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Pierre Lutgen's blog

Hemozoin and Malaria : a love-hate affair

July 5, 2021 - 17:31 -- Pierre Lutgen

Mutaz Akkawi, Pascal Gisenya, Jérôme Munyangi, Pierre Lutgen

…or the key of malaria transmission.

Already 25 years ago it was known that malaria pigment (hemozoin, Hz, biocrystallized heme) is not an inert material. Crude pigment, as present in infected erythrocytes and shed after schizont rupture, may be considered the 'natural diet' ingested by macrophages in infected blood. Hemozoin is a powerful source of radicals, necrosis factor-alpha, interleukins 1 and 6.

Arginine, Malaria, Helminths and Covid,

March 15, 2021 - 20:06 -- Pierre Lutgen

In my recent weblog « Africa, Covid and Schistosomiasis » I documented that eosinophilia is common in helminthic infections (www.malariaworld.org 14/01/2021) and that this might significatly contribute to a protection against viral infections. And that this could explain the low incidence of Covid in tropical African countries.

Zinc, Covid and hypertension

March 4, 2021 - 19:14 -- Pierre Lutgen

A few years ago we described in a blog on www.malariaword.org the role zinc may have in diarrhea and tropical diseases. Zn2+ deficiency is a common comorbidity of many chronic diseases.

In a recent weblog we describe the deleterious effect of zinc deficiency in elderly people on the development of pneumonia. Zinc deficiency has a detrimental effect on blood pressure and hypertension is one of the major causes of mortality in Covid infections.

Covid-19, Malaria, Diabetes, Obesity and Eosinophils

February 8, 2021 - 15:44 -- Pierre Lutgen

An increased number of scientific papers confirm that diabetes causes an increased risk in the mortality and severity of COVID-19. However, the mechanism is not entirely clear. Understanding the relationship between COVID-19 and diabetes could advance therapeutic measures, but there is a scarcity of data on the matter.

Gina Dube, an advanced practice clinical pharmacist at Brigham and Women’s Hospital in Boston, Massachusetts suggests that impaired immune systems make individuals with diabetes more susceptible to severe infections.

Covid, Africa and Schistosomiasis

January 5, 2021 - 19:55 -- Pierre Lutgen

In an April 10 interview, American philanthropist Melinda Gates expressed her belief that the coronavirus pandemic will have the worst impact in the developing world. She said she foresees bodies lying around in the street of African countries. It is quite surprising to see that although there have been shocking reports of hospitals overwhelmed with patients in the US and in other Western countries, the billionaire philanthropist and others like her still choose to talk about dead bodies in Africa. Gates is not the only one to be predicting total doom in Africa.

Zinc, Covid and the elderly

December 16, 2020 - 14:21 -- Pierre Lutgen

LOW ZINC STATUS: A RISK FOR PNEUMONIA IN THE ELDERLY

Plasma Zn decrease is strongly related to age and may be a predictor of all-cause mortality in elderly population. In a study in Italy plasma zinc levels were measured in individuals having an age range of 10–93 years. No significant differences in plasma zinc concentrations were found between males and females. Up to the age of 50 years, the mean plasma zinc of normal individuals remained relatively constant at 70 ± 32µg/100 ml after which the levels decreased.

Artemisia twigs, nitrate, malaria, schistosomiasis and tuberculosis

December 12, 2020 - 18:06 -- Pierre Lutgen

Many anecdotical or scientific results indicate that leaves and stems of Artemisia annua have different therapeutical properties, often higher for leaves, sometimes lower.
Our efforts so far to elucidate key factors explaining these differences have failed. Artemisinin, polyphenols, essential oils are higher in leaves, scopoletin sometimes lower. If the therapeutical properties against malaria, bacteria or nematodes, really are proportional to the concentration of these organic key constituants, the healing power of stems and twigs should be close to zero.

A catholic organisation in Austria dislikes film on herbal medicine.

October 22, 2020 - 11:58 -- Pierre Lutgen

The film « The Fever » of Katharina Weingärtner was released on September 25 and is well received by public and media. It depicts the fight of African universities and grassroot organizations for local solutions and remedies against the sharp increase in malaria fatalities over the recent years. 500 000 more in 2020 according to WHO !

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