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Where was malaria control attempted between 1904 - 1922?

Apart from at the Panama Canal, does anyone know where malaria control was attempted before 1922?

Views and Impressions from the 1st World Malaria Congress - Part 1

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As the first of its kind, the World Malaria Congress was a stunning success. The Congress organizing committee should be very proud. Grant you, it was not perfect, but first times seldom are. There was a certain rush in getting things done, an eagerness to bring to bed groups that should have had a coffee and a walk in the park beforehand in order to get to know each other's language and idiosyncrasies, likes and dislikes. But the reality of it is that things got done. People engaged with each other and held productive discussions on sensitive topics.

Open access Cochrane Reviews on malaria interventions

Hello,

The Cochrane Infectious Diseases Group (CIDG) has published several systematic reviews of malaria interventions which may be of interest to Malaria World members. Each of the reviews are open access and are accessible via the Cochrane Library:

http://www.cochranelibrary.com/review-group/Infectious%20Diseases%20Group/

Best wishes,

Dee Walshe

Managing Editor, CIDG

The hypnozoite concept of malarial relapse is outdated

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artemisinin; bone marrow; chloroquine; control; dendritic cell; drug failure; elimination; eradication; hypnozoite; lymphatic system; malaria; merophore; Plasmodium cynomolgi; Plasmodium vivax; primaquine; recrudescence; recurrence; relapse; skin; spleen

UPDATE COMMENTARY: Acquisition of novel insights has been taking place (reflected especially in 2018 reports) in relation to where plasmodial parasites go in the mammalian body. This new understanding has led to the hypnozoite hypothesis of relapse in malaria becoming partly out of date insofar as it is now a theory that is (in the way it has been applied since 1980) too restrictive. To elucidate:

Patterns of insecticide resistance in African mosquito malaria vectors

https://doi.org/10.1073/pnas.1801826115

In this study, we analysed observations of resistance levels in some of the most important malaria vector species sampled from 1183 locations spanning 38 African countries. If mosquitoes show cross-resistance to multiple insecticide types, then the number of insecticides that remain effective is limited. Therefore, our research looked for evidence of common patterns of resistance amongst the different types of insecticides that are most important in mosquito control programs.

Relapse in Malaria: P.G. Shute’s “X Body”

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elimination; eradication; history; hypnozoite; malaria; Plasmodium vivax; relapse; Shute; X-body

Was P.G. Shute’s “X Body” the same plasmodial stage that is now called a “hypnozoite”? The short answer is “No”. The malariologist who has just put this question to me has suggested that the whole reply (see below) be made available in the MalariaWorld Newsletter, considering the current topicality of the enigmatic hypnozoite; particularly in regard to the concept of malaria eradication.

Bone Marrow and Hypnozoite-Independent Plasmodium vivax Malarial Recurrences

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bone marrow; control; elimination; eradication; history; hypnozoite; malaria; Plasmodium cynomolgi; Plasmodium vivax; primaquine; recrudescence; recurrence; relapse

As shown by the record of historical events listed in Table 1 in a recent review of biological concepts in recurrent vivax malaria, the question of a hypnozoite-independent, non-circulating origin(s) of recurrences was first raised approximately 7 years ago. (Link to the paper and Table 1 [click here]). More specifically, parasites in bone marrow as a possible contributing source are discussed in this 2018 article, the matter having initially been debated in a 2017 publication cited therein.

The abstract book of the MIM2018 conference is now available

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