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Pierre Lutgen's blog

Omega-rich oils are efficient against malaria, but may enhance viral infections

July 21, 2020 - 07:43 -- Pierre Lutgen

In a recent review paper we described the strong antimalarial properties of polyunsaturated fatty acids (PUFA), but also raised some concerns about the potential risks for viral infections.

            Jérôme Munyangi, Pierre Lutgen, Artemisia plants, arachidonic and other polyunsaturated fatty acids. Malaria World Journal MWJ 2020, 11:3.

Malaria inhibits Covid

June 10, 2020 - 17:50 -- Pierre Lutgen

 

The role of immunoglobulines E

In January 2020 we published together with 3 medical doctors from Africa: “Jérôme, Munyangi, Pascal Gisenya, Patrick Ogwang …Immunoglobulins in the skin lead to long-lasting prophylaxis. Pharm Pharmacol Int Journal, PPIJ, 2020, Issue1”, a paper which, if widely spread, could have had a dramatic impact on the way the present Covid-19 crisis is handled.

One of the key findings of their work is that immunoglobulins are higher in malaria endemic areas.

Viruses, Malaria, Platelets and Artemisia

May 23, 2020 - 10:12 -- Pierre Lutgen

 

In my previous comments on www.malariaworld.org I alerted to the possibility that the widespread malaria infections in sub-Saharan Africa might provide a protection against the Covid virus. Trying to find an explanation for this observation might be important.

Artemisia afra completely inhibits transmission of gametocytes

February 27, 2020 - 19:35 -- Pierre Lutgen

Gametocytes are loaded with hemozoin resulting from hemoglobulin consumption. Their voracious need of this food may explain why they hide in the bone marrow where they find a large supply of young red blood cells generated by erythropoiesis. Malaria leads to hemolysis and anemia, often severe, and this triggers and amplifies erythropoiesis.  Over the years it became evident that not only intravenous artesunate often causes hemolysis, but also ACT therapy.

Why are antimalarials bitter?

February 7, 2020 - 16:35 -- Pierre Lutgen

From prehistoric times man has looked to wild and domestic animals for sources of herbal remedies. Both folklore and living examples provide accounts of how medicinal plants were obtained by observing the behaviour of animals. Animals too learn about the details of self-medication by watching each other. To date, perhaps the most striking scientific studies of animal self-medication have been made on the African great apes.

RTS,S vaccine: an African medical doctor raises the alarm.

February 1, 2020 - 14:57 -- Pierre Lutgen
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This document was submitted to us by Jerôme Munyangi, who run the successful large scale clinical trials against malaria with Artemisia plants in Maniema, RDC.

        (Jerome Munyangi et al., Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine(ASAQ) in treating Plasmodium falciparum malaria in a large scale, doubleblind, randomized clinical trialPhytomedicine, 2019, 57, 49-56)

Our association IFBV-BELHERB shares his concern for his African sisters and brothers. They should not be used as guinea pigs by Bigpharma.

 

Artemisia afra and blood pressure

December 17, 2019 - 20:03 -- Pierre Lutgen

 

Another important property of Artemisia plants. Might help us to better understand the high efficacy against tropical diseases.  Just published  in PPIJ! See pdf attached

 

And as Artemisia afra is endemic in so many African countries and used since generations as traditional medicine against malaria no further pre-clinical trials are required as per WHO/EDM/TRM/2000.1    

This traditional use is recognized by  WHO in the October 2019 statement WHO-CDS-GMP-2019.14

Why Artemisia stems are more important than leaves for antimalarial infusions

November 28, 2019 - 08:35 -- Pierre Lutgen

For figures see attached pdf

There are many anecdotic reports indicating that including stems and twigs with dried Artemisia leaves augments the power of the infusion. Operators of a palm oil plant in Burundi only drink infusions made with stems and stay malaria free.

Dried Artemisia annua herb of Chinese origin and sold in European pharmacies contains at least 70 % of stems.

No toxicity detected for Artemisia annua or afra

August 5, 2019 - 19:06 -- Pierre Lutgen

Artemisias are used since millenaries and never any toxic effect was noticed. If there was one it would have been highlighted by Bigparma because the plant competes with their pills.

The WHO guidelines state that, if the herbal product has been traditionally used without demonstrated harm, no specific restrictive action should be undertaken. In this case WHO maintains the position that there is no requirement for pre-clinical toxicity testing. Pre-clinical toxicity testing is only required for new medicinal herbal products which contain herbs of no traditional history of use.

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