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Miles Markus's blog

Hypnozoite activation demonstrated

January 6, 2020 - 01:34 -- Miles Markus

The progression to schizont formation of individual activated hypnozoites has been reported for the first time. This means that it is probably no longer appropriate to use the words "theory" and "hypothesis" when talking about hypnozoites in relation to malarial relapse. The link to the important publication concerned (by Voorberg-van der Wel et al.) is:

https://doi.org/10.1038/s42003-019-0737-3

 

Life cycle of Plasmodium

December 16, 2019 - 11:37 -- Miles Markus

Attention is drawn to a paper (by G. Franken, J. Richter, and A. Labisch) which points out, quite rightly, that it would be appropriate for more research on aspects of the life cycle of Plasmodium species that infect humans to be carried out, using modern techniques. The current "liver and blood" concept of the life cycle should not be regarded as the final "word" on the subject.

Link to the publication:

https://doi.org/10.1007/s00436-019-06564-8

Malaria and Hydrogen Peroxide

November 17, 2019 - 20:33 -- Miles Markus

In relation to some biological and epidemiological implications of the killing of Plasmodium vivax by hydrogen peroxide, discussed in a November 2019 publication (click on the first link below and, in turn, click on the "Free Download" link that comes up in a Tweet), see the comments in the MalariaWorld Newsletter by Pierre Lutgen concerning hydrogen peroxide. Find his blog via the second link provided below.

https://twitter.com/TrendsParasitol/status/1187787596317036544

Link to free P. vivax paper

October 30, 2019 - 19:32 -- Miles Markus

 

A link in the "Comment" on a new P. vivax publication listed in the MalariaWorld Newsletter this week does not appear to be "clickable". Therefore, the comment is reproduced below:

By taking the following route (if it works), this publication can be downloaded free for a limited time. Go via the link provided below. Then, in turn, click on the link in the tweet that should appear on your screen.

https://twitter.com/TrendsParasitol/status/1187787596317036544

 

Hypnozoites and relapse: theory partly wrong for the past 40 years

September 22, 2019 - 14:49 -- Miles Markus

 

Latest evidence for a non-hypnozoite (extra-hepatic), non-peripheral blood origin of Plasmodium vivax malarial recurrences:

https://doi.org/10.1016/j.pt.2019.08.009

 

Malaria: Writing Precisely

February 9, 2019 - 00:08 -- Miles Markus

 

Attention is drawn to the following three publications that are relevant to the preparation of manuscripts on malaria:

 

Markus, M.B. 2019. Plasmodium – Yet More Don’ts. Trends in Parasitology 35 (2): 101–102.

https://doi.org/10.1016/j.pt.2018.11.006

McFadden, G.I. 2019. Plasmodium – More Don’ts. Trends in Parasitology 35 (1): 4–6.

https://doi.org/10.1016/j.pt.2018.10.002

Why does vivax malaria recur?

January 24, 2019 - 23:14 -- Miles Markus

An article on vivax malarial recurrences was highlighted in the "Global Malaria News" section of last week's MalariaWorld Newsletter. Below (in the next paragraph) is a relevant explanation concerning the article (http://theconversation.com/why-does-malaria-recur-how-pieces-of-the-puzz...):

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