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Pierre Lutgen's blog

The 2006 pioneering clinical trials Artemisia annua vs ACT in Cameroon

April 17, 2018 - 08:02 -- Pierre Lutgen

                       Etude comparative de l’efficacité in vivo de l’artesunate avec l’amodiaquine et la tisane Artemisia annacultivée à Bangangté à l’Ouest du Cameroun

Chougouo Kengne R.D*., Kouamouo J*., Moyou Somo R**., Penge On’Okoko A***. *Université des Montagnes, Bangangté, Cameroun ; ** IMPM /CRM et FMSB Cameroun; *** Université de Kinshasa RDC. 

Abstract (excerpt):

Ecotoxic impacts of Ivermectin

April 13, 2018 - 14:09 -- Pierre Lutgen

This anthelminthic is extensively used as veterinary medicine to control gastro-intestinal helminthes, liver flukes and lungworms. It enters into the environment primarily through its excretion, 98% in faeces

        Halley BA, Nessel RJ, Lu AYH, Chemosphere. 1989. 18, 1543-1563.

Ivermectin may be stored for long periods in soil.

        Mougin C, Kollmann, A Galtier P. Envir Chem Lett 2003, 1, 131,-134.

The potential of anthelminthics to affect dung decomposition is well known, affecting dung beetles, dung flies and epigeic eathworms.

Prophylaxis against malaria with Azadirachta extracts and NeemAzal*

December 17, 2017 - 09:51 -- Pierre Lutgen

Azardirachta indica, Neem, is considered as the miracle tree against many diseases in many countries. One of the specific molecules of this plant is the limonoid azadirachtin, with a concentration of 0.1g/100 g in the leaves and 0.9 g/100 in the kernels.

Anthocyanins, caffeoylquinic acids, wound and ulcer healing

September 21, 2017 - 08:19 -- Pierre Lutgen

Already in 1925 burns were treated with tannins.

As it often happened in the past century the use of this natural product in the treatment of wounds was abandoned in the mid-forties due to the availability of topical antibacterial agents. It has regained interest. A clinical trial in Malawi comparing a decoction of ground tea stalks with silver sulfadiazine gave better results for bacterial growth, eschar formation.

            L Chokotho, E van Hasselt. The use of tannins in the local treatment of burn wounds-a pilot study. Malawi Med Journal, 2005, 17, 19-20

Anthocyanins and sickle cells

September 5, 2017 - 18:42 -- Pierre Lutgen

Anthocyanins are generally accepted as the largest and most important group of water-soluble pigments in nature. Research articles on anthocyanins have escalated dramatically in the last 20 years : 230 in the decade from 1982 through 1991, 753 from 1992 through 2001 and 3043 from 2002 through 2012 Anthocyanin pigments and associated flavonoids have demonstrated ability to protect against a myriad of human diseases.

        Mary Ann Lila, Anthocyanins and Human Health : an in vitro investigative Approach. J Biomed Biotechnol 2004, 5. 306-313

The underestimated role of taurine

August 14, 2017 - 06:18 -- Pierre Lutgen

                                                                           Or why cats and dogs are malariafree.

Taurine, a sulfur-containing amino acid, is the most abundant amino acid in mammals, occurring both in cells and in blood plasma. High concentrations of taurine are found in the heart, retina, bile, brain, plasma, platelets, leucocytes, whereas smaller amounts are found in liver, erythrocytes, muscles, kidney.

        Cécile Petton. La taurine: point sur ses propriétés et son utilization en 2011. Thèse de doctorat. Université dde Nantes 2011.

Ultrapurity: a fatal error in pharmacognosy

June 11, 2017 - 16:55 -- Pierre Lutgen

It is common belief and a dogma of the Western school medicine that valid results with the extracts of natural products can only be obtained if individual constituents are isolated and purified to the highest grade. This entails that most, if not all, scientific papers describing research in this field are based on monotherapies with ultrapure products.

Artemisia guérit en RDC 18 cas de malaria sévère quand les ACT ont échoué.

April 29, 2017 - 17:56 -- Pierre Lutgen

This is a translation of  the Worcester Polytechnic Institute press release 

Worcester, Mass. – April 24, 2017 – Quand les remèdes prescrits n’arrivaient plus à guérir 18 impaludés en situation désespérée, leur médecin traitant dans une clinique du Congo, en se basant sur les procedures du “compassionate use” de l’EMA, a eu recours à un mécicament non encore officiellement autorisé et consistant en comprimés de feuilles séchées de la plante Artemisia annua (désignés sous DLA).

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