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Hypnozoite activation demonstrated

January 6, 2020 - 01:34 -- Miles Markus

The progression to schizont formation of individual activated hypnozoites has been reported for the first time. This means that it is probably no longer appropriate to use the words "theory" and "hypothesis" when talking about hypnozoites in relation to malarial relapse. The link to the important publication concerned (by Voorberg-van der Wel et al.) is:

https://doi.org/10.1038/s42003-019-0737-3

 

Life cycle of Plasmodium

December 16, 2019 - 11:37 -- Miles Markus

Attention is drawn to a paper (by G. Franken, J. Richter, and A. Labisch) which points out, quite rightly, that it would be appropriate for more research on aspects of the life cycle of Plasmodium species that infect humans to be carried out, using modern techniques. The current "liver and blood" concept of the life cycle should not be regarded as the final "word" on the subject.

Link to the publication:

https://doi.org/10.1007/s00436-019-06564-8

Revolting: Artemisia plantations destroyed by police in Cameroon

November 24, 2019 - 19:46 -- Irene Teis

 

Since 15 years, the Université des Montagnes is at the forefront of research and clinical trials demonstrating the astonishing efficacy of Artemisia plants against malaria. The local population of Cameroon has become enthusiastic about this cheap and efficient weapon against the malaria scourge. Despite the billions invested in bednets and drugs by Bill Gates, Bigpharma, WHO and France the disease has seen a dramatic increase in Cameroon over the recent years. This was recognized by the French ambassador at a meeting at the Hilton-Yaoundé on April 17th 2019.

Malaria and Hydrogen Peroxide

November 17, 2019 - 20:33 -- Miles Markus

In relation to some biological and epidemiological implications of the killing of Plasmodium vivax by hydrogen peroxide, discussed in a November 2019 publication (click on the first link below and, in turn, click on the "Free Download" link that comes up in a Tweet), see the comments in the MalariaWorld Newsletter by Pierre Lutgen concerning hydrogen peroxide. Find his blog via the second link provided below.

https://twitter.com/TrendsParasitol/status/1187787596317036544

Link to free P. vivax paper

October 30, 2019 - 19:32 -- Miles Markus

 

A link in the "Comment" on a new P. vivax publication listed in the MalariaWorld Newsletter this week does not appear to be "clickable". Therefore, the comment is reproduced below:

By taking the following route (if it works), this publication can be downloaded free for a limited time. Go via the link provided below. Then, in turn, click on the link in the tweet that should appear on your screen.

https://twitter.com/TrendsParasitol/status/1187787596317036544

 

Installing window screens for at-need homes: Moving from the classroom to the office in efforts to eliminate malaria

June 4, 2019 - 01:01 -- Beverly Anaele

Oftentimes when referring to global health crises around the globe, the circulating mindset whether in media or conversation is that if burdened communities knew how to protect themselves better, they would not suffer as extensively as they do. My time in Kigali, Rwanda taught me differently.

Malaria Vaccine: Our Best Shot?

May 9, 2019 - 19:17 -- Beverly Anaele

By now, the world is gasping together at the roll-out of a vaccine to prevent malaria among children. The origin of this shock, however, is what varies. For some, the amazement comes from the prospect of a novel preventative tool that sounds like it will be a leading soldier in the fight against malaria. Still, others who know of its low protection rate (about 39%) gasp in shock that this tool is being used at all.

IRS quantification in field any easy method available??

March 28, 2019 - 03:41 -- Praveen K S

Dear Experts across the world, 

I looking out for a way to quantify the IRS in field itself without the filter papers being sent to the central laboratories for testing. Does anyone have got an idea how to do this? The information will be greatly useful for me to try it in India. 

Regards, 

Praveen

Malaria: Writing Precisely

February 9, 2019 - 00:08 -- Miles Markus

 

Attention is drawn to the following three publications that are relevant to the preparation of manuscripts on malaria:

 

Markus, M.B. 2019. Plasmodium – Yet More Don’ts. Trends in Parasitology 35 (2): 101–102.

https://doi.org/10.1016/j.pt.2018.11.006

McFadden, G.I. 2019. Plasmodium – More Don’ts. Trends in Parasitology 35 (1): 4–6.

https://doi.org/10.1016/j.pt.2018.10.002

Let’s ‘cut to the chase’ on malaria elimination in the Greater Mekong Sub-region.

February 2, 2019 - 13:24 -- Sean Hewitt

The Greater Mekong Sub-region has made remarkable progress towards eliminating malaria in recent years, but efforts are now faltering in some areas. The development of tools to control forest-based transmission is taking too long and efforts to control malaria amongst high-risk mobile people are failing. If countries are to meet their elimination targets and prevent the spread of multi-drug resistant falciparum malaria, urgent and radical changes will be required.

Why does vivax malaria recur?

January 24, 2019 - 23:14 -- Miles Markus

An article on vivax malarial recurrences was highlighted in the "Global Malaria News" section of last week's MalariaWorld Newsletter. Below (in the next paragraph) is a relevant explanation concerning the article (http://theconversation.com/why-does-malaria-recur-how-pieces-of-the-puzz...):

Mosquito experts or sorcerers: Bill Gates and Erik Orsenna

December 4, 2018 - 07:30 -- Irene Teis

Genetically engineered mosquitoes are due to be released in Burkina Faso, Mali and Uganda by the Target Malaria research consortium. Target Malaria is a consortium of research institutes that receives core funding from the Bill & Melinda Gates Foundation, Silicon Valley companies and the Pentagon. In Burkina researchers recently secured government approval to release up to 10,000 sterile male Anopheles gambiae mosquitoes.

Significance of time to clinical recurrence in vivax malaria

October 12, 2018 - 10:55 -- Miles Markus

The amount of time that passes between a symptomatic vivax malarial episode and a subsequent recurrence has in the past often been regarded as an indication as to whether the recurrence is a relapse (hypnozoite origin) or a recrudescence (merozoite origin). It should be noted that in the light of new knowledge and understanding, the time factor is not a valid criterion. (Link to first paper). (Link to second paper).

Dynamic Landscape Of Indian Mosquito Repellent Market Outlook: Ken Research

October 3, 2018 - 08:35 -- Richa Sharma

The government of India is playing efficient role in developing the nation’s framework at any instance. Moreover, in the healthcare industry it makes so many innovations for minimizing the negative effective of disease. Furthermore, malaria is the main public health problem in the numerous states of India which majorly includes North East segment. The government of India is projecting so many programs and projects which are very much useful for the general public as in these programs government spread awareness related to the malaria and other related viruses.

TANZANIA

September 14, 2018 - 20:28 -- malcolm doherty

i have lived here in Tanzania for almost 18 years now. i was in Kenya prior to that working with pyrethrum as an effective repellent and killer.since coming to Tanzania i have tried and tested so many formulas on the market as well as created some of my own. at one stage i was working with the head of the Malaria campaign here Alex Mwita based at the world health organisation offices in Dar es Salaam. when i came here early 2000 i found breeding grounds were the biggest issue as everywhere there was standing water as well as rivers with steady corners allowing breeding.

Malaria elimination problem

September 13, 2018 - 23:36 -- Miles Markus

We talk about asymptomatic, submicroscopic plasmodial infections as potentially being a threat to the elimination of malaria. This is, of course, partly because such infections are not normally treated; especially not in rural endemic areas where laboratory facilities are limited. An aggravation of the situation is when parasitaemias are so low that they cannot be detected by molecular diagnosis (where available) either. But obstacles to elimination are probably even greater than has been realized.

Blame the Pathogen, Not the Needle

August 21, 2018 - 07:30 -- Beverly Anaele

Yesterday, August 20th, was World Mosquito Day, which may seemingly sound like a day to honor the mosquito. Yet, more often than not, the narrative that permeates posts and notifications for this awareness day details of how bothersome the mosquito is, how undesirable, and how evil. Communicators may knowingly or unknowingly paint a portrait of a mosquito who intentionally picks up pathogens involved with spreading malaria, Zika, West Nile, or another, then buzzes deviously around spreading them to any and all unsuspecting humans like pollinating honey bees.

Plasmodium vivax comment links

July 20, 2018 - 22:50 -- Miles Markus

The two links below did not come up in the original "Comment" on a paper but should do so in this "Blog" version, which appears in full below. It was speculated in detail for the first time in two recent publications (particularly the second one) that in addition to a hypnozoite origin of relapse-like vivax recurrences, parasites in bone marrow might be a source. (Link to first paper). (Link to second paper).

Views and Impressions from the 1st World Malaria Congress - Part 1

July 11, 2018 - 06:15 -- Ricardo Ataide

As the first of its kind, the World Malaria Congress was a stunning success. The Congress organizing committee should be very proud. Grant you, it was not perfect, but first times seldom are. There was a certain rush in getting things done, an eagerness to bring to bed groups that should have had a coffee and a walk in the park beforehand in order to get to know each other's language and idiosyncrasies, likes and dislikes. But the reality of it is that things got done. People engaged with each other and held productive discussions on sensitive topics.

Open access Cochrane Reviews on malaria interventions

June 29, 2018 - 09:43 -- Dee Walshe

Hello,

The Cochrane Infectious Diseases Group (CIDG) has published several systematic reviews of malaria interventions which may be of interest to Malaria World members. Each of the reviews are open access and are accessible via the Cochrane Library:

http://www.cochranelibrary.com/review-group/Infectious%20Diseases%20Group/

Best wishes,

Dee Walshe

Managing Editor, CIDG

The hypnozoite concept of malarial relapse is outdated

May 29, 2018 - 14:47 -- Miles Markus

UPDATE COMMENTARY: Acquisition of novel insights has been taking place (reflected especially in 2018 reports) in relation to where plasmodial parasites go in the mammalian body. This new understanding has led to the hypnozoite hypothesis of relapse in malaria becoming partly out of date insofar as it is now a theory that is (in the way it has been applied since 1980) too restrictive. To elucidate:

Patterns of insecticide resistance in African mosquito malaria vectors

May 24, 2018 - 12:09 -- Penny Hancock

https://doi.org/10.1073/pnas.1801826115

In this study, we analysed observations of resistance levels in some of the most important malaria vector species sampled from 1183 locations spanning 38 African countries. If mosquitoes show cross-resistance to multiple insecticide types, then the number of insecticides that remain effective is limited. Therefore, our research looked for evidence of common patterns of resistance amongst the different types of insecticides that are most important in mosquito control programs.

Relapse in Malaria: P.G. Shute’s “X Body”

May 15, 2018 - 22:20 -- Miles Markus

Was P.G. Shute’s “X Body” the same plasmodial stage that is now called a “hypnozoite”? The short answer is “No”. The malariologist who has just put this question to me has suggested that the whole reply (see below) be made available in the MalariaWorld Newsletter, considering the current topicality of the enigmatic hypnozoite; particularly in regard to the concept of malaria eradication.

Bone Marrow and Hypnozoite-Independent Plasmodium vivax Malarial Recurrences

May 11, 2018 - 20:19 -- Miles Markus

As shown by the record of historical events listed in Table 1 in a recent review of biological concepts in recurrent vivax malaria, the question of a hypnozoite-independent, non-circulating origin(s) of recurrences was first raised approximately 7 years ago. (Link to the paper and Table 1 [click here]). More specifically, parasites in bone marrow as a possible contributing source are discussed in this 2018 article, the matter having initially been debated in a 2017 publication cited therein.

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