Mutaz Akkawi, Pascal Gisenya, Jérôme Munyangi, Pierre Lutgen
…or the key of malaria transmission.
Already 25 years ago it was known that malaria pigment (hemozoin, Hz, biocrystallized heme) is not an inert material. Crude pigment, as present in infected erythrocytes and shed after schizont rupture, may be considered the 'natural diet' ingested by macrophages in infected blood. Hemozoin is a powerful source of radicals, necrosis factor-alpha, interleukins 1 and 6.