A team of medical doctors and traditional healers in the Eastern part of the DR Congo just completed the first part of clinical trials studying the efficacy of Artemisia annua against gametocytes. The trials were following a protocol based on the procedures recommended by WHO and are coordinated with a team of medical doctors from France.
Pierre Lutgen's blog
Polyphenols are a large group of antioxidants naturally known for their protective effect against oxygen metabolites, acting as free radical scavengers. In contrast to the beneficial effects it has recently been reported that some polyphenols may promote oxidative damage. These harmful effects are suspected to result from a pro-oxidant action.
Although resistance is increasing at an exponential rate, synthetic pyrethroids remain the only recommended insecticides for mosquito nets. One may wonder what the reasons behind this monopoly are : incompetence or business ?
After some important research work had been done some 30 years ago on amino acids, the impact these molecules might have on a vast array of diseases has been neglected. But there is increasing evidence that the amino acid proline plays an important role in the virulence mechanism of human and mammalian pathogens.
As most of the people suffering from malaria are living in French speaking countries we post also a French version
Les plantes de la grande famille des armoises sont utilisées comme herbes médicinales depuis des millénaires dans toutes les régions du monde.
L’Artemisia annua est venue sous les feux de la rampe lors de la guerre du Vietnam.
The large family of Artemisia plants have been used as herbal medicine for millenniums in all regions of the world.
Amino-acids in Artemisia annua have barely been studied. The analytical data published by EA Brisibe and J Ferreira date back to 2009 (Food Chemistry, 2009, 115, 1240-1246). Their role in malaria infections has been ignored, except for a study published in Japan (DT Uyen et al., Biol Pharm Bull. 2008, 31, 1483-1488). To gain insight into the mechanism of malarial haemozoin formation, they examined the effects of amino acids on beta hematin formation in vitro. Surprisingly some of these amino acids like arginine, histidine, lysine showed a significant inhibition.
Luteolin (3′,4′,5′,7′-tetrahydroxyflavone) is a widespread flavonoid aglycon structurally related to quercetin. The ethnobotanical use of this flavone includes applications in the treatment of cough, diarrhea, dysentery, diabetes, cancer and malaria.
Moringa oleifera is called the „miracle tree“, and has a strong reputation for curing many diseases, but it is impossible to find any peer reviewed paper on PubMed which describes antimarial properties for this plant. This probably does not exclude the presence in the plant of a few molecules which could demonstrate antiplasmodial properties in vitro.
Dry leaves of the plant do not inhibit beta-hematin (G Mergeai, personal communication) in the assay which is often used to screen for antimalarials.
On October 23 , 2014 WHO issued a recommandation (www.who.int/elena/titles/zinc_diarrhoea) stating that mothers, other caregivers and health workers should provide children with 20 mg per day of zinc supplementation for 10-14 days (10 mg per day for infants under the age of six months).