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Pierre Lutgen's blog

Why Artemisia stems are more important than leaves for antimalarial infusions

November 28, 2019 - 08:35 -- Pierre Lutgen

For figures see attached pdf

There are many anecdotic reports indicating that including stems and twigs with dried Artemisia leaves augments the power of the infusion. Operators of a palm oil plant in Burundi only drink infusions made with stems and stay malaria free.

Dried Artemisia annua herb of Chinese origin and sold in European pharmacies contains at least 70 % of stems.

No toxicity detected for Artemisia annua or afra

August 5, 2019 - 19:06 -- Pierre Lutgen

Artemisias are used since millenaries and never any toxic effect was noticed. If there was one it would have been highlighted by Bigparma because the plant competes with their pills.

The WHO guidelines state that, if the herbal product has been traditionally used without demonstrated harm, no specific restrictive action should be undertaken. In this case WHO maintains the position that there is no requirement for pre-clinical toxicity testing. Pre-clinical toxicity testing is only required for new medicinal herbal products which contain herbs of no traditional history of use.

Artemisia et Paludisme: la santé entre les mains des Africains

September 29, 2018 - 13:13 -- Pierre Lutgen

The French periodical PARIS MATCH published an extensive document on the fight against malaria with Artemisia annua and Artemisia afra. And the dubious role WHO plays.

Malaria prophylaxis with amiodarone (cordarone).

August 25, 2018 - 17:49 -- Pierre Lutgen

Amiodarone which is used to control irregular heartbeat also has a protective effect in malaria. It triggers eryptosis and the clearance of malaria infected erythrocytes. In Plasmodium berghei infected mice amiodarone injections increased the survival. It is interesting to note that amiodarone is also active against other tropical diseases like Chagas or Leishmaniasis, both in vitro and in vivo, probably by disrupting the parasites' Ca(2+) homeostasis,

Transmission blocking vaccines fail, but Artemisia is very efficient

August 4, 2018 - 13:05 -- Pierre Lutgen

Vaccines blocking the invasion of malaria sporozoites failed so far, after 30 years of efforts, millions spent, and disastrous human clinical trials. The efforts and the millions are now focused on vaccines blocking transmission by gametocytes. The results are not yet encouraging but the updated Malaria Vaccine Technology Roadmap foresees that there will be a TBV vaccine available in 2030. The update was necessary as the program launched by WHO in 2000 ( TDR/RBM/MAL/VAC/2000.1) has not yet progressed very far.

Stability of Artemisia plants after ageing

July 11, 2018 - 19:05 -- Pierre Lutgen

In 2001 WHO posted a statement on their home page, without signatures, without references: « Due to the instability of artemisinin in raw materials of Artemisia annua L, the leaves need to be stored in cool conditions — preferably below 20°C. Most malaria endemic countries have warm climates and people generally lack access to refrigeration, so it is difficult for patients to keep artemisinin-containing tea bags under 20°C in their homes” A statement not substantiated by scientific papers. Cui bono?

Our associations immediately gathered available data which prove the contrary

The 2006 pioneering clinical trials Artemisia annua vs ACT in Cameroon

April 17, 2018 - 08:02 -- Pierre Lutgen

                       Etude comparative de l’efficacité in vivo de l’artesunate avec l’amodiaquine et la tisane Artemisia annacultivée à Bangangté à l’Ouest du Cameroun

Chougouo Kengne R.D*., Kouamouo J*., Moyou Somo R**., Penge On’Okoko A***. *Université des Montagnes, Bangangté, Cameroun ; ** IMPM /CRM et FMSB Cameroun; *** Université de Kinshasa RDC. 

Abstract (excerpt):

Ecotoxic impacts of Ivermectin

April 13, 2018 - 14:09 -- Pierre Lutgen

This anthelminthic is extensively used as veterinary medicine to control gastro-intestinal helminthes, liver flukes and lungworms. It enters into the environment primarily through its excretion, 98% in faeces

        Halley BA, Nessel RJ, Lu AYH, Chemosphere. 1989. 18, 1543-1563.

Ivermectin may be stored for long periods in soil.

        Mougin C, Kollmann, A Galtier P. Envir Chem Lett 2003, 1, 131,-134.

The potential of anthelminthics to affect dung decomposition is well known, affecting dung beetles, dung flies and epigeic eathworms.

Prophylaxis against malaria with Azadirachta extracts and NeemAzal*

December 17, 2017 - 09:51 -- Pierre Lutgen

Azardirachta indica, Neem, is considered as the miracle tree against many diseases in many countries. One of the specific molecules of this plant is the limonoid azadirachtin, with a concentration of 0.1g/100 g in the leaves and 0.9 g/100 in the kernels.


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