘rosette’ formation in human red blood cells is identified.

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New from MESA: Volunteer as a MESA Correspondent to report from the "Genomic Epidemiology of Malaria" Conference

February 18, 2020 - 20:06 -- MESA Alliance

The Malaria Eradication Scientific Alliance (MESA) is seeking three volunteers as MESA Correspondents to report from the "Genomic Epidemiology of Malaria" Conference in the Wellcome Genome Campus, UK, June 08 - 10, 2020.

Podcast: EphA2 Protein Mediates Critical Stage of Cerebral Malaria

February 14, 2020 - 17:54 -- Malaria Minute

Malaria Minute, 14 February 2020

Scientists find that the EphA2 protein mediates a critical stage of cerebral malaria and data scientists construct a statistical modelling framework of malaria seasonality in Madagascar.

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Why are antimalarials bitter?

February 7, 2020 - 16:35 -- Pierre Lutgen

From prehistoric times man has looked to wild and domestic animals for sources of herbal remedies. Both folklore and living examples provide accounts of how medicinal plants were obtained by observing the behaviour of animals. Animals too learn about the details of self-medication by watching each other. To date, perhaps the most striking scientific studies of animal self-medication have been made on the African great apes.

RTS,S vaccine: an African medical doctor raises the alarm.

February 1, 2020 - 14:57 -- Pierre Lutgen
Tags: 

 

This document was submitted to us by Jerôme Munyangi, who run the successful large scale clinical trials against malaria with Artemisia plants in Maniema, RDC.

        (Jerome Munyangi et al., Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine(ASAQ) in treating Plasmodium falciparum malaria in a large scale, doubleblind, randomized clinical trialPhytomedicine, 2019, 57, 49-56)

Our association IFBV-BELHERB shares his concern for his African sisters and brothers. They should not be used as guinea pigs by Bigpharma.

 

Podcast: Optimising Vaccine Efficacy Using Tobacco Mosaic Virus

January 31, 2020 - 14:27 -- Malaria Minute

Malaria Minute, 31 January 2020

Use of the tobacco mosaic virus platform to administer malaria antigens induces high and durable efficacy in macaques and individuals with an African-centric genetic variation may have an improved response to malaria.

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Podcast: Optimising Vaccine Efficacy Using Tobacco Mosaic Virus

January 31, 2020 - 14:27 -- Malaria Minute

Malaria Minute, 31 January 2020

Use of the tobacco mosaic virus platform to administer malaria antigens induces high and durable efficacy in macaques and individuals with an African-centric genetic variation may have an improved response to malaria.

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Podcast: Antibodies Marker of Exposure to Malaria in Pregnant Women

January 24, 2020 - 14:18 -- Malaria Minute

Malaria Minute, 24 January 2020

Malaria antibodies in pregnant women may be a marker of exposure, not protection, from malaria and a combination of antimalarial drugs is less efficacious than if used in tandem.

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Podcast: Single-Cell Genome Processing Demonstrates Origin of Complex Malaria

January 17, 2020 - 10:13 -- Malaria Minute

Malaria Minute, 17 January 2020

Single-cell genome processing yields surprising results about the origin of complex malaria and study finds that the management of malaria in children at schools is ineffective.

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Podcast: DNA Methylation Inhibitor Molecules Kill Plasmodium Parasites

January 3, 2020 - 18:12 -- Malaria Minute

Malaria Minute, 3 January 2020

Researchers from the Pasteur Institute discover molecules that can kill the malaria parasite and researchers from LSTM identify a resistance mechanism for insecticides used on bed nets.

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Artemisia afra and blood pressure

December 17, 2019 - 20:03 -- Pierre Lutgen

 

Another important property of Artemisia plants. Might help us to better understand the high efficacy against tropical diseases.  Just published  in PPIJ! See pdf attached

 

And as Artemisia afra is endemic in so many African countries and used since generations as traditional medicine against malaria no further pre-clinical trials are required as per WHO/EDM/TRM/2000.1    

This traditional use is recognized by  WHO in the October 2019 statement WHO-CDS-GMP-2019.14

Podcast: World Malaria Report Places Emphasis on Pregnant Women and Children

December 10, 2019 - 09:42 -- Malaria Minute

Malaria Minute, 6 December 2019

The WHO publish their annual World Malaria Report which, this year, places emphasis on protecting pregnant women and children from malaria.

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The World Malaria Report 2019 is out!

December 4, 2019 - 14:34 -- Malaria World

More pregnant women and children protected from malaria, but accelerated efforts and funding needed to reinvigorate global response, WHO report shows

The World malaria report 2019 provides a comprehensive update on global and regional malaria data and trends. The report tracks investments in malaria programmes and research as well as progress across all intervention areas: prevention, diagnosis, treatment, elimination and surveillance. It also includes dedicated chapters on the consequences of malaria on maternal, infant and child health, the “High Burden to High Impact” approach as well as biological threats to the fight against malaria.

The 2019 report is based on information received from more than 80 countries and areas with ongoing malaria transmission. This information is supplemented by data from national household surveys and databases held by other organizations.

Download the World Malaria Report 2019

First malaria vaccine rolled out in Africa - despite limited efficacy and nagging safety concerns

November 28, 2019 - 13:29 -- Malaria World

Science, Nov. 26, 2019: by Jop de Vrieze

MALAWI—In a small room at the Phalula Health Centre in southern Malawi's Balaka district, two young mothers are sitting on a wooden bench, each with a 5-month-old baby on their lap. Across from them, behind a desk, sits Alfred Kaponya, a community health worker. A colleague is busy preparing a vaccine, tapping the syringe to dislodge bubbles. Kaponya explains the procedure to the women, writes down the vaccines' serial numbers in the children's vaccination booklets, and copies them onto a spreadsheet in his binder.

Why Artemisia stems are more important than leaves for antimalarial infusions

November 28, 2019 - 08:35 -- Pierre Lutgen

For figures see attached pdf

There are many anecdotic reports indicating that including stems and twigs with dried Artemisia leaves augments the power of the infusion. Operators of a palm oil plant in Burundi only drink infusions made with stems and stay malaria free.

Dried Artemisia annua herb of Chinese origin and sold in European pharmacies contains at least 70 % of stems.

Podcast: Traditional Soup Recipes Have Antimalarial Properties

November 22, 2019 - 11:22 -- Malaria Minute

Malaria Minute, 22 November 2019

Schoolchildren find that some of their families’ soup recipes have antimalarial properties and a Swiss-led team of cell biologists identify hundreds of targets needed in drug and vaccine development.

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