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Pierre Lutgen's blog

Artesunate causes recrudescence, Artemisia however kills gametocytes

February 16, 2016 - 11:03 -- Pierre Lutgen

A paper from Mali published last week is alarming (AA Djimbe et al., Parasite, 2016. 23, 3). Artesunate does not clear mature gametocytes during oral artesunate treatment and does not prevent the appearance of new gametocytes. This confirms to a large extent the randomized, double blind, large scale clinical trials of Munyanga and Idumbo in Maniema-Congo end of last year (see www.malariaworld.org).

Artemisia defeats schistosomiasis

February 9, 2016 - 12:53 -- Pierre Lutgen

In parallel with the clinical trials run by a team of medical doctors in the province of Maniema on the efficiency of Artemisia annua and Artemisia afra against malaria, (see Breaking News Jan.5 on www.malariaworld.org) they have completed another large scale randomized, double blind trial against schistosomiasis, Artemisia vs Praziquantel.

The strong prophylactic and antimalarial properties of polyunsaturated fatty acids.

February 3, 2016 - 13:08 -- Pierre Lutgen

ABSTRACT

Artemisia plants are rich in polyunsaturated fatty acids (PUFA) which generate prostaglandins and stimulate monocytes. PUFAs possess well documented antimalarial and prophylactic properties. Their half-life in plasma is several days and in adipose tissue several weeks. This may explain the prophylactic effect of regular consumption of Artemisia infusion or powder.

INTRODUCTION

Breaking news from clinical trials with Artemisia plants

January 5, 2016 - 15:30 -- Pierre Lutgen

A team of medical doctors in RDCongo, Jerome Munyangi and Michel Idumbo, have run randomized clinical trials on a large scale in the Maniema province with the participation of some 1000 malaria infected patients. The trials were run in conformity with the WHO procedures and compared Artemisia annua and Artemisia afra with ACTs (Coartem and ASAQ). For all the parameters tested herbal treatment was significantly better than ACTs: faster clearance for fever and parasitemia, absence of parasites on day 28 for 99.5% of the Artemisia treatments and 79.5% only for the ACT treatments.

Malaria, diabetes and arginine

December 12, 2015 - 09:26 -- Pierre Lutgen

Diabetes burden is rising sharply in the African Region according to Dr Matshidiso Moeti, the WHO Regional Director for Africa. Reports of type 2 diabetes in children – previously rare – is a growing concern. In some countries, children and adolescents account for almost half of all newly diagnosed cases of type 2 diabetes. Diabetes is a leading cause of blindness, amputation, kidney failure and heart disease.

Palustop: antimalarial suppository from Cameroon for children

December 7, 2015 - 21:17 -- Pierre Lutgen

Rosine D. Chougouo NKuitchou1, Ernest Djoko1, Jonas Kouamouo1, Diane F. Domko1, Pierre Tane2, Denis Wouessidjewe1,3. 

1 Faculty of Pharmacy, Université des Montagnes »P O Box 208 Bangangte, Cameroon 2 Laboratory of Natural Products Chemistry, Faculty of Sciences, University of Dschang P O Box 67 Dschang Cameroon 3 UFR of Pharmacy, Department of Molecular Pharmacochemistry, University of Joseph Fourrier of Grenoble PO Box 53 38041 Grenoble Cedex 9.

 

Does artesunate promote malaria transmission?

December 3, 2015 - 15:34 -- Pierre Lutgen

The amino acid arginine is the only molecule in our food known to generate nitric oxide NO via NOS enzymes. It plays a key role in malaria therapy and cerebral malaria as described in previous blogs on www.malariaworld.org. NO derived from arginine is not only lethal for merozoites but also for gametocytes. NO is efficient against other diseases like leishmaniasis or filariasis (R O’Connor et al., Infection and Immunity, 2000, 68, 6101-6107).

Zinc and beta-hematin inhibition

November 25, 2015 - 07:52 -- Pierre Lutgen

Our partners at the Al Quds University in Palestine have found that a zinc-arginine complex strongly inhibits beta-hematin crystallization, like quinine does, but that zinc or arginine alone are not effective. Arginine and zinc play an important role in the human physiology. The plants from the Artemisia family are rich in these constituents which play probably a key role against malaria and other diseases. They easily form a complex in a large range of reagent concentrations (E Bottari et al., Monatshefte Chemie 2014, 145, 1707-1714).

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