The Asia Pacific Malaria Elimination Network (APMEN) announced that two new partners have joined the Network – Thailand and the London School of Hygiene and Tropical Medicine. Thailand is the eleventh County Partner to join the Network. Thailand has made significant progress over the last 10 years, reducing cases by 75% from 2000 to 2009, and has developed a strategy of sub-national malaria elimination, focusing on the central and eastern portions of the country. The London School of Hygiene and Tropical Medicine (LSHTM) joins the ranks of the Network’s 21 Partner Institutions.
In recent years, there seems to have a boost in construction of large dams and irrigation schemes in sub-saharan Africa, mainly in Ethiopia. With recognition of such infrastructures to ensure economic development and allevate poverty, Ethiopia is building large dams and constructing large irrigation schemes in parts of the countries where malaria is endemic. However, such water infrastructures have been shown to intensify malaria transsmission in communities living close to water storages.
Measuring bursting strength is the standard method for evaluating mosquito net strength. However, in real life use scenarios of nets these are rarely exposed to the kind of strain they are exposed to in this test. It would correspond to, more or less, if you were to grab on to a net by the hands, uniformly and without penetrating the mesh with your fingers, and pull the net apart. Few people can do that. However, if you put the netting on a nail at one end and pull with your hand at the other, a hole will be ripped with very little effort.
Even when treated with the best anti-malaria drugs 1 in 5 children with cerebral malaria will die, and of the survivors 1 in 4 will be left with long-term learning and memory impairment. This is because the host response to the infection plays as much a role in contributing to the development of cerebral malaria as does the parasite itself. Although conventional therapies for malaria can be very effective at eliminating the parasite, they do little to modulate the host response.
The treatment of malaria has been hampered by the appearance of parasites resistant to conventional malaria drugs. Disease progression relies on the adherence of parasite-containing red blood cells to the blood vessel tissues. This condition allows the parasite to evade its clearance from the blood. Current treatments focus on killing the parasites inside of infected red blood cells but resistant strains have evolved with the ability to pump the drugs out of the erythrocytes.
Although ACTs are recommended as first line treatment for uncomplicated malaria, actual use of ACT is very limited, partly due to its high price in pharmacies and retail stores. The Affordable Medicines Facility-malaria (AMFm), a donor-funded global price subsidy, has been proposed as a strategy to increase ACT use in malaria-endemic countries. Given that donor-supported ACT subsidy schemes are costly, it is crucial to ensure that they have their intended impact.
My name is Dave Richard and I’m a new investigator based at the Centre de Recherche en Infectiologie du CHUL, Université Laval, in Quebec City, Canada.
For most part my colleagues Stella, Kabogo and I are often holed up in Malaria World, Nairobi office digging through hundreds of journals to pick out anything relevant to the “Malaria World”. Over the past weeks we have held discussions of what really happens out there, how is the war against malaria coming along? Are we loosing or winning?
We see the news that the highlands of Tanzania are under threat of increased malaria due to the warming climate.
I live in Meyer and trust me it is here.
The amount of mosquitoes has increased greatly as with malaria.
well the best layed plans of mice and men as they say.
i have had a mozzi free sleep wothout nets for three years now, was i lulled into a false security... you bet i was.
i have three children and use our prototypes throughout our homes, never missing.
after some time you forget the issue and just go through the motions.
for over fifteen years i have studied Malaria and the pest that carries it.
for me the route of intent is as follows.
kill the pest in numbers that are significant enough to make a difference.
this is best done when the pest is in the need to bite stage, this is the time when danger is there for all of us.
UN-Experts on DDT recommend stricter rules when DDT is used for malaria vector control. Their report published ahead of the 5th Conference of the Parties to the Stockholm Convention (COP-5, Geneva April 25-29, 2011), shows more and more concern about effects of DDT on human health as well as on the environment. Their report was released last week, showing that the international community might be moving towards new rules on the use of DDT.
2011 is going to be an exciting year! I am venturing out of the academic boundaries (i.e. Universities) and will make my way to entrepreneurship. Together with 2 established colleagues I'm setting up a new business/research institute in The Neterlands. Our aim is to create innovative vector control solutions, in particular for disease-endemic countries.
Late last year, I was told of a newly discovered alternative use for mosquito nets that residents from a locality in Muranga, a district in Central Kenya, have embraced. My informant called it the green house phenomena. I wanted to see the “green houses” for myself before saying much about them. Last weekend I set out to see what that was all about.
On November 12, an encounter on “DDT controversy in the face of safe and effective malaria vector control” was held in Geneva, organized by Media 21 and hosted by Biovision, icipe and the Millennium Institute with the support of the Secretariat of the Stockholm Convention. This blog summarizes the most important arguments and statements made by the panellists and the audience regarding the use of DDT in malaria vector control.
The UCSF Global Health Group’s (GHG) Health Systems Initiative supports a community of practice for National Malaria Control Program Managers and others around the private sector provision of ACTs in light of the AMFm. It recently published Large-Scale Malaria Treatment in the Private Sector: A Case Study of the Cambodian Experience, a case study aimed to inform the efforts of countries embarking on private sector malaria treatment initiatives.
Malaria is to-day a tropical disease that especially has major impact in Subsahelian Africa. The current largescale campaign against malaria focuses on better first line use of medication and prevention: (1) the combined use of an Artimisin derivative and one of several synthetic anti-malarials; and (2) the use of insecticidal bednets for transmission prevention, since the disease is transmitted between humans by female mosquitoes.
Hi Bart and Inga from very cold Canada. Lots of snow and ice so no mozzies (or malaria) here right now. :-) Cheers, Rob
My name is Ron Marchand (1951), Dutch, biologist by training and I started to work in malaria entomology in 1978 with studies on the mating behaviour and biochemical identification of sibling species of the An. gambiae Group in Tanzania. For a too short time after that I was involved in a prematurely ended research programme to develop genetic control methods for malaria vectors in the Netherlands.
UCSF Experts Outline New Strategy to Eliminate Malaria
November 5, 2010 - Global health experts at the University of California, San Francisco (UCSF) have outlined a new strategy and action plan to help countries eliminate malaria and bring the world closer to global eradication of the deadly disease.
Kija R.N. Ng’habi
This thesis specifically investigated (i) the effect of larval density and nutrition on the mating competitiveness of adult male Anopheles gambiae s.s mosquitoes (ii) compared the physiological fitness of male Anopheles gambiae mosquitoes between laboratory and field populations, (iii) the potential for establishing a self-replicating Anopheles arabiensis population in an enclosed semi-natural environment and observing its genetic variation over time, (iv) the development of a PCR-based method for assessing male mating success among inseminated female An. gambiae and (v) the population genetic structure of An. gambiae s. l. along the Kilombero valley (southern Tanzania).
After a long stint, I finally managed to go home for a visit last weekend. Its been raining in Nairobi over the last few days so there are puddles of water here and there and my home is no exception. You already know am going to talk about mosquitoes and malaria well yes I am.
Hi malaria world comunity
how do you treat a chlid 02 month age with malaria vivax?
primaquin is posible? or wait for treatment with primaquin
We have collated and mapped reports of the dhps K540E mutation in Africa. The mutation is a marker of resistance to SP (Fansidar) and has a remarkable geographical distribution.
Check the interactive map http://www.drugresistancemaps.org/maps/dhps540/ to see the distribution and check that your study has been included.
Inbarani Naidoo and Cally Roper
Professor Diwan S Rawat
Department of Chemistry, University of Delhi, Delhi-110007, INDIA
Summary of malaria research
Human has been successful in the eradication of species as the moa or the dront. The war against mosquitoes started in the beginning of the 20th century and more effort has been put in it than in any other eradication project. Still it has not been very effective. Sardinia was practically covered with DDT after WWII, but it is not unusual to stumble on Anopheles labranchiae there again.
This season I have together with my husband been monitoring bloodsucking insects at the reindeer research station in Kaamanen, Lapland Finland (69˚ N lat.). The station is about 150 km from Barents Sea and the snow smelts in late May. The ground is frozen from October/November until May/June and the depth of the frost is 80 cm. The staff at the station is really friendly and helpful.
Current malaria control operations rely heavily on insecticide treated nets (ITNs) and indoor residual spraying (IRS), both of which are insecticide-based and target only mosquitoes that feed or rest inside houses. Although these methods are extremely powerful and have saved many lives, the protection that they confer is insufficient to eliminate malaria in the most endemic regions of Africa.
It has long been postulated that complementary methods to build upon these gains could include, among other options, novel technologies derived from synthetic human odors.
The Asia Pacific Malaria Elimination Network (APMEN) today, 25th June, is launching the APMEN Research Grant Program, which aims to assist in the development of new tools and measures to eliminate malaria in the Asia Pacific Region. The Network is composed of 10 countries working to eliminate malaria (Bhutan, China, Democratic People’s Republic of Korea, Indonesia, Malaysia, Philippines, Republic of Korea, the Solomon Islands, Sri Lanka, and Vanuatu) along with partner and research institutions in the region, including WHO.