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Pierre Lutgen's blog

Malaria prophylaxis with amiodarone (cordarone).

August 25, 2018 - 17:49 -- Pierre Lutgen

Amiodarone which is used to control irregular heartbeat also has a protective effect in malaria. It triggers eryptosis and the clearance of malaria infected erythrocytes. In Plasmodium berghei infected mice amiodarone injections increased the survival. It is interesting to note that amiodarone is also active against other tropical diseases like Chagas or Leishmaniasis, both in vitro and in vivo, probably by disrupting the parasites' Ca(2+) homeostasis,

Platelets, eryptosis, amiodarone, aspirin, Artemisia

August 12, 2018 - 17:46 -- Pierre Lutgen

THROMBOCYTOPENIA

Thrombocytopenia is a common finding in malaria. Median platelet counts are lower among severe cases than in mild cases, and in children who died than among those who recovered. Infected erythrocytes may adhere to platelets, and the clumps of infected erythrocytes and platelets are associated with severe disease.

    Patrick Gérardin, Christophe Rogier, Amadou S Ka, Philippe Jouvencel, Prognostic value of thrombocytopenia in African children with falciparum malaria. The American Journal of Tropical Medicine and Hygiene 2002 Volume 66, Issue 6.

Transmission blocking vaccines fail, but Artemisia is very efficient

August 4, 2018 - 13:05 -- Pierre Lutgen

Vaccines blocking the invasion of malaria sporozoites failed so far, after 30 years of efforts, millions spent, and disastrous human clinical trials. The efforts and the millions are now focused on vaccines blocking transmission by gametocytes. The results are not yet encouraging but the updated Malaria Vaccine Technology Roadmap foresees that there will be a TBV vaccine available in 2030. The update was necessary as the program launched by WHO in 2000 ( TDR/RBM/MAL/VAC/2000.1) has not yet progressed very far.

Stability of Artemisia plants after ageing

July 11, 2018 - 19:05 -- Pierre Lutgen

In 2001 WHO posted a statement on their home page, without signatures, without references: « Due to the instability of artemisinin in raw materials of Artemisia annua L, the leaves need to be stored in cool conditions — preferably below 20°C. Most malaria endemic countries have warm climates and people generally lack access to refrigeration, so it is difficult for patients to keep artemisinin-containing tea bags under 20°C in their homes” A statement not substantiated by scientific papers. Cui bono?

Our associations immediately gathered available data which prove the contrary

The 2006 pioneering clinical trials Artemisia annua vs ACT in Cameroon

April 17, 2018 - 08:02 -- Pierre Lutgen

                       Etude comparative de l’efficacité in vivo de l’artesunate avec l’amodiaquine et la tisane Artemisia annacultivée à Bangangté à l’Ouest du Cameroun

Chougouo Kengne R.D*., Kouamouo J*., Moyou Somo R**., Penge On’Okoko A***. *Université des Montagnes, Bangangté, Cameroun ; ** IMPM /CRM et FMSB Cameroun; *** Université de Kinshasa RDC. 

Abstract (excerpt):

Ecotoxic impacts of Ivermectin

April 13, 2018 - 14:09 -- Pierre Lutgen

This anthelminthic is extensively used as veterinary medicine to control gastro-intestinal helminthes, liver flukes and lungworms. It enters into the environment primarily through its excretion, 98% in faeces

        Halley BA, Nessel RJ, Lu AYH, Chemosphere. 1989. 18, 1543-1563.

Ivermectin may be stored for long periods in soil.

        Mougin C, Kollmann, A Galtier P. Envir Chem Lett 2003, 1, 131,-134.

The potential of anthelminthics to affect dung decomposition is well known, affecting dung beetles, dung flies and epigeic eathworms.

Prophylaxis against malaria with Azadirachta extracts and NeemAzal*

December 17, 2017 - 09:51 -- Pierre Lutgen

Azardirachta indica, Neem, is considered as the miracle tree against many diseases in many countries. One of the specific molecules of this plant is the limonoid azadirachtin, with a concentration of 0.1g/100 g in the leaves and 0.9 g/100 in the kernels.

Anthocyanins, caffeoylquinic acids, wound and ulcer healing

September 21, 2017 - 08:19 -- Pierre Lutgen

Already in 1925 burns were treated with tannins.

As it often happened in the past century the use of this natural product in the treatment of wounds was abandoned in the mid-forties due to the availability of topical antibacterial agents. It has regained interest. A clinical trial in Malawi comparing a decoction of ground tea stalks with silver sulfadiazine gave better results for bacterial growth, eschar formation.

            L Chokotho, E van Hasselt. The use of tannins in the local treatment of burn wounds-a pilot study. Malawi Med Journal, 2005, 17, 19-20

Anthocyanins and sickle cells

September 5, 2017 - 18:42 -- Pierre Lutgen

Anthocyanins are generally accepted as the largest and most important group of water-soluble pigments in nature. Research articles on anthocyanins have escalated dramatically in the last 20 years : 230 in the decade from 1982 through 1991, 753 from 1992 through 2001 and 3043 from 2002 through 2012 Anthocyanin pigments and associated flavonoids have demonstrated ability to protect against a myriad of human diseases.

        Mary Ann Lila, Anthocyanins and Human Health : an in vitro investigative Approach. J Biomed Biotechnol 2004, 5. 306-313

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