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Pierre Lutgen's blog

Diabetes, obesity and malaria: synergy or antagonism

December 24, 2016 - 17:28 -- Pierre Lutgen

Sugar feeding is a fundamental characteristic of mosquito life. It is the basic food of adult mosquitoes, as floral nectar or honeydew. It is the only nutrient consumed by males and probably the more common one for females, even if they need vertebrate blood to produce eggs. Malaria parasites also are dependent on glucose as a nutrient source. As Plasmodium has no capacity to store energy in the form of glycogen they rely entirely on an exogenous supply of glucose. The infected erythrocyte exhibits a substantial increase in its permeability to low molecular weight sugar.

PCR genotyping: reliable or misleading?

November 28, 2016 - 17:04 -- Pierre Lutgen

A press release from Wellcome Trust Sanger Institute raised a lot of concern. Based on a scientific paper published in Nature

           Magnus Manske, Olivo Miotto, Susana Campino, Sarah Auburn, Jacob Almagro-Garcia, Gareth Maslen, Jack O’Brien, Abdoulaye Djimde, Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487, 375–379, 19 July 2012doi:10.1038/nature11174

Studies from 2009 already asked the same question

Artesunate enhances malaria transmission, Artemisia afra blocks it

November 22, 2016 - 15:23 -- Pierre Lutgen

 

It is generally or it was believed that quinine is prophylactic. But several papers have questionned this believe and a large scale clinical trial from India in 1918 demonstrated that it is not the case and that large quantities of quinine have been swallowed by a large number of people without providing protection against the infection nor significantly reducing transmission

      G Waugh Scott. Quinine prophylaxis in malaria. Brit Med Journal, 1918, May 11th.

Obliterated, erased. Bhy who? by WHO?

November 5, 2016 - 07:19 -- Pierre Lutgen

Several scientific papers have disappeared from internet.

For example the clinical trials with Artemisia annua in RD Congo from 2000 (attachment 1)

(M.S. Mueller , I.B. Karhagomba , H.M. Hirt , E. Wemakor. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. Journal of Ethnopharmacology 73 (2000) 487–493)

and clinical trials  2002 (attachment 2)

Tannins in Artemisia: hidden treasure for prophylaxis

October 9, 2016 - 15:53 -- Pierre Lutgen

 

Proanthocyanidins (condensed tannins) are oligomeric and polymeric products of the flavonoid biosynthetic pathway. They are present in the fruits, bark, leaves and seeds of many plants, wine and teas, and are increasingly recognized as having beneficial effects on human health. They have attracted little interest in malaria research because in vitro they show no significant antimalarial activity.

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