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Pierre Lutgen's blog

ARTAVOL malaria prophylaxis on BBC

March 27, 2013 - 16:35 -- Pierre Lutgen

Uganda Science Festival . African approaches against tropical diseases.

Listen to Dr Patrick Ogwang on BBC World Service, London Focus on Africa (radio) on Mar 28 3.30-5-30PM

Dear Moussa. Thank you very much for the opportunity to discuss science in Africa. I strongly believe that Africa must set her science agenda if we are to benefit from science. Why? For the following reasons;

Is PCR genotyping of Plasmodium falciparum a reliable tool for monitoring drug resistance?

February 9, 2013 - 19:15 -- Pierre Lutgen

A recent press release from Wellcome Trust Sanger Institute raised a lot of concern. Based on a scientific paper published in Nature, 13 June 2012, it appears that a single infected person could harbour many genetically different Plasmodium falciparum parasites. The team from Oxford University found that these parasite populations easily swap DNA to create new forms.

This evidently raises the question how far PCR (polymer chain reaction genotyping) can distinguish between recrudescence (or treatment failure) and re-infection by new bites from anopheles mosquitoes.

Artemisia annua prevents transmission of malaria from man to mosquito

December 30, 2012 - 17:12 -- Pierre Lutgen

In the human body the parasite injected into the bloodstream by the mosquito undergoes the transformation from the asexual plasmodium into the sexual gametocytes which the mosquito is going to pick-up during its blood meal. The killing effect of artemisinin on gametocytes is known since twenty years and was first mentioned in in vitro trials at the John Hopkins University. These results were confirmed in 1993 by research teams in China and India and mentioned in the document WHO/MAL/98.1086.

Open questions concerning artemisinin and its derivatives

October 22, 2012 - 14:27 -- Pierre Lutgen

The article below was written by Dr. Pierre Lutgen (see www.maladiestropicales.org and www.iwerliewen.org; email: lutgenp@gms.lu).

Abstract

We selected three papers among many others raising concerns about the failure of  ACTs.
 
In the Chinese paper from Liu AR et al (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(2):76-8) it was documented that essential oil from a plant (also called patchouli oil) had extraordinary y synergistic properties with artesunate.  This essential oil even reverses the resistance against Plasmodium berghei in mice. Why were ACTs based on chemical and not on natural molecules?
 
The inhibition of Plasmodium with extracts from the Artemisia ludoviciana plant from Mexico is up to 98,6%. The plant does not contain artemisinin (F Malagon et al.  Parasitologia. 1997 ;39(1):3-7).
 
The paper from Vietnam (V Ha et al. Trans R Soc Trop Med Hyg. 1997 Jul-Aug;91(4):465-7)   claims that there is no significant difference between artemisinin, artemether, artesunate treatment! Why than produce ACT pills with artemisinin derivatives?

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