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Pierre Lutgen's blog

The ambiguous role of glutathione in malaria

October 3, 2015 - 19:41 -- Pierre Lutgen

Parasites are endowed with powerful and host-independant mechanisms which de novo synthesize or regenerate reduced glutathione (GSH) and protect the parasites from oxidative damage. GSH can penetrate from the extracellular space into the host cytosol but the parasite membrane is impermeable to peptides (H Atamna et al., Eur J Biochem 1997, 15, 670-9).. Glutathione is one of the most powerful anti-oxidants. It is a tripeptide formed by the amino acids glycine, cysteine and glutamic acid. It inhibits the action of arginine which produces NO and expels it from the food vacuole.

Santonin from Artemisia campestris: a famous forgotten anthelmintic.

September 18, 2015 - 06:04 -- Pierre Lutgen

200 years ago, in 1830 the anthelmintic properties of santonin were discovered , simultaneously by Dr Kahler in Düsseldorf and Dr Alms in Mecklenburg in a plant from Turkestan, Artemisia cina. Its presence, although at lower concentrations, was later found in Artemisia maritima, Artemisia campesris, Artemisia gallica, Artemisia absinthium, Artemisia sieberi. (Berichte der Deutschen Chemischen Gesellschaft , 1867, Vol 6, 875-1670). Stanislao Cannizzaro is known widely for his , "Sunto di un corso di filosofia chimica", on santonin which he presented at the Karlsruhe Congress of 1860.

Cod liver oil: a stronger prophylactic against malaria than vaccines!

September 8, 2015 - 14:24 -- Pierre Lutgen

In 1957 the University of London found that dietary cod liver oil suppressed the multiplication of Plasmodium berghei in mice (DG Godfrey, Experimental Parasitology, 1957, 6, 555-565), of Babesia rodhaini (DG Godfrey, Experimental Parasitology 1957, 6-5, 465-485) and of Trypanosoma congolense (D G Godfrey , Experimental Parasitology, 1958, 3, 255-268).

Artemisia annua efficiently cures bilharzia

August 26, 2015 - 19:36 -- Pierre Lutgen

Bilharzia, schistosomiasis, snail fever, is a disease caused by parasitic worms of the Schistosoma type. It may infect the urinary tract or the intestines. Signs and symptoms may include abdominal pain, diarrhea, bloody stool, or blood in the urine. In those who have been infected for a long time, liver damage, kidney failure, infertility, or bladder cancer may occur. Schistosomiasis affects almost 210 million people worldwide, and an estimated 200,000 people die from it a year, 

Artemisia annua from Luxembourg efficiently kills gametocytes!

August 20, 2015 - 18:56 -- Pierre Lutgen

A team of medical doctors and traditional healers in the Eastern part of the DR Congo just completed the first part of clinical trials studying the efficacy of Artemisia annua against gametocytes. The trials were following a protocol based on the procedures recommended by WHO and are coordinated with a team of medical doctors from France.

Bicarbonates, hydrogen peroxide and malaria.

August 13, 2015 - 15:28 -- Pierre Lutgen

Polyphenols are a large group of antioxidants naturally known for their protective effect against oxygen metabolites, acting as free radical scavengers. In contrast to the beneficial effects it has recently been reported that some polyphenols may promote oxidative damage. These harmful effects are suspected to result from a pro-oxidant action.

Proline: fuel for parasites, worms, bacteria, fungi.

July 31, 2015 - 18:06 -- Pierre Lutgen

After some important research work had been done some 30 years ago on amino acids, the impact these molecules might have on a vast array of diseases has been neglected. But there is increasing evidence that the amino acid proline plays an important role in the virulence mechanism of human and mammalian pathogens.

Artemisia: efficient but banished (FRENCH VERSION)

July 22, 2015 - 16:43 -- Pierre Lutgen

As most of the people suffering from malaria are living in French speaking countries we post also a French version

 

Les plantes de la grande famille des armoises sont utilisées comme herbes médicinales depuis des millénaires dans toutes les régions du monde.

L’Artemisia annua est venue sous les feux de la rampe lors de la guerre du Vietnam.

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